Abstract
Metabolic and cardiovascular diseases are increasing worldwide due to the rise in the obesity epidemic. The metabolic consequences of obesity vary by distribution of adipose tissue. Visceral and ectopic adipose accumulation are associated with adverse cardiometabolic consequences, while gluteal-femoral adipose accumulation are negatively associated with these adverse complications and subcutaneous abdominal adipose accumulation is more neutral in its associations. Gender, race and ethnic differences in adipose tissue distribution have been described and could account for the observed differences in risk for cardiometabolic disease. The mechanisms behind the differential impact of adipose tissue on cardiometabolic risk have started to be unraveled and include differences in adipocyte biology, inflammatory profile, connection to systemic circulation and most importantly the inability of the subcutaneous adipose tissue to expand in response to positive energy balance.
Author Statement
Research funding: Authors state no funding involved.
Conflict of interest: Authors state no conflict of interest.
Informed consent: Informed consent is not applicable.
Ethical approval: The conducted research is not related to either human or animals use.
References
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©2018 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Review Articles
- Differential effect of subcutaneous abdominal and visceral adipose tissue on cardiometabolic risk
- Visceral adipose tissue in patients with severe mental illness
- Mini Review Articles
- Subcutaneous adipose tissue biology in metabolic syndrome
- The origin and purpose of layers of subcutaneous adipose tissue in pigs and man
- Original Article
- Lipedema: friend and foe
Artikel in diesem Heft
- Review Articles
- Differential effect of subcutaneous abdominal and visceral adipose tissue on cardiometabolic risk
- Visceral adipose tissue in patients with severe mental illness
- Mini Review Articles
- Subcutaneous adipose tissue biology in metabolic syndrome
- The origin and purpose of layers of subcutaneous adipose tissue in pigs and man
- Original Article
- Lipedema: friend and foe