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Adipose tissue inflammation and cancer cachexia: the role of steroid hormones

  • Marilia C.L. Seelaender EMAIL logo und Miguel Luiz Batista
Veröffentlicht/Copyright: 19. Oktober 2013
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Abstract

Adipose tissue inflammation plays a role in the etiology of many chronic diseases, and has been the focus of much attention in the context of obesity and metabolic syndrome. Similarly, during cancer cachexia, a syndrome that markedly increases cancer-associated morbidity and mortality, local adipose inflammation is reported in animal models and in patients, potentially contributing to the chronic systemic inflammation that constitutes the hallmark of this condition. We discuss, on the basis of information generated by obesity-related studies, the possible relation between adipose tissue inflammation and compromised steroid hormone secretion and action in cachexia.


Corresponding author: Marilia C.L. Seelaender, Cancer Metabolism Research Group, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo 05508-900, Brazil, Phone/Fax: +55 011 3091 7402, E-mail:

Acknowledgment

The studies of the group cited in the text were carried out with funding obtained from FAPESP (Fundação de Amparo à Pesquisa do Estado de São Paulo, 08/54091-9; 12/50079-0).

References

1. Calabro P, Golia E, Maddaloni V, Malvezzi M, Casillo B, Marotta C, Calabro R, Golino P. Adipose tissue-mediated inflammation: the missing link between obesity and cardiovascular disease? Intern Emerg Med 2009;4:25–34.10.1007/s11739-008-0207-2Suche in Google Scholar PubMed

2. Fantuzzi G. Adiponectin and inflammation: consensus and controversy. J Allergy Clin Immunol 2008;121:326–30.10.1016/j.jaci.2007.10.018Suche in Google Scholar PubMed

3. Hotamisligil GS. Inflammation and metabolic disorders. Nature 2006;444:860–7.10.1038/nature05485Suche in Google Scholar PubMed

4. Lafontan M. Historical perspectives in fat cell biology: the fat cell as a model for the investigation of hormonal and metabolic pathways. Am J Physiol Cell Physiol 2012;302: C327–9.10.1152/ajpcell.00168.2011Suche in Google Scholar PubMed

5. Cinti S. The adipose organ at a glance. Dis Model Mech 2012;5:588–94.10.1242/dmm.009662Suche in Google Scholar PubMed PubMed Central

6. Cinti S. Reversible physiological transdifferentiation in the adipose organ. Proc Nutr Soc 2009;68:340–9.10.1017/S0029665109990140Suche in Google Scholar PubMed

7. Cinti S. Between brown and white: novel aspects of adipocyte differentiation. Ann Med 2011;43:104–15.10.3109/07853890.2010.535557Suche in Google Scholar PubMed

8. Cinti S, Cigolini M, Gazzanelli G, Bosello O. An ultrastructural study of adipocyte precursors from epididymal fat pads of adult rats in culture. J Submicrosc Cytol 1985;17:631–6.Suche in Google Scholar

9. Cinti S. The adipose organ. Prostaglandins Leukot Essent Fatty Acids 2005;73:9–15.10.1016/j.plefa.2005.04.010Suche in Google Scholar PubMed

10. Beranger GE, Karbiener M, Barquissau V, Pisani DF, Scheideler M, Langin D, Amri EZ. In vitro brown and “brite”/“beige” adipogenesis: human cellular models and molecular aspects. Biochim Biophys Acta 2013;1831:905–14.10.1016/j.bbalip.2012.11.001Suche in Google Scholar PubMed

11. Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-α: direct role in obesity-linked insulin resistance. Science 1993;259:87–91.10.1126/science.7678183Suche in Google Scholar PubMed

12. Ouchi N, Parker JL, Lugus JJ, Walsh K. Adipokines in inflammation and metabolic disease. Nat Rev Immunol 2011;11:85–97.10.1038/nri2921Suche in Google Scholar PubMed PubMed Central

13. Berg AH, Scherer PE. Adipose tissue, inflammation, and cardiovascular disease. Circ Res 2005;96:939–49.10.1161/01.RES.0000163635.62927.34Suche in Google Scholar PubMed

14. Divoux A, Tordjman J, Lacasa D, Veyrie N, Hugol D, Aissat A, Basdevant A, Guerre-Millo M, Poitou C, Zucker JD, Bedossa P, Clement K. Fibrosis in human adipose tissue: composition, distribution, and link with lipid metabolism and fat mass loss. Diabetes 2010;59:2817–25.10.2337/db10-0585Suche in Google Scholar PubMed PubMed Central

15. Tchernof A, Despres JP. Pathophysiology of human visceral obesity: an update. Physiol Rev 2013;93:359–404.10.1152/physrev.00033.2011Suche in Google Scholar PubMed

16. Sun K, Kusminski CM, Scherer PE. Adipose tissue remodeling and obesity. J Clin Invest 2011;121:2094–101.10.1172/JCI45887Suche in Google Scholar PubMed PubMed Central

17. Almind K, Manieri M, Sivitz WI, Cinti S, Kahn CR. Ectopic brown adipose tissue in muscle provides a mechanism for differences in risk of metabolic syndrome in mice. Proc Natl Acad Sci USA 2007;104:2366–71.10.1073/pnas.0610416104Suche in Google Scholar PubMed PubMed Central

18. Suganami T, Tanaka M, Ogawa Y. Adipose tissue inflammation and ectopic lipid accumulation. Endocr J 2012;59:849–57.10.1507/endocrj.EJ12-0271Suche in Google Scholar

19. Clement K, Viguerie N, Poitou C, Carette C, Pelloux V, Curat CA, Sicard A, Rome S, Benis A, Zucker JD, Vidal H, Laville M, Barsh GS, Basdevant A, Stich V, Cancello R, Langin D. Weight loss regulates inflammation-related genes in white adipose tissue of obese subjects. FASEB J 2004;18:1657–69.10.1096/fj.04-2204comSuche in Google Scholar PubMed

20. Patel PS, Buras ED, Balasubramanyam A. The role of the immune system in obesity and insulin resistance. J Obes 2013;2013:616193.10.1155/2013/616193Suche in Google Scholar PubMed PubMed Central

21. Medzhitov R. Origin and physiological roles of inflammation. Nature 2008;454:428–35.10.1038/nature07201Suche in Google Scholar PubMed

22. Batista ML Jr, Neves RX, Peres SB, Yamashita AS, Shida CS, Farmer SR, Seelaender M. Heterogeneous time-dependent response of adipose tissue during the development of cancer cachexia. J Endocrinol 2012;215:363–73.10.1530/JOE-12-0307Suche in Google Scholar PubMed

23. Ito A, Suganami T, Yamauchi A, Degawa-Yamauchi M, Tanaka M, Kouyama R, Kobayashi Y, Nitta N, Yasuda K, Hirata Y, Kuziel WA, Takeya M, Kanegasaki S, Kamei Y, Ogawa Y. Role of CC chemokine receptor 2 in bone marrow cells in the recruitment of macrophages into obese adipose tissue. J Biol Chem 2008;283:35715–23.10.1074/jbc.M804220200Suche in Google Scholar PubMed

24. Johnson AR, Milner JJ, Makowski L. The inflammation highway: metabolism accelerates inflammatory traffic in obesity. Immunol Rev 2012;249:218–38.10.1111/j.1600-065X.2012.01151.xSuche in Google Scholar PubMed PubMed Central

25. Cinti S, Mitchell G, Barbatelli G, Murano I, Ceresi E, Faloia E, Wang S, Fortier M, Greenberg AS, Obin MS. Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J Lipid Res 2005;46:2347–55.10.1194/jlr.M500294-JLR200Suche in Google Scholar PubMed

26. Tchkonia T, Thomou T, Zhu Y, Karagiannides I, Pothoulakis C, Jensen MD, Kirkland JL. Mechanisms and metabolic implications of regional differences among fat depots. Cell Metab 2013;17:644–56.10.1016/j.cmet.2013.03.008Suche in Google Scholar PubMed PubMed Central

27. Batista ML Jr, Peres SB, McDonald ME, Alcantara PS, Olivan M, Otoch JP, Farmer SR, Seelaender M. Adipose tissue inflammation and cancer cachexia: possible role of nuclear transcription factors. Cytokine 2012;57:9–16.10.1016/j.cyto.2011.10.008Suche in Google Scholar PubMed

28. Serhan CN, Savill J. Resolution of inflammation: the beginning programs the end. Nat Immunol 2005;6:1191–7.10.1038/ni1276Suche in Google Scholar PubMed

29. Nishimura S. [In vivo imaging reveals adipose tissue inflammation in obesity and multi-cellular processes of developing thrombus]. Yakugaku Zasshi 2012;132:425–31.10.1248/yakushi.132.425Suche in Google Scholar PubMed

30. Arner P, Spalding KL. Fat cell turnover in humans. Biochem Biophys Res Commun 2010;396:101–4.10.1016/j.bbrc.2010.02.165Suche in Google Scholar PubMed

31. Suganami T, Ogawa Y. Adipose tissue macrophages: their role in adipose tissue remodeling. J Leukoc Biol 2010;88:33–9.10.1189/jlb.0210072Suche in Google Scholar PubMed

32. Olefsky JM, Glass CK. Macrophages, inflammation, and insulin resistance. Annu Rev Physiol 2010;72:219–46.10.1146/annurev-physiol-021909-135846Suche in Google Scholar

33. Ottaviani E, Malagoli D, Franceschi C. The evolution of the adipose tissue: a neglected enigma. Gen Comp Endocrinol 2011;174:1–4.10.1016/j.ygcen.2011.06.018Suche in Google Scholar

34. Khan T, Muise ES, Iyengar P, Wang ZV, Chandalia M, Abate N, Zhang BB, Bonaldo P, Chua S, Scherer PE. Metabolic dysregulation and adipose tissue fibrosis: role of collagen VI. Mol Cell Biol 2009;29:1575–91.10.1128/MCB.01300-08Suche in Google Scholar

35. Mutch DM, Tordjman J, Pelloux V, Hanczar B, Henegar C, Poitou C, Veyrie N, Zucker JD, Clement K. Needle and surgical biopsy techniques differentially affect adipose tissue gene expression profiles. Am J Clin Nutr 2009;89:51–7.10.3945/ajcn.2008.26802Suche in Google Scholar

36. Khan S, Tisdale MJ. Catabolism of adipose tissue by a tumour-produced lipid-mobilising factor. Int J Cancer 1999;80:444–7.10.1002/(SICI)1097-0215(19990129)80:3<444::AID-IJC18>3.0.CO;2-USuche in Google Scholar

37. Strissel KJ, Stancheva Z, Miyoshi H, Perfield JW 2nd, DeFuria J, Jick Z, Greenberg AS, Obin MS. Adipocyte death, adipose tissue remodeling, and obesity complications. Diabetes 2007;56:2910–8.10.2337/db07-0767Suche in Google Scholar

38. Duval C, Thissen U, Keshtkar S, Accart B, Stienstra R, Boekschoten MV, Roskams T, Kersten S, Muller M. Adipose tissue dysfunction signals progression of hepatic steatosis towards nonalcoholic steatohepatitis in c57bl/6 mice. Diabetes 2010;59:3181–91.10.2337/db10-0224Suche in Google Scholar

39. Alemany M. Relationship between energy dense diets and white adipose tissue inflammation in metabolic syndrome. Nutr Res 2013;33:1–11.10.1016/j.nutres.2012.11.013Suche in Google Scholar

40. Man XY, Li W, Chen JQ, Zhou J, Landeck L, Zhang KH, Mu Z, Li CM, Cai SQ, Zheng M. Impaired nuclear translocation of glucocorticoid receptors: novel findings from psoriatic epidermal keratinocytes. Cell Mol Life Sci 2013;70:2205–20.10.1007/s00018-012-1255-3Suche in Google Scholar

41. Gavin KM, Cooper EE, Raymer DK, Hickner RC. Estradiol effects on subcutaneous adipose tissue lipolysis in premenopausal women are adipose tissue depot specific and treatment dependent. Am J Physiol Endocrinol Metab 2013;304:E1167–74.10.1152/ajpendo.00023.2013Suche in Google Scholar

42. Waanders F, de Vries LV, van Goor H, Hillebrands JL, Laverman GD, Bakker SJ, Navis G. Aldosterone, from (patho)physiology to treatment in cardiovascular and renal damage. Curr Vasc Pharmacol 2011;9:594–605.10.2174/157016111796642689Suche in Google Scholar

43. Marik PE. Glucocorticoids in sepsis: dissecting facts from fiction. Crit Care 2011;15:158.10.1186/cc10101Suche in Google Scholar

44. Briones AM, Nguyen Dinh Cat A, Callera GE, Yogi A, Burger D, He Y, Correa JW, Gagnon AM, Gomez-Sanchez CE, Gomez-Sanchez EP, Sorisky A, Ooi TC, Ruzicka M, Burns KD, Touyz RM. Adipocytes produce aldosterone through calcineurin-dependent signaling pathways: implications in diabetes mellitus-associated obesity and vascular dysfunction. Hypertension 2012;59:1069–78.10.1161/HYPERTENSIONAHA.111.190223Suche in Google Scholar

45. Carlson MJ, Thiel KW, Yang S, Leslie KK. Catch it before it kills: progesterone, obesity, and the prevention of endometrial cancer. Discov Med 2012;14:215–22.Suche in Google Scholar

46. Nguyen Dinh Cat A, Jaisser F. Extrarenal effects of aldosterone. Curr Opin Nephrol Hypertens 2012;21:147–56.10.1097/MNH.0b013e32834fb25bSuche in Google Scholar

47. Yonezawa R, Wada T, Matsumoto N, Morita M, Sawakawa K, Ishii Y, Sasahara M, Tsuneki H, Saito S, Sasaoka T. Central versus peripheral impact of estradiol on the impaired glucose metabolism in ovariectomized mice on a high-fat diet. Am J Physiol Endocrinol Metab 2012;303:E445–56.10.1152/ajpendo.00638.2011Suche in Google Scholar

48. Fearon KC, Moses AG. Cancer cachexia. Int J Cardiol 2002;85:73–81.10.1016/S0167-5273(02)00235-8Suche in Google Scholar

49. Argiles JM, Alvarez B, Lopez-Soriano FJ. The metabolic basis of cancer cachexia. Med Res Rev 1997;17:477–98.10.1002/(SICI)1098-1128(199709)17:5<477::AID-MED3>3.0.CO;2-RSuche in Google Scholar

50. Kumar NB, Kazi A, Smith T, Crocker T, Yu D, Reich RR, Reddy K, Hastings S, Exterman M, Balducci L, Dalton K, Bepler G. Cancer cachexia: traditional therapies and novel molecular mechanism-based approaches to treatment. Curr Treat Options Oncol 2010;11:107–17.10.1007/s11864-010-0127-zSuche in Google Scholar

51. Tisdale MJ. Cancer cachexia. Curr Opin Gastroenterol 2010;26:146–51.10.1097/MOG.0b013e3283347e77Suche in Google Scholar

52. Strasser F, Bruera ED. Update on anorexia and cachexia. Hematol Oncol Clin North Am 2002;16:589–617.10.1016/S0889-8588(02)00011-4Suche in Google Scholar

53. Evans WJ, Morley JE, Argiles J, Bales C, Baracos V, Guttridge D, Jatoi A, Kalantar-Zadeh K, Lochs H, Mantovani G, Marks D, Mitch WE, Muscaritoli M, Najand A, Ponikowski P, Rossi Fanelli F, Schambelan M, Schols A, Schuster M, Thomas D, Wolfe R, Anker SD. Cachexia: a new definition. Clin Nutr 2008;27:793–9.10.1016/j.clnu.2008.06.013Suche in Google Scholar

54. Springer J, Filippatos G, Akashi YJ, Anker SD. Prognosis and therapy approaches of cardiac cachexia. Curr Opin Cardiol 2006;21:229–33.10.1097/01.hco.0000221585.94490.09Suche in Google Scholar

55. Tan BH, Fearon KC. Cachexia: prevalence and impact in medicine. Curr Opin Clin Nutr Metab Care 2008;11:400–7.10.1097/MCO.0b013e328300ecc1Suche in Google Scholar

56. Fearon KC. The 2011 ESPEN Arvid Wretlind lecture: cancer cachexia: the potential impact of translational research on patient-focused outcomes. Clin Nutr 2012;31:577–82.10.1016/j.clnu.2012.06.012Suche in Google Scholar

57. Argiles JM, Busquets S, Lopez-Soriano FJ. Anti-inflammatory therapies in cancer cachexia. Eur J Pharmacol 2011;668(Suppl 1):S81–6.10.1016/j.ejphar.2011.07.007Suche in Google Scholar

58. Wigmore SJ, Ross JA, Falconer JS, Plester CE, Tisdale MJ, Carter DC, Fearon KC. The effect of polyunsaturated fatty acids on the progress of cachexia in patients with pancreatic cancer. Nutrition 1996;12:S27–30.10.1016/0899-9007(96)90014-3Suche in Google Scholar

59. Argiles JM, Busquets S, Toledo M, Lopez-Soriano FJ. The role of cytokines in cancer cachexia. Curr Opin Support Palliat Care 2009;3:263–8.10.1097/SPC.0b013e3283311d09Suche in Google Scholar PubMed

60. Batista ML Jr, Olivan M, Alcantara PS, Sandoval R, Peres SB, Neves RX, Silverio R, Maximiano LF, Otoch JP, Seelaender M. Adipose tissue-derived factors as potential biomarkers in cachectic cancer patients. Cytokine 2013;61:532–9.10.1016/j.cyto.2012.10.023Suche in Google Scholar PubMed

61. Donatto FF, Neves RX, Rosa FO, Camargo RG, Ribeiro H, Matos-Neto EM, Seelaender M. Resistance exercise modulates lipid plasma profile and cytokine content in the adipose tissue of tumour-bearing rats. Cytokine 2013;61:426–32.10.1016/j.cyto.2012.10.021Suche in Google Scholar PubMed

62. Lira FS, Yamashita AS, Rosa JC, Koyama CH, Caperuto EC, Batista ML Jr., Seelaender MC. Exercise training decreases adipose tissue inflammation in cachectic rats. Horm Metab Res 2012;44:91–8.10.1055/s-0031-1299694Suche in Google Scholar PubMed

63. Flammer JR, Rogatsky I. Minireview: glucocorticoids in autoimmunity: unexpected targets and mechanisms. Mol Endocrinol 2011;25:1075–86.10.1210/me.2011-0068Suche in Google Scholar PubMed PubMed Central

64. Del Fabbro E, Hui D, Nooruddin ZI, Dalal S, Dev R, Freer G, Roberts L, Palmer JL, Bruera E. Associations among hypogonadism, C-reactive protein, symptom burden, and survival in male cancer patients with cachexia: a preliminary report. J Pain Symptom Manage 2010;39:1016–24.10.1016/j.jpainsymman.2009.09.021Suche in Google Scholar PubMed

65. Gupta SC, Kim JH, Kannappan R, Reuter S, Dougherty PM, Aggarwal BB. Role of nuclear factor κB-mediated inflammatory pathways in cancer-related symptoms and their regulation by nutritional agents. Exp Biol Med (Maywood) 2011;236:658–71.10.1258/ebm.2011.011028Suche in Google Scholar PubMed PubMed Central

66. King EM, Chivers JE, Rider CF, Minnich A, Giembycz MA, Newton R. Glucocorticoid repression of inflammatory gene expression shows differential responsiveness by transactivation- and transrepression-dependent mechanisms. PLoS One 2013;8:e53936.10.1371/journal.pone.0053936Suche in Google Scholar PubMed PubMed Central

67. Lei K, Chen L, Georgiou EX, Sooranna SR, Khanjani S, Brosens JJ, Bennett PR, Johnson MR. Progesterone acts via the nuclear glucocorticoid receptor to suppress IL-1β-induced COX-2 expression in human term myometrial cells. PLoS One 2012;7:e5016710.1371/journal.pone.0050167Suche in Google Scholar PubMed PubMed Central

68. Kemik O, Kemik AS, Sumer A, Begenik H, Purisa S, Tuzun S, Kotan C. Relationship between clinicopathologic variables and serum and tissue levels of dickkopf-1 in patients with rectal cancer. J Invest Med 2011;59:947–50.10.2310/JIM.0b013e318224d8e4Suche in Google Scholar PubMed

69. Nakajima TE, Yamada Y, Hamano T, Furuta K, Matsuda T, Fujita S, Kato K, Hamaguchi T, Shimada Y. Adipocytokines as new promising markers of colorectal tumors: adiponectin for colorectal adenoma, and resistin and visfatin for colorectal cancer. Cancer Sci 2010;101:1286–91.10.1111/j.1349-7006.2010.01518.xSuche in Google Scholar PubMed

70. Smiechowska J, Utech A, Taffet G, Hayes T, Marcelli M, Garcia JM. Adipokines in patients with cancer anorexia and cachexia. J Invest Med 2010;58:554–9.10.2310/JIM.0b013e3181cf91caSuche in Google Scholar

71. Ntikoudi E, Kiagia M, Boura P, Syrigos KN. Hormones of adipose tissue and their biologic role in lung cancer. Cancer Treat Rev 2013. DOI: pii: S0305-7372(13)00128-X. 10.1016/j.ctrv.2013.06.005. [Epub ahead of print].Suche in Google Scholar

72. Machado AP, Costa Rosa LF, Seelaender MC. Adipose tissue in walker 256 tumour-induced cachexia: possible association between decreased leptin concentration and mononuclear cell infiltration. Cell Tissue Res 2004;318:503–14.10.1007/s00441-004-0987-2Suche in Google Scholar PubMed

73. Li P, Zhang XN, Pan CM, Sun F, Zhu DL, Song HD, Chen MD. Aldosterone perturbs adiponectin and pai-1 expression and secretion in 3t3-l1 adipocytes. Horm Metab Res 2011;43:464–9.10.1055/s-0031-1277226Suche in Google Scholar PubMed

74. Abelenda M, Puerta M. Leptin release is decreased in white adipocytes isolated from progesterone-treated rats. Endocr Res 2004;30:335–42.10.1081/ERC-200033198Suche in Google Scholar

75. von Haehling S, Stepney R, Anker SD. Advances in understanding and treating cardiac cachexia: highlights from the 5th cachexia conference. Int J Cardiol 2010;144:347–9.10.1016/j.ijcard.2010.05.042Suche in Google Scholar

76. Burney BO, Garcia JM. Hypogonadism in male cancer patients. J Cachexia Sarcopenia Muscle 2012;3:149–55.10.1007/s13539-012-0065-7Suche in Google Scholar

77. Burney BO, Hayes TG, Smiechowska J, Cardwell G, Papusha V, Bhargava P, Konda B, Auchus RJ, Garcia JM. Low testosterone levels and increased inflammatory markers in patients with cancer and relationship with cachexia. J Clin Endocrinol Metab 2012;97:E700–9.10.1210/jc.2011-2387Suche in Google Scholar

78. Attanasio P, Anker SD, Doehner W, von Haehling S. Hormonal consequences and prognosis of chronic heart failure. Curr Opin Endocrinol Diabetes Obes 2011;18:224–30.10.1097/MED.0b013e3283469505Suche in Google Scholar

79. Vigano A, Piccioni M, Trutschnigg B, Hornby L, Chaudhury P, Kilgour R. Male hypogonadism associated with advanced cancer: a systematic review. Lancet Oncol 2010;11:679–84.10.1016/S1470-2045(10)70021-8Suche in Google Scholar

80. Gautier A, Bonnet F, Dubois S, Massart C, Grosheny C, Bachelot A, Aube C, Balkau B, Ducluzeau PH. Associations between visceral adipose tissue, inflammation and sex steroid concentrations in men. Clin Endocrinol (Oxf) 2013;78:373–8.10.1111/j.1365-2265.2012.04401.xSuche in Google Scholar PubMed

81. Aaronson AJ, Morrissey RP, Nguyen CT, Willix R, Schwarz ER. Update on the safety of testosterone therapy in cardiac disease. Expert Opin Drug Saf 2011;10:697–704.10.1517/14740338.2011.566213Suche in Google Scholar PubMed

82. Storer TW, Woodhouse LJ, Sattler F, Singh AB, Schroeder ET, Beck K, Padero M, Mac P, Yarasheski KE, Geurts P, Willemsen A, Harms MK, Bhasin S. A randomized, placebo-controlled trial of nandrolone decanoate in human immunodeficiency virus-infected men with mild to moderate weight loss with recombinant human growth hormone as active reference treatment. J Clin Endocrinol Metab 2005;90:4474–82.10.1210/jc.2005-0275Suche in Google Scholar PubMed

83. Gullett NP, Hebbar G, Ziegler TR. Update on clinical trials of growth factors and anabolic steroids in cachexia and wasting. Am J Clin Nutr 2010;91:1143S–7S.10.3945/ajcn.2010.28608ESuche in Google Scholar PubMed PubMed Central

84. Bhasin S, Jasuja R. Selective androgen receptor modulators as function promoting therapies. Curr Opin Clin Nutr Metab Care 2009;12:232–40.10.1097/MCO.0b013e32832a3d79Suche in Google Scholar PubMed PubMed Central

85. Ruiz Garcia V, Lopez-Briz E, Carbonell Sanchis R, Gonzalvez Perales JL, Bort-Marti S. Megestrol acetate for treatment of anorexia-cachexia syndrome. Cochrane Database Syst Rev 2013;3:CD004310.10.1002/14651858.CD004310.pub3Suche in Google Scholar PubMed PubMed Central

86. Dev R, Hui D, Dalal S, Nooruddin ZI, Yennurajalingam S, Del Fabbro E, Bruera E. Association between serum cortisol and testosterone levels, opioid therapy, and symptom distress in patients with advanced cancer. J Pain Symptom Manage 2011;41:788–95.10.1016/j.jpainsymman.2010.06.021Suche in Google Scholar PubMed

87. Newman KP, Neal MT, Roberts M, Goodwin KD, Hatcher EA, Bhattacharya SK. The importance of lost minerals in heart failure. Cardiovasc Hematol Agents Med Chem 2007;5:295–9.10.2174/187152507782109872Suche in Google Scholar PubMed

88. Feraco A, Armani A, Mammi C, Fabbri A, Rosano GM, Caprio M. Role of mineralocorticoid receptor and renin-angiotensin-aldosterone system in adipocyte dysfunction and obesity. J Steroid Biochem Mol Biol 2013. DOI: pii: S0960-0760(13) 00043-5. 10.1016/j.jsbmb.2013.02.012. [Epub ahead of print].Suche in Google Scholar

89. Boonen E, Vervenne H, Meersseman P, Andrew R, Mortier L, Declercq PE, Vanwijngaerden YM, Spriet I, Wouters PJ, Vander Perre S, Langouche L, Vanhorebeek I, Walker BR, Van den Berghe G. Reduced cortisol metabolism during critical illness. N Engl J Med 2013;368:1477–88.10.1056/NEJMoa1214969Suche in Google Scholar PubMed PubMed Central

90. Barnes PJ, Celli BR. Systemic manifestations and comorbidities of COPD. Eur Respir J 2009;33:1165–85.10.1183/09031936.00128008Suche in Google Scholar PubMed

91. Gullett N, Rossi P, Kucuk O, Johnstone PA. Cancer-induced cachexia: a guide for the oncologist. J Soc Integr Oncol 2009;7:155–69.Suche in Google Scholar

Received: 2013-8-1
Accepted: 2013-9-25
Published Online: 2013-10-19
Published in Print: 2014-1-1

©2014 by Walter de Gruyter Berlin/Boston

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