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Synthesis and antifungal activity of dehydroabietic acid-based thiadiazole-phosphonates

  • Nai-Yuan Chen , Wen-Gui Duan EMAIL logo , Lu-Zhi Liu , Fang-Yao Li , Min-Ping Lu and Bu-Ming Liu
Published/Copyright: January 15, 2015
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Abstract

In search of new potent bioactive compounds, a series of dehydroabietic acid-based thiadiazole-phosphonate compounds were designed and synthesized by the Mannich-type reaction. All target compounds were characterized by Fourier transform infrared, 1H nuclear magnetic resonance (NMR), 13C NMR, 31P NMR, electrospray ionization-mass spectrometry, and UV-vis spectroscopy. The preliminary bioassay experiments showed that, at the concentration of 50 μg ml-1, some of the target compounds exhibited excellent antifungal activity against the five fungi tested, in which several compounds displayed even better antifungal effects than the commercial antifungal drug azoxystrobin, which served as the positive control in this study.


Corresponding author: Wen-Gui Duan, School of Chemistry and Chemical Engineering, Guangxi University, No. 100, Daxue Dong Road, Nanning 530004, P.R. China, e-mail:

Acknowledgments

The authors are grateful to the National Natural Science Foundation of China (No. 31060100), the Innovation Plan for Postgraduate Education of Guangxi, China (No. YCBZ2013001), and the Open Fund of Guangxi Key Laboratory of Traditional Chinese Medicine Quality Standards (No. guizhongzhongkai201203) for the financial support. We are also thankful to the Research Institute of Elemento-organic Chemistry, Nankai University, China, for the bioassay test.

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Received: 2014-10-22
Accepted: 2014-12-10
Published Online: 2015-1-15
Published in Print: 2015-11-1

©2015 by De Gruyter

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