Abstract
In search of new potent bioactive compounds, a series of dehydroabietic acid-based thiadiazole-phosphonate compounds were designed and synthesized by the Mannich-type reaction. All target compounds were characterized by Fourier transform infrared, 1H nuclear magnetic resonance (NMR), 13C NMR, 31P NMR, electrospray ionization-mass spectrometry, and UV-vis spectroscopy. The preliminary bioassay experiments showed that, at the concentration of 50 μg ml-1, some of the target compounds exhibited excellent antifungal activity against the five fungi tested, in which several compounds displayed even better antifungal effects than the commercial antifungal drug azoxystrobin, which served as the positive control in this study.
Acknowledgments
The authors are grateful to the National Natural Science Foundation of China (No. 31060100), the Innovation Plan for Postgraduate Education of Guangxi, China (No. YCBZ2013001), and the Open Fund of Guangxi Key Laboratory of Traditional Chinese Medicine Quality Standards (No. guizhongzhongkai201203) for the financial support. We are also thankful to the Research Institute of Elemento-organic Chemistry, Nankai University, China, for the bioassay test.
References
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©2015 by De Gruyter
Articles in the same Issue
- Frontmatter
- Original Articles
- Cloning and expression of a sesquiterpene synthase gene from Taiwania cryptomerioides
- Stabilization, degradation, and dissolution behavior of Scots pine polysaccharides during polysulfide (K-PS) and polysulfide anthraquinone (K-PSAQ) pulping
- Swelling, viscoelastic, and anatomical studies on ionic liquid-swollen Norway spruce as a screening tool toward ionosolv pulping
- Synthesis and antifungal activity of dehydroabietic acid-based thiadiazole-phosphonates
- Nanofibrillation of TEMPO-oxidized bleached hardwood kraft cellulose at high solids content
- Free radical gelling reactions of lignosulfonates
- Preparation of electrode for electric double layer capacitor from electrospun lignin fibers
- Standard and non-standard deformation behaviour of European beech and Norway spruce during compression
- Determination of log moisture content using ground penetrating radar (GPR). Part 1. Partial least squares (PLS) method
- Determination of log moisture content using ground penetrating radar (GPR). Part 2. Propagation velocity (PV) method
- Improved method based on dual-energy X-ray absorptiometry for nondestructive evaluation of solid wood moisture content
- A comparative study of dewatering of Pinus radiata sapwood using supercritical CO2 and conventional forced air-drying via in situ magnetic resonance microimaging (MRI)
- Influence of exposure time, wood species and dimension on the remaining copper and chromium content in CC-treated wood after field and laboratory leaching tests
Articles in the same Issue
- Frontmatter
- Original Articles
- Cloning and expression of a sesquiterpene synthase gene from Taiwania cryptomerioides
- Stabilization, degradation, and dissolution behavior of Scots pine polysaccharides during polysulfide (K-PS) and polysulfide anthraquinone (K-PSAQ) pulping
- Swelling, viscoelastic, and anatomical studies on ionic liquid-swollen Norway spruce as a screening tool toward ionosolv pulping
- Synthesis and antifungal activity of dehydroabietic acid-based thiadiazole-phosphonates
- Nanofibrillation of TEMPO-oxidized bleached hardwood kraft cellulose at high solids content
- Free radical gelling reactions of lignosulfonates
- Preparation of electrode for electric double layer capacitor from electrospun lignin fibers
- Standard and non-standard deformation behaviour of European beech and Norway spruce during compression
- Determination of log moisture content using ground penetrating radar (GPR). Part 1. Partial least squares (PLS) method
- Determination of log moisture content using ground penetrating radar (GPR). Part 2. Propagation velocity (PV) method
- Improved method based on dual-energy X-ray absorptiometry for nondestructive evaluation of solid wood moisture content
- A comparative study of dewatering of Pinus radiata sapwood using supercritical CO2 and conventional forced air-drying via in situ magnetic resonance microimaging (MRI)
- Influence of exposure time, wood species and dimension on the remaining copper and chromium content in CC-treated wood after field and laboratory leaching tests