Exposure of nano- and ultrafine Ni particles to synthetic biological solutions: predicting fate-related dissolution and accumulation

Diana Abzhanova; Anna Godymchuk; Alexander Gusev; Denis Kuznetsov

doi:10.1515/ejnm-2016-0021

Article

Exposure of nano- and ultrafine Ni particles to synthetic biological solutions: predicting fate-related dissolution and accumulation

Diana Abzhanova
Diana Abzhanova received her Master Degree in Material Science and Technology of Materials from the Tomsk Polytechnic University in 2014. Her research focuses on the investigation of nanomaterials properties in simulated body fluids.
, Anna Godymchuk
Anna Godymchuk works as an Associate Professor and gives courses on occupational and environmental health risk and potential hazard of engineered nanoparticles. As a scientist she is mainly focused on the in vitro study of nanoscale particle aggregation and dissolution and physicochemical characterization of nanopowders in aqueous suspensions. She is the author and co-author of 20 research papers.
, Alexander Gusev
Alexander Gusev research interests are in nanobiointeractions and nanotoxicology of carbon, metallic and oxide nanoparticles. He has published over 30 peerreviewed articles, over 50 conference proceedings, textbooks and holds two patents.
and Denis Kuznetsov
Denis Kuznetsov is employed at National University of Science and Technology “MISiS”. During last 20 years his scientific activity has been focused in the area of synthesis, characterization and practical applications of various types of nanomaterials. His current research interests include procedures of evaluating of toxic effects of metal nanopowders and carbon based nanomaterials.

Published/Copyright: November 26, 2016

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From the journal European Journal of Nanomedicine Volume 8 Issue 4

Abstract

The growing production and use of nickel (Ni) nanopowders with low biopersistence makes dissolution and accumulation degree in a body an important parameters needed for the risk assessment of nanoparticles. We propose an experimental approach for rapid determination of the dissolution degree of nanoscale (77 nm) and ultrafine (275 nm) Ni particles in synthetic biological solutions. It has been shown that after 2 h of exposure to simulating saliva and lysosomal liquid the dissolution degree of nanoparticles can reach 30 and 60 wt.%, respectively. With decreasing of the particle’s size, they are characterized by increased solubility in saliva and the pulmonary tract; and the particles completely dissolve in 24 h. There was an attempt to predict the potential extent of accumulation of nickel compounds in the human body with particles entering the body by saliva or with breathing: with 3.8 times size decrease the probability of nickel accumulation in a body can rise in 3.5 times.

Keywords: accumulation; dissolution; lysosomal liquid; nanoparticles risk assessment; nickel nanoparticles; synthetic saliva

About the authors

Diana Abzhanova

Diana Abzhanova received her Master Degree in Material Science and Technology of Materials from the Tomsk Polytechnic University in 2014. Her research focuses on the investigation of nanomaterials properties in simulated body fluids.

Anna Godymchuk

Anna Godymchuk works as an Associate Professor and gives courses on occupational and environmental health risk and potential hazard of engineered nanoparticles. As a scientist she is mainly focused on the in vitro study of nanoscale particle aggregation and dissolution and physicochemical characterization of nanopowders in aqueous suspensions. She is the author and co-author of 20 research papers.

Alexander Gusev

Alexander Gusev research interests are in nanobiointeractions and nanotoxicology of carbon, metallic and oxide nanoparticles. He has published over 30 peerreviewed articles, over 50 conference proceedings, textbooks and holds two patents.

Denis Kuznetsov

Denis Kuznetsov is employed at National University of Science and Technology “MISiS”. During last 20 years his scientific activity has been focused in the area of synthesis, characterization and practical applications of various types of nanomaterials. His current research interests include procedures of evaluating of toxic effects of metal nanopowders and carbon based nanomaterials.

Acknowledgments

The work was supported by the Russian Fund for Basic Research (project # 15-03-06528_a). SEM-images of nickel nanopowder were kindly provided by Dr. Aleksey Shuklinov, Nano-Centre of Tambov Derzhavin State University, Russia.

Conflict of interest statement: Authors state no conflict of interest. All authors have read the journal’s Publication ethics and publication malpractice statement available at the journal’s website and hereby confirm that they comply with all its parts applicable to the present scientific work.

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Received: 2016-7-15

Accepted: 2016-10-31

Published Online: 2016-11-26

Published in Print: 2016-10-1

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Articles in the same Issue

https://doi.org/10.1515/ejnm-2016-0021

Keywords for this article

accumulation; dissolution; lysosomal liquid; nanoparticles risk assessment; nickel nanoparticles; synthetic saliva