Crede’s method in eye water finds a nanomedicine base: a potential candidate to control ophthalmia neonatorum
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Anupam Roy
Anupam Roy is pursuing his PhD at the Agricultural and Food Engineering Department, Indian Institute of Technology Kharagpur, India. His area of research is the application of nanotechnology in developing advanced bio-molecules for food applications. At present he is working as an Assistant Professor in the Department of Chemical Engineering and Technology, Birla Institute of Technology Mesra, Jharkhand, India.
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Shanker L. Shrivastava
Suman Saha has been working as a consultant microbiologist at the Ocular Microbiology and Molecular Biology Laboratory at Priyamvada Birla Aravind Eye Hospital, Kolkata for 9 years. His area of research focuses on ophthalmic diseases and their drug resistance. He has published in reputed international journals and presented his research papers in various international forums.
Malabendu Jana completed his PhD at the Department of Chemistry and Technology, Vidyasagar University, West Bengal, India. He is now investigating the molecular mechanisms involved in different neurodegenerative diseases such as multiple sclerosis (MS), Alzheimer’s disease (AD), Parkinson’s disease (PD), and HIV-associated dementia (HAD). At present he is working as an Assistant Professor in the Department of Neurological Sciences, Rush University Medical Center, Chicago, IL-60612, USA.
Santi M. Mandal obtained his PhD in the field of Molecular Microbiology and is continuing his research with major focus on antimicrobial chemotherapy. Recently, he has been working at the Central Research Facility of IIT-Khragpur, India. He has published more than 90 research papers in reputed journals and has been the recipient of several prestigious awards for his research contribution.
Abstract
Lethal eye infections of newborns occur mostly due to their passage through the contaminated birth canal. In the pre-antibiotic era blindness from such infections was most challenging. This scenario changed after the 1880s with the use of Crede’s method (a drop of 2.0% silver nitrate solution into newborn’s eyes which was later reduced to 1.0%). This research is focused on finding the structure-function relationship between silver nitrate and tears which offer antimicrobial action. A reinvestigation of Crede’s method revealed a light-dependent instant formation of silver oxide nanoparticles (sizes 20–70 nm) with strong antimicrobial action against ocular pathogens. Nano-therapy would be the key reason behind the widely accepted use of silver nitrate eye drop as a prophylactic agent prior to the discovery of antibiotics. A scientific view on the age-old Crede’s method explores the use of nano-therapy as a prophylactic agent. When routine prophylaxis with topical antibiotics brings the risk of resistance, Crede’s method may, in the near future, offer a way to fight against ophthalmia neonatorum (ON) caused by antibiotic-resistant pathogens.
About the authors
Anupam Roy is pursuing his PhD at the Agricultural and Food Engineering Department, Indian Institute of Technology Kharagpur, India. His area of research is the application of nanotechnology in developing advanced bio-molecules for food applications. At present he is working as an Assistant Professor in the Department of Chemical Engineering and Technology, Birla Institute of Technology Mesra, Jharkhand, India.
Suman Saha has been working as a consultant microbiologist at the Ocular Microbiology and Molecular Biology Laboratory at Priyamvada Birla Aravind Eye Hospital, Kolkata for 9 years. His area of research focuses on ophthalmic diseases and their drug resistance. He has published in reputed international journals and presented his research papers in various international forums.
Malabendu Jana completed his PhD at the Department of Chemistry and Technology, Vidyasagar University, West Bengal, India. He is now investigating the molecular mechanisms involved in different neurodegenerative diseases such as multiple sclerosis (MS), Alzheimer’s disease (AD), Parkinson’s disease (PD), and HIV-associated dementia (HAD). At present he is working as an Assistant Professor in the Department of Neurological Sciences, Rush University Medical Center, Chicago, IL-60612, USA.
Santi M. Mandal obtained his PhD in the field of Molecular Microbiology and is continuing his research with major focus on antimicrobial chemotherapy. Recently, he has been working at the Central Research Facility of IIT-Khragpur, India. He has published more than 90 research papers in reputed journals and has been the recipient of several prestigious awards for his research contribution.
Conflict of interest statement: Authors state no conflict of interest. All authors have read the journal’s Publication ethics and publication malpractice statement available at the journal’s website and hereby confirm that they comply with all its parts applicable to the present scientific work.
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Supplemental Material:
The online version of this article (DOI: 10.1515/ejnm-2016-0017) offers supplementary material, available to authorized users.
©2016 Walter de Gruyter GmbH, Berlin/Boston
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Articles in the same Issue
- Frontmatter
- In this issue
- Guest Editorial
- Nanomaterials for medicine: benefits and risks
- Original Articles
- Synthesis and surface characterization of nanosized Y2O3:Eu and YAG:Eu luminescent phosphors which are useful in photodynamic therapy of cancer
- Benzyldimethyl[3-(miristoylamino)-propyl]ammonium chloride stabilized silver nanoparticles (Argumistin™) in medicine: results of clinical trials for treatment of infectious diseases of dogs and perspectives for humans
- Preparation of electroconductive aluminum-silicon oxide ceramic sensors modified with silver and bismuth nanoparticles
- Exposure of nano- and ultrafine Ni particles to synthetic biological solutions: predicting fate-related dissolution and accumulation
- Regular contributions
- Original Article
- Exposure to bleomycin nanoaerosol does not induce fibrosis in mice
- Short Communications
- The use of objective oriented project planning tools for nanosafety and health concerns: a case study in nanomedicine research project
- Crede’s method in eye water finds a nanomedicine base: a potential candidate to control ophthalmia neonatorum
