Startseite Medizin Radio-nanomaterials for biomedical applications: state of the art
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Radio-nanomaterials for biomedical applications: state of the art

  • Weifei Lu

    Weifei Lu acquired his PhD degree in Biochemistry from Henan Agriculture University (HAU), China in 2014 and is currently an Associate Professor in HAU. As an active member of Chinese Society of Biochemistry and Molecular Biology, his research interest is focused on the development of gene therapy vectors, study of gene functions, protein engineering, and targeted drug delivery. He is now a visiting professor under the supervision of Dr. Hao Hong for design and synthesis of novel PET tracers based on biodegradable nanomaterials and engineered proteins. He also participates actively in different major research projects funded by NSF China.

         , Hao Hong

    Hao Hong started his postion as a Research Assistant Professor of Radiology at the University of Michigan in 2014. He received his PhD degree in Biochemistry and Molecular Biology from Nanjing University (P.R. China) in 2008. He acquired his postdoctoral training from 2008 to 2013 in the Department of Radiology, University of Wisconsin, Madison. His research interest is in the design and optimization of new imaging tracers for cancer as well as modification/application of nanomaterials for image-guided therapeutic delivery. Dr. Hong has published >90 peer-reviewed manuscripts (citation >3400 in Google scholar) and received many awards.

     EMAIL logo     und Weibo Cai

    Weibo Cai is currently an Associate Professor of Radiology and Medical Physics at the University of Wisconsin-Madison. He received his PhD in Chemistry from UC San Diego in 2004. After postdoctoral training at Stanford University, he launched his career at UW-Madison in early 2008. His research is primarily focused on molecular imaging and nanotechnology (http://mi.wisc.edu/), investigating the biomedical applications of various agents developed in his laboratory for imaging and therapy of cancer and cardiovascular diseases. Dr. Cai has authored ~200 peer-reviewed publications with H-index of >50, received many awards, and served on numerous grant review panels.

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Veröffentlicht/Copyright: 2. Juni 2016
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European Journal of Nanomedicine
Aus der Zeitschrift European Journal of Nanomedicine Band 8 Heft 3

Abstract

The incorporation of radioactive isotope(s) into conventional nanomaterials can bring extra properties which are not possessed by original materials. The resulting radioactive nanomaterials (radio-nanomaterials), with added physical/chemical properties, can be used as important tools for different biomedical applications. In this review, our goal is to provide an up-to-date overview on these applications using radio-nanomaterials. The first section illustrates the utilization of radio-nanomaterials for understanding of in vivo kinetics of their parent nanomaterials. In the second section, we focus on two primary applications of radio-nanomaterials: imaging and therapeutic delivery. With various methods being used to form radio-nanomaterials, they can be used for positron emission tomography (PET), single-photon emission computed tomography (SPECT), and multimodal imaging. Therapeutic isotopes-loading radio-nanomaterials can possess selective killing efficacy of diseased cells (e.g. tumor cells) and can provide promises for certain isotopes which are not able to be used in a conventional manner. The successful and versatile biomedical applications of radio-nanomaterials warrants further investigations of those materials and their optimizations can pave the way to future imaging guidable, personalized treatments in patients.

Keywords: in vivo distribution; positron emission tomography; radiation therapy; radioactive nanomaterials; radiolabel; single-photon emission computed tomography

Funding source: National Institutes of Health

Award Identifier / Grant number: NIBIB/NCI R01CA169365

Award Identifier / Grant number: P30CA014520

Funding source: American Cancer Society

Award Identifier / Grant number: 125246-RSG-13-099-01-CCE

Funding statement: This work was supported, in part, by the National Institutes of Health (NIBIB/NCI R01CA169365, P30CA014520), the American Cancer Society (125246-RSG-13-099-01-CCE), and the Pardee Foundation Grant (to H.H.).

About the authors

Weifei Lu

Weifei Lu acquired his PhD degree in Biochemistry from Henan Agriculture University (HAU), China in 2014 and is currently an Associate Professor in HAU. As an active member of Chinese Society of Biochemistry and Molecular Biology, his research interest is focused on the development of gene therapy vectors, study of gene functions, protein engineering, and targeted drug delivery. He is now a visiting professor under the supervision of Dr. Hao Hong for design and synthesis of novel PET tracers based on biodegradable nanomaterials and engineered proteins. He also participates actively in different major research projects funded by NSF China.

Hao Hong

Hao Hong started his postion as a Research Assistant Professor of Radiology at the University of Michigan in 2014. He received his PhD degree in Biochemistry and Molecular Biology from Nanjing University (P.R. China) in 2008. He acquired his postdoctoral training from 2008 to 2013 in the Department of Radiology, University of Wisconsin, Madison. His research interest is in the design and optimization of new imaging tracers for cancer as well as modification/application of nanomaterials for image-guided therapeutic delivery. Dr. Hong has published >90 peer-reviewed manuscripts (citation >3400 in Google scholar) and received many awards.

Weibo Cai

Weibo Cai is currently an Associate Professor of Radiology and Medical Physics at the University of Wisconsin-Madison. He received his PhD in Chemistry from UC San Diego in 2004. After postdoctoral training at Stanford University, he launched his career at UW-Madison in early 2008. His research is primarily focused on molecular imaging and nanotechnology (http://mi.wisc.edu/), investigating the biomedical applications of various agents developed in his laboratory for imaging and therapy of cancer and cardiovascular diseases. Dr. Cai has authored ~200 peer-reviewed publications with H-index of >50, received many awards, and served on numerous grant review panels.

Acknowledgments

This work was supported, in part, by the National Institutes of Health (NIBIB/NCI R01CA169365, P30CA014520), the American Cancer Society (125246-RSG-13-099-01-CCE), and the Pardee Foundation Grant (to H.H.).

  1. Conflict of interest statement: The authors state no conflict of interest. All authors have read the journal’s publication ethics and publication malpractice statement available at the journal’s website and hereby confirm that they comply with all its parts applicable to the present scientific work.

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Received: 2016-4-18
Accepted: 2016-5-3
Published Online: 2016-6-2
Published in Print: 2016-7-1

©2016 by De Gruyter

Artikel in diesem Heft

  1. Frontmatter
  2. In this issue
  3. News
  4. CLINAM 2016 summit June 26–29, 2016
  5. Special section Nanotechnology for infectious diseases
  6. Editorial
  7. Nanomedicine translation from enabling technologies to the patient: focus on infectious diseases
  8. Critical Review
  9. Improving diagnosis of pneumococcal disease by multiparameter testing and micro/nanotechnologies
  10. Original Articles
  11. Solid lipid nanoparticles encapsulating a fluorescent marker (coumarin 6) and antimalarials – artemether and lumefantrine: evaluation of cellular uptake and antimalarial activity
  12. Nano-mupirocin: enabling the parenteral activity of mupirocin
  13. Regular contributions
  14. Review
  15. Radio-nanomaterials for biomedical applications: state of the art
https://doi.org/10.1515/ejnm-2016-0011
Schlagwörter für diesen Artikel
in vivo distribution; positron emission tomography; radiation therapy; radioactive nanomaterials; radiolabel; single-photon emission computed tomography

Artikel in diesem Heft

  1. Frontmatter
  2. In this issue
  3. News
  4. CLINAM 2016 summit June 26–29, 2016
  5. Special section Nanotechnology for infectious diseases
  6. Editorial
  7. Nanomedicine translation from enabling technologies to the patient: focus on infectious diseases
  8. Critical Review
  9. Improving diagnosis of pneumococcal disease by multiparameter testing and micro/nanotechnologies
  10. Original Articles
  11. Solid lipid nanoparticles encapsulating a fluorescent marker (coumarin 6) and antimalarials – artemether and lumefantrine: evaluation of cellular uptake and antimalarial activity
  12. Nano-mupirocin: enabling the parenteral activity of mupirocin
  13. Regular contributions
  14. Review
  15. Radio-nanomaterials for biomedical applications: state of the art
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