Spinal and general anesthesia produces differential effects on oxidative stress and inflammatory cytokines in orthopedic patients
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Peter A. Aremu
Abstract
Objectives
The contribution of anesthetic procedure to surgical stress and postoperative complications has been attributed to increased oxidative stress and release of inflammatory cytokines. Thus, the levels of oxidative stress biomarkers and inflammatory cytokines in patients with general anesthesia (GA) and spinal anesthesia (SA) that underwent open reduction and internal fixation (ORIF) in orthopedic surgery at Federal Teaching Hospital, Ido-Ekiti, Ekiti state, Nigeria were investigated.
Methods
Forty patients were randomly distributed into two groups (n = 20) namely GA and SA. Blood samples were collected before and after surgery for estimation of glucose, oxidative stress biomarkers (malondialdehyde [MDA], glutathione, catalase and nitrile) and inflammatory cytokines (tumor necrosis factor-α [TNF-α] and interleukin-6) levels.
Results
The post-operative blood glucose level was higher than the pre-operative value (p<0.5) in the two groups. There were significant (p<0.05) changes in MDA concentration and catalase activity in patients with GA in the post-operative stage relative to preoperative phase. There were no significant differences in glutathione, nitrite and interleukin-6 contents between the two groups. The patients with SA had higher levels of TNF-α in the post-operative stage.
Conclusions
These findings suggest that anesthesia has differential effects on oxidative stress and inflammatory cytokines in patients with ORIF orthopedic surgery.
Acknowledgments
The authors thank the technical staff of the Department of Pharmacology and Therapeutics, University of Ibadan, Ibadan for their assistance. Authors are also grateful to the patients for their voluntary participation in the study.
Research funding: None declared.
Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
Competing interests: Authors state no conflict of interest.
Informed consent: Informed consent was obtained from all individuals included in this study.
Ethical approval: Ethical approval was obtained from the Ethical Committee of Federal Teaching Hospital, Ido-Ekiti, Ekiti State (ECR/2017/07/03/63B).
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- Frontmatter
- Review
- Herbal approach for the management of C0VID-19: an overview
- Original Articles
- Clinically important drug–drug interactions in patients admitted to hospital with COVID-19: drug pairs, risk factors, and management
- Spinal and general anesthesia produces differential effects on oxidative stress and inflammatory cytokines in orthopedic patients
- Immunogenicity of antitumor necrosis factor therapy in patients with spondyloarthritis
- Biochip-based approach for comprehensive pharmacogenetic testing
- Clinical efficacy of Majoon Falasfa and Roghan-e-Surkh in post-stroke-disability: an open labeled, pre-post analysis
- Ascorbic acid improves extrapyramidal syndromes and corpus striatal degeneration induced by dopamine-2 receptor inhibition in Wistar rats
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