CYP2D6 variability in populations from Venezuela
-
Nancy Moreno
,
Carlos Flores-Angulo
Abstract
CYP2D6 is an important cytochrome P450 enzyme that plays an important role in the metabolism of about 25% of currently prescribed drugs. The presence of polymorphisms in the CYP2D6 gene may modulate enzyme level and activity, thereby affecting individual responses to pharmacological treatments. The most prevalent diseases in the admixed population from Venezuela are cardiovascular and cancer, whereas viral, bacterial and parasitic diseases, particularly malaria, are prevalent in Amerindian populations; in the treatment of these diseases, several drugs that are metabolized by CYP2D6 are used. In this work, we reviewed the data on CYP2D6 variability and predicted metabolizer phenotypes, in healthy volunteers of two admixed and five Amerindian populations from Venezuela. The Venezuelan population is very heterogeneous as a result of the genetic admixture of three major ethnical components: Europeans, Africans and Amerindians. There are noticeable inter-regional and inter-population differences in the process of mixing of this population. Hitherto, there are few published studies in Venezuela on CYP2D6; therefore, it is necessary to increase research in this regard, in particular to develop studies with a larger sample size. There is a considerable amount of work remaining before CYP2D6 is integrated into clinical practice in Venezuela.
Acknowledgments
We are grateful to Dr. Flor Herrera from Instituto de Investigaciones Biomédicas “Dr. Francisco J. Triana Alonso” for useful suggestions. I would like to thank Prof. Willie Peterson for revising the English in the manuscript.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved the submission.
Research funding: This study was financed by Fondo Nacional de Ciencia y Tecnología (FONACIT) through of the project N° 2012001248.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
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©2016 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Editorial
- The Santorini Conferences continue
- Mini Reviews
- CYP2D6 variability in populations from Venezuela
- Can pharmacogenetics help patients under chronic treatment with coumarin anticoagulants?
- Pharmacogenetic studies: a tool to improve antidepressant therapy
- Original Articles
- 1846G>A polymorphism of CYP2D6 gene and extrapyramidal side effects during antipsychotic therapy among Russians and Tatars: a pilot study
- SLC22A2 – mapping genomic variations within South African indigenous and admixed populations
- Improvement of the chemical inhibition phenotyping assay by cross-reactivity correction
- Enhanced oral bioavailability of metoprolol with gallic acid and ellagic acid in male Wistar rats: involvement of CYP2D6 inhibition
- Case Report
- Vancomycin-induced thrombocytopenia in a newborn
- Acknowledgment
- Acknowledgment
- Congress Abstracts
- 8th Santorini Conference Systems Medicine and Personalised Health and Therapy
Articles in the same Issue
- Frontmatter
- Editorial
- The Santorini Conferences continue
- Mini Reviews
- CYP2D6 variability in populations from Venezuela
- Can pharmacogenetics help patients under chronic treatment with coumarin anticoagulants?
- Pharmacogenetic studies: a tool to improve antidepressant therapy
- Original Articles
- 1846G>A polymorphism of CYP2D6 gene and extrapyramidal side effects during antipsychotic therapy among Russians and Tatars: a pilot study
- SLC22A2 – mapping genomic variations within South African indigenous and admixed populations
- Improvement of the chemical inhibition phenotyping assay by cross-reactivity correction
- Enhanced oral bioavailability of metoprolol with gallic acid and ellagic acid in male Wistar rats: involvement of CYP2D6 inhibition
- Case Report
- Vancomycin-induced thrombocytopenia in a newborn
- Acknowledgment
- Acknowledgment
- Congress Abstracts
- 8th Santorini Conference Systems Medicine and Personalised Health and Therapy
