Vancomycin-induced thrombocytopenia in a newborn

Kunal Kalra; Hema Gupta Mittal; Arti Maria

doi:10.1515/dmpt-2016-0021

Article

Vancomycin-induced thrombocytopenia in a newborn

Kunal Kalra , Hema Gupta Mittal and Arti Maria

Published/Copyright: November 16, 2016

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From the journal Drug Metabolism and Personalized Therapy Volume 31 Issue 4

Abstract

Neonatal thrombocytopenia is common and is frequently seen in neonatal sepsis. Drug-induced thrombocytopenia is likely to be missed unless a high index of suspicion is present. Changing of antibiotics for assumed nonresolution of sepsis may lead to persistent thrombocytopenia in a neonate if drug-induced thrombocytopenia is missed. Vancomycin-induced neonatal thrombocytopenia is rarely described in scientific literature. We describe a newborn who was diagnosed with early onset sepsis and vancomycin-induced thrombocytopenia. Other causes of thrombocytopenia such as sepsis, alloimmune thrombocytopenia, thrombosis etc. were excluded. The platelet counts normalized within 72 h of stopping vancomycin. Vancomycin-induced IgM platelet antibodies could not be done in our case (due to financial constraints), but their absence does not exclude the diagnosis of vancomycin-induced thrombocytopenia.

Keywords: adverse effects; drugs; neonate; thrombocytopenia; vancomycin

Corresponding author: Dr. Hema Gupta Mittal, Department of Pediatrics, Dr. RML Hospital, New Delhi-1, India

Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

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Received: 2016-7-9

Accepted: 2016-9-13

Published Online: 2016-11-16

Published in Print: 2016-12-1

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Articles in the same Issue

https://doi.org/10.1515/dmpt-2016-0021

Keywords for this article

adverse effects; drugs; neonate; thrombocytopenia; vancomycin