Techno-economic assessment of medical oxygen production: cryogenic vs. PSA technologies
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Lina Benkirane
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Tarik Chafik
Abstract
This work presents a techno-economic comparison of medical oxygen production using cryogenic air separation and pressure swing adsorption technology. Process simulations were performed with Aspen Plus and Aspen Adsorption, and cost estimation was carried out using Aspen Process Economic Analyzer. For a production capacity of 1,000 t/year, the cryogenic process required a capital investment of 15.67 million USD and annual operating costs of 5.12 million USD, yielding an annual cash flow of 4.88 million USD, a payback period of 3.21 years, a net present value of 2.84 million USD, and a return on investment of 155.9 %. The PSA unit, designed for 500 t/year, required a CAPEX of 9.07 million USD and an OPEX of 2.05 million USD/year, achieving an annual cash flow of 7.94 million USD, a payback of 1.14 years, an NPV of 21.05 million USD, and an ROI of 437.87 %. Sensitivity analysis confirmed the strong dependence of cryogenic plants on electricity prices, while PSA exhibited high resilience to cost fluctuations. Overall, PSA offers superior economic feasibility for decentralized oxygen supply, whereas cryogenic separation remains advantageous for large-scale, high-purity production.
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Research ethics: Not applicable.
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Informed consent: Not applicable.
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Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Use of Large Language Models, AI and Machine Learning Tools: None declared.
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Conflict of interest: The authors state no conflict of interest.
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Research funding: None declared.
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Data availability: Not applicable.
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Software availability: Simulation work was carried out using Aspen Plus and Aspen Adsorption (AspenTech). Software is commercially available under license.
References
1. Burdyny, T, Struchtrup, H. Hybrid membrane/cryogenic separation of oxygen from air for use in the oxy-fuel process. Energy 2010;35:1884–97. https://doi.org/10.1016/j.energy.2009.12.033.Suche in Google Scholar
2. Bucsa, S, Serban, A, Balan, MC, Ionita, C, Nastase, G, Dobre, C, et al.. Exergetic analysis of a cryogenic air separation unit. Entropy 2022;24:272. https://doi.org/10.3390/e24020272.Suche in Google Scholar PubMed PubMed Central
3. Akbarian Shourkaei, M, Rashidi, A, Karimi-Sabet, J. Life cycle assessment of oxygen-18 production using cryogenic oxygen distillation. Chin J Chem Eng 2018;26:1960–6. https://doi.org/10.1016/j.cjche.2017.12.008.Suche in Google Scholar
4. Mmldigi. VPSA vs. PSA: different gas separation technology in oxygen generation. Jalon. https://www.jalonzeolite.com/vpsa-vs-psa-different-gas-separation-technology-in-oxygen-generation/ [Accessed 10 Oct 2022].Suche in Google Scholar
5. Abdel-Rahman, ZA, Ali, AJ. A study of oxygen separation from air by pressure swing adsorption. Univ Sci A 2010;3:45–54.Suche in Google Scholar
6. Santos, JC, Cruz, P, Regala, T, Magalhães, FD, Mendes, A. High-purity oxygen production by pressure swing adsorption. Ind Eng Chem Res. https://doi.org/10.1021/ie060400g.Suche in Google Scholar
7. Portillo, E, Gallego Fernández, LM, Cano, M, Alonso-Fariñas, B, Navarrete, B. Techno-economic comparison of integration options for an oxygen transport membrane unit into a coal oxy-fired circulating fluidized bed power plant. Membranes 2022;12:1224. https://doi.org/10.3390/membranes12121224.Suche in Google Scholar PubMed PubMed Central
8. Dionysios, SK, Evangelos, PF. Membranes targeting industrial O2 production from air – a short review. Int J Membr Sci Technol 2022;9:14–24. https://doi.org/10.15379/2410-1869.2022.02.Suche in Google Scholar
9. Ebrahimi, A, Meratizaman, M, Akbarpour Reyhani, H, Pourali, O, Amidpour, M. Energetic, exergetic and economic assessment of oxygen production from two columns cryogenic air separation unit. Energy 2015;90:1298–316. https://doi.org/10.1016/j.energy.2015.06.083.Suche in Google Scholar
10. Micari, M, Agrawal, KV. Oxygen enrichment of air: performance guidelines for membranes based on techno-economic assessment. J Membr Sci 2021;641:119883. https://doi.org/10.1016/j.memsci.2021.119883.Suche in Google Scholar
11. World Health Organization (WHO). Oxygen – Global. https://www.who.int/health-topics/oxygen [Accessed 17 Mar 2023].Suche in Google Scholar
12. ResearchAndMarkets.com. Global medical oxygen market (2020 to 2026) – by form, purity, delivery mode, modality, technology, application, end-user and region. https://www.businesswire.com/news/home/20210504005728/en/Global-Medical-Oxygen-Market-2020-to-2026---by-Form-Purity-Delivery-Mode-Modality-Technology-Application-End-user-and-Region---ResearchAndMarkets.com [Accessed 17 Mar 2023].Suche in Google Scholar
13. U.S. trade and commercial guide. Morocco - Healthcare. https://www.trade.gov/country-commercial-guides/morocco-healthcare [Accessed 2023 Mar 18].Suche in Google Scholar
14. Jha, M, Gaur, N. Life cycle of medical oxygen from production to consumption. J Fam Med Prim Care 2022;11:1231–6. https://doi.org/10.4103/jfmpc.jfmpc_956_21.Suche in Google Scholar PubMed PubMed Central
15. World Health Organization. Technical specifications for pressure swing adsorption, PSA oxygen plants, interim guidance. Geneva: WHO; 2020.Suche in Google Scholar
16. Salunkhe, NS, Sayyed, SS, Mote, VA, Ingole, MPM. A comparative study of air separation technologies: cryogenic and non-cryogenic processes. Processes 2022;8.Suche in Google Scholar
17. Alavandi, S, Seaba, J, Subbaraman, G. Emerging and existing oxygen production technology: Scan and evaluation. Gas Technology Institute Technical Report, GTI Project No. 22164;2018:1–102pp. Available from: https://www.gti.energy.Suche in Google Scholar
18. Bałys, M, Brodawka, E, Korzeniewska, A, Szczurowski, J, Zarębska, K. LCA and economic study on the local oxygen supply in central Europe during the COVID-19 pandemic. Sci Total Environ 2021;786:147401. https://doi.org/10.1016/j.scitotenv.2021.147401.Suche in Google Scholar PubMed PubMed Central
19. Skorek-Osikowska, A, Bartela, Ł, Kotowicz, J. A comparative thermodynamic, economic and risk analysis concerning implementation of oxy-combustion power plants integrated with cryogenic and hybrid air separation units. Energy Convers Manag 2015;92:421–30. https://doi.org/10.1016/j.enconman.2014.12.079.Suche in Google Scholar
20. The Bureau of Investigative Journalism. Explainer: how medical oxygen is made. https://www.thebureauinvestigates.com/stories/2021-05-25/how-medical-oxygen-is-made [Accessed 17 Mar 2023].Suche in Google Scholar
21. Procurement Resource. Oxygen production cost analysis; 2023. https://www.procurementresource.com/production-cost-report-store/oxygen [Accessed 18 Mar 2023].Suche in Google Scholar
22. Wood, KR, Liu, Y, Yu, Y. Design, simulation and optimization of adsorptive and chromatographic separations: a Hands-on approach. Weinheim, Germany: Wiley VCH; 2018.10.1002/9783527815029Suche in Google Scholar
23. Generon. Buy PSA oxygen generator | pressure swing adsorption O2 generators. https://www.generon.com/product/psa-oxygen-generator/ [Accessed 29 Oct 2022].Suche in Google Scholar
24. Jee, J-G, Park, H-J, Haam, S-J, Lee, C-H. Effects of nonisobaric and isobaric steps on O2 pressure swing adsorption for an aerator. Ind Eng Chem Res 2002;41:4383–92. https://doi.org/10.1021/ie020088k.Suche in Google Scholar
25. Chou, CT, Huang, WC. Simulation of a four-bed pressure swing adsorption process for oxygen enrichment. Ind Eng Chem Res 1994;33:1250–8. https://doi.org/10.1021/ie00029a022.Suche in Google Scholar
26. Santos, JC, Portugal, AF, Magalhães, FD, Mendes, A. Optimization of medical PSA units for oxygen production. Ind Eng Chem Res 2006;45:1085–96. https://doi.org/10.1021/ie0504809.Suche in Google Scholar
27. Made-in-China.com. High carbon steel price. https://www.made-in-china.com/price/high-carbon-steel-price.html [Accessed 15 Sep 2025].Suche in Google Scholar
28. Made-in-China.com. Rubber conveyor belt price. https://www.made-in-china.com/products-search/hot-china-products/rubber_conveyor_belt_price.html [Accessed 15 Sep 2025].Suche in Google Scholar
29. Alibaba.com. Stainless steel 304 price per Kg. https://www.alibaba.com/showroom/stainless-steel-304-price-per-kg.html [Accessed 15 Sep 2025].Suche in Google Scholar
30. Peters, MS, Timmerhaus, KD, West, RE. Plant design and economics for chemical engineers, 5th ed. New York: McGraw-Hill; 2003.Suche in Google Scholar
31. Towler, GP, Sinnott, RK. Chemical engineering design: principles, practice and economics of plant and process design. Amsterdam: Elsevier/Butterworth-Heinemann; 2008.Suche in Google Scholar
32. Turton, R, editor. Analysis, synthesis, and design of chemical processes, 3rd ed. Upper Saddle River, NJ: Prentice Hall PTR; 2009.Suche in Google Scholar
33. Sircar, S, Golden, TC. Purification of hydrogen by pressure swing adsorption. Separ Sci Technol 2000;35:667–87. https://doi.org/10.1081/SS-100100183.Suche in Google Scholar
34. Benkirane, L, Metyouy, K, Chafik, T. Integration of large-scale pressure swing adsorption units in local hospitals in Morocco: design, simulation and performance evaluation. Sep Purif Technol 2024;333:125886. https://doi.org/10.1016/j.seppur.2023.125886.Suche in Google Scholar
35. PRISM® VSA oxygen generator – reliable On-Site gas supply.Suche in Google Scholar
36. Yang, RT. Air separation by pressure swing adsorption using superior adsorbents; FG26-98FT40115--02; 2001:789503. https://doi.org/10.2172/789503.Suche in Google Scholar
37. Yang, RT. Adsorbents: fundamentals and applications. Hoboken, NJ: Wiley-Interscience; 2003.10.1002/047144409XSuche in Google Scholar
38. Kaneko, K. Determination of pore size and pore size distribution: adsorbents and catalysts; department of chemistry. Faculty of Science, Chiba University. J Membr Sci 1994;96:59–89. https://doi.org/10.1016/0376-7388(94)00123-9.Suche in Google Scholar
39. The Chemical Engineering Plant Cost Index ®. Chem Eng. https://www.chemengonline.com/pci-home [Accessed 15 Sep 2025].Suche in Google Scholar
40. Smith, R. Chemical process design and integration, 2nd ed. Hoboken, NJ: Wiley; 2016. https://www.wiley.com/en-us/Chemical%2BProcess%2BDesign%2Band%2BIntegration%2C%2B2nd%2BEdition-p-9781119990147.Suche in Google Scholar
41. Enerdata. Morocco energy market report. https://www.enerdata.net/estore/country-profiles/morocco.html [Accessed 17 Sep 2025].Suche in Google Scholar
42. International Energy Agency (IEA). Energy prices – data product. https://www.iea.org/data-and-statistics/data-product/energy-prices [Accessed 15 Sep 2025].Suche in Google Scholar
43. Air Products. Cryogenic liquid containers Safetygram-27. https://www.airproducts.com/-/media/files/en/900/900-13-080-us-cryogenic-liquid-containers-safetygram-27.pdf [Accessed 15 Sep 2025].Suche in Google Scholar
44. Benkirane, L, Samid, A, Chafik, T. Small-scale medical oxygen production unit using PSA technology: modeling and sensitivity analysis. J Med Eng Technol 2023;47:321–35. https://doi.org/10.1080/03091902.2024.2331693.Suche in Google Scholar PubMed
45. Fu, Y, Liu, Y, Zhang, Q, Cao, X, Zhao, C. Study on PSA oxygen producing process under Plateau region: effect of purging flow rate on oxygen concentration and recovery. IOP Conf Ser Earth Environ Sci 2021;631:012083. https://doi.org/10.1088/1755-1315/631/1/012083.Suche in Google Scholar
46. Air Products. Cryogenic air separation plant. https://www.airproducts.com/supply-modes/cryogenic-air-separation-plant [Accessed 18 Sep 2025].Suche in Google Scholar
47. Ruthven, DM, Farooq, S. Air separation by pressure swing adsorption. Gas Sep Purif 1990;4:141–8. https://doi.org/10.1016/0950-4214(90)80016-E.Suche in Google Scholar
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