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FE65: Roles beyond amyloid precursor protein processing

  • Wan Ning Vanessa Chow , Hei Nga Maggie Cheung , Wen Li and Kwok-Fai Lau EMAIL logo
Published/Copyright: March 25, 2015
Become an author with De Gruyter Brill
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Cellular and Molecular Biology Letters
From the journal Cellular and Molecular Biology Letters Volume 20 Issue 1

Abstract

FE65 is a brain-enriched, developmentally regulated adaptor protein that was first identified as a binding partner of amyloid precursor protein (APP), an important molecule in Alzheimer’s disease. FE65 possesses three protein interaction domains, including an N-terminal WW domain and two C-terminal phosphotyrosine-binding (PTB) domains. It is capable of mediating the assembly of multimolecular complexes. Although initial work reveals its roles in APP processing and gene transactivation, increasing evidence suggests that FE65 participates in more diverse biological processes than originally anticipated. This article discusses the role of FE65 in signal transduction during cell stress and protein turnover through the ubiquitin-proteasome system and in various neuronal processes, including neurogenesis, neuronal migration and positioning, neurite outgrowth, synapse formation and synaptic plasticity, learning, and memory.

Keywords : FE65; Cell stress; Protein turnover; Neurogenesis; Neuronal migration and positioning; Neurite outgrowth; Synapse formation and synaptic plasticity; Learning and memory

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Received: 2014-10-10
Accepted: 2015-1-14
Published Online: 2015-3-25
Published in Print: 2015-3-1

© 2015 University of Wrocław, Poland

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  2. Evaluation of the potential of alkylresorcinols as superoxide anion scavengers and sox-regulon modulators using nitroblue tetrazolium and bioluminescent cell-based assays
  3. Cyclic phosphatidic acid induces G0/G1 arrest, inhibits AKT phosphorylation, and downregulates cyclin D1 expression in colorectal cancer cells
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https://doi.org/10.1515/cmble-2015-0002
Keywords for this article
FE65; Cell stress; Protein turnover; Neurogenesis; Neuronal migration and positioning; Neurite outgrowth; Synapse formation and synaptic plasticity; Learning and memory

Articles in the same Issue

  1. Identification of drought-induced transcription factors in Sorghum bicolor using GO term semantic similarity
  2. Evaluation of the potential of alkylresorcinols as superoxide anion scavengers and sox-regulon modulators using nitroblue tetrazolium and bioluminescent cell-based assays
  3. Cyclic phosphatidic acid induces G0/G1 arrest, inhibits AKT phosphorylation, and downregulates cyclin D1 expression in colorectal cancer cells
  4. Polymorphism of the APEX nuclease 1 gene in keratoconus and Fuchs endothelial corneal dystrophy
  5. FE65: Roles beyond amyloid precursor protein processing
  6. Single nucleotide polymorphisms in the STAT3 gene influence AITD susceptibility, thyroid autoantibody levels, and IL6 and IL17 secretion
  7. Antioxidant effect of a fermented powder of Lady Joy bean in primary rat hepatocytes
  8. Oncogene-dependent survival of highly transformed cancer cells under conditions of extreme centrifugal force – implications for studies on extracellular vesicles
  9. Changes in cell death of peripheral blood lymphocytes isolated from children with acute lymphoblastic leukemia upon stimulation with 7 Hz, 30 mT pulsed electromagnetic field
  10. Flow cytometric analysis of apoptosis in cryoconserved chicken primordial germ cells
  11. GGeneration of an efficient artificial promoter of bovine skeletal muscle alpha-actin gene (ACTA1) through addition of cis-acting element
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