Pharmaceutical Salts: Properties, Selection, and Use
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Pharmaceutical Salts: Properties, Selection, and Use
P. Heinrich Stahl and Camille G. Wermuth (editors)
ISBN: 978-3-90639-051-2
Hardcover, 388 pages, May 2011
The first edition of this handbook collated the scientific literature on this topic that had otherwise been rather limited and scattered throughout numerous journals and patents. The result was a comprehensive resource that addresses the preparation, selection, and use of pharmaceutically active salts, examining the opportunities for increased efficacy and improved drug delivery provided by the selection of an optimal salt. This second, revised edition is designed to meet the continued interest in both the topic and the book.
Altogether, the contributions to this book by an international team of authors from academia and the pharmaceutical industry reflect the multidisciplinary nature of the science involved in selection of suitable salt forms for new drug products. They present the necessary theoretical foundations as well as a wealth of detailed practical experience in the choice of pharmaceutically active salts, taking great care to address every conceivable aspect of the preparation of pharmaceutical salts.
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An introductory chapter presents a concise review of the various objectives in the pursuit of pharmaceutically active salts, followed by the theoretical background of salt formation. There then follow chapters on the practice of salt formation in an industrial R&D environment, as well as regulatory and patent issues. Practical examples for the practitioners at the lab bench are provided, before the book concludes with a comprehensive annotated compilation of the individual salt-forming acids and bases with their relevant properties, followed by an appendix containing tables with the acids and bases sorted alphabetically and by pKa, supplemented with other useful facts and data.
It is an essential reference for students of medicinal and pharmaceutical chemistry, and an indispensable handbook for R&D chemists, analytical chemists, biologists, development pharmacists, regulatory and patent specialists, and medicinal scientists engaged in preclinical development of drugs. In addition, this comprehensive and up-to-date guide is an instructive companion for all scientists involved in the research and development of drugs and, in particular, of pharmaceutical dosage forms.
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- Masthead
- From the Editor
- Contents
- Vice President’s Column
- Communicating Chemistry
- Distance Learning in Green Chemistry
- A Day to Remember
- Establishing a Vital Tradition. The Series of International Congresses of Applied Chemistry, 1894-1912
- Discovery of the Elements with Atomic Numbers 114 and 116
- IUPAC Announces Winners of the 2011 IUPAC Prizes for Young Chemists
- In Memoriam
- Election of IUPAC Officers and Bureau Members
- List of Keywords for Polymer Science Journals
- Advances in Immunochemistry and Applications to Human Health
- Update of “Glossary Terms Used in Computational Drug Design”
- Glossary of Small Molecules of Biological Interest
- Life-Cycle Assessment–Call for Partners
- The Periodic Table of the Isotopes: First Release
- Provisional Recommendations
- Glossary of Terms Used in Biomolecular Screening (IUPAC Recommendations 2011)
- IUPAC-IUGS Common Definition and Convention on the Use of the Year as a Derived Unit of Time (IUPAC Recommendations 2011)
- Chemical Speciation of Environmentally Significant Metals with Inorganic Ligands
- Mechanisms of Chemical Generation of Volatile Hydrides for Trace Element Determination (IUPAC Technical Report)
- IUPAC-NIST Solubility Data Series – recent Volumes
- Chemical Hazards in Food
- Pharmaceutical Salts: Properties, Selection, and Use
- Moscow Chemical Lyceum
- Materials Education
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- Nuclear Chemistry
- Chemistry and Sustainability
- Australasian Polymer
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- Mark Your Calendar
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