Advances in Immunochemistry and Applications to Human Health
Advances in Immunochemistry and Applications to Human Health
The field of immunochemistry is becoming increasingly important in the development of diagnostic and therapeutic approaches to many different diseases. The objective of this project is to compile present knowledge of the molecular basis of immunochemical interactions, to summarize the rapidly expanding applications in many health-related areas, and to critically discuss future research needs.
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The project builds on earlier work by the Chemistry and Human Health Division. A project on Immunochemistry of Metals (1999-047-1-700) has been completed, five publications* have dealt with the molecular mechanisms of immune sensitization caused by metals, and a critical evaluation of the use of clinical tests potentially available for diagnosing specific metal allergies. In addition, a project to develop a “Glossary of Terms in Immunotoxicology” (2007-053-1-700) is nearly completed.
The present project will further IUPAC’s involvement in immunochemistry by describing advances in the understanding of chemical interactions between antigens and T-cell receptors (TCR) or immunoglobulins, and depicting how immunochemical applications improve and diversify medical diagnostics and therapeutics. The project will cover the following:
1. Antibodies, antigens, and their interactions
—antibodies and TCR: Structure, hypervariable region, idiotype, paratope
—antigens: macromolecules, haptens, metals, small molecules. Domains, epitope (linear, conformational), epitope mapping, epitope tag, specific motifs
—interactions of antigens with antibody/TCR: antigenic determinants, complementarity-determining region, mimitopes, functional epitopes, effects of chemical modifications
—technical production: Polyclonal and monoclonal antibodies
2. Application in Diagnostics
—antibody labeling, ELISA and Spot-ELISA in diagnostics
—immunocytochemistry and histochemistry in pathology
—immunoseparation and immunoelectrophoresis in biochemistry
—biosensor detection systems in toxicology (drugs, toxicants, environmentally persistent chemicals, agents of chemical warfare)
3. Application in Therapeutics
—principles of biosimilarity and new biological entity
—design and production of therapeutic antibodies and of cell-specific carriers
—applications to autoimmune-disease, tumors, allergies
—active/passive vaccination in cancer
4. Design and Prediction of Chemical Affinities
—affinities and specificities of TCRs and anti-bodies
—epitope recognition patterns, protein-epitope mimetics, antibody libraries, engineered antibodies and fragments
—in silico prediction and computational chemistry of interactions used for design of therapeutic antibodies and for hazard characterization
The project is designed to facilitate the advancement of research in the chemical sciences and to serve the current educational needs of chemists and other scientists in the cross-disciplinary areas of chemistry, immunology, and human health.
*PAC76: 1255–1268 (2004), PAC76: 1269–1281 (2004), PAC78: 2155–2168 (2006), PAC80: 1349–364 (2008), and PAC81: 153–167 (2009).
For more information, contact Task Group Chair Michael Schwenk <mike.schwenk@gmx.net>.
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Articles in the same Issue
- Masthead
- From the Editor
- Contents
- Vice President’s Column
- Communicating Chemistry
- Distance Learning in Green Chemistry
- A Day to Remember
- Establishing a Vital Tradition. The Series of International Congresses of Applied Chemistry, 1894-1912
- Discovery of the Elements with Atomic Numbers 114 and 116
- IUPAC Announces Winners of the 2011 IUPAC Prizes for Young Chemists
- In Memoriam
- Election of IUPAC Officers and Bureau Members
- List of Keywords for Polymer Science Journals
- Advances in Immunochemistry and Applications to Human Health
- Update of “Glossary Terms Used in Computational Drug Design”
- Glossary of Small Molecules of Biological Interest
- Life-Cycle Assessment–Call for Partners
- The Periodic Table of the Isotopes: First Release
- Provisional Recommendations
- Glossary of Terms Used in Biomolecular Screening (IUPAC Recommendations 2011)
- IUPAC-IUGS Common Definition and Convention on the Use of the Year as a Derived Unit of Time (IUPAC Recommendations 2011)
- Chemical Speciation of Environmentally Significant Metals with Inorganic Ligands
- Mechanisms of Chemical Generation of Volatile Hydrides for Trace Element Determination (IUPAC Technical Report)
- IUPAC-NIST Solubility Data Series – recent Volumes
- Chemical Hazards in Food
- Pharmaceutical Salts: Properties, Selection, and Use
- Moscow Chemical Lyceum
- Materials Education
- Global Chemical Safety and Sustainability
- Nuclear Chemistry
- Chemistry and Sustainability
- Australasian Polymer
- Biological Inorganic Chemistry
- Philosophy of Chemistry
- Chemistry for Sustainable Agriculture
- Environmental Science
- Mycotoxins and Phycotoxins
- Mark Your Calendar
- World Forum for Advanced Materials
