Validation of Qualitative and Semi-Quantitative (Screening) Methods by Collaborative Trial
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Validation of Qualitative and Semi-Quantitative (Screening) Methods by Collaborative Trial
Guidelines for method validation need to provide information as to the required number of participating laboratories, characteristics of the test materials to be used in the study, and details on the statistical treatment of the results. It is important to make an objective assessment as to whether a method, once validated, is fit for analysis. Information on how this will be achieved should also be given in the guidelines.
Most quantitative analytical methods, when adopted and published as an international standard, are now required to be validated according to the international harmonized protocol: W. Horwitz, Protocol for the design, conduct, and interpretation of method performance studies [Pure and Applied Chemistry67, 331–343 (1995)] or the ISO 5725 series of standards. The Horwitz protocol is suitable only for quantitative methods. As there is a current, increasing demand and the availability of so called screening methods (qualitative or semi-quantitative), the existing protocol is not entirely suitable for interlaboratory validation of such methods. For example, many problems in food control are only being handled by qualitative or semiquantitative methods. For this reason, guidelines for the validation of screening methods, based on immunological or DNA-based technologies, are urgently needed. The aim of this project is to develop suitable guidelines for this purpose.
For more information and comments, contact the task group chairman, Elke Anklam <elke.anklam@cec.eu.int>.
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Artikel in diesem Heft
- Masthead
- From the Editor
- Contents
- Encouraging Involvement Among Chemists
- Looking in the Same Direction
- Frontier Science in the Middle East
- Communicating Science Information Clearly
- Can Ambiguous Terminology Cause a Barrier to Trade?
- What Is Butadiene?
- Alexandra Navrotsky Awarded the 2006 Rossini Lecture
- The Year of . . .
- Safety Training Program – Call for Applicants
- ACD/Labs’ Free Naming Software Service Generates 200 000 IUPAC Names via the Web
- Chmoogle Search Engine Integrates ChemSketch
- Chemical Education: Responsible Stewardship
- Young Ambassadors for Chemistry Krasnoyarsk, Russia, 14–18 November 2005
- Microstructure and Properties of Thermotropic Liquid-Crystalline Polymer Blends and Composites
- Validation of Qualitative and Semi-Quantitative (Screening) Methods by Collaborative Trial
- Calibration of Organic and Inorganic Oxygen-Bearing Isotopic Reference Materials
- IUPAC Seeks Your Comments
- Nonspecific Sensor Arrays (“electronic tongue”) for Chemical Analysis of Liquids (IUPAC Technical Report)
- Supramolecular Assemblies With DNA (Special Topic Article)
- Macromolecule-Metal Complexes
- Analytical Chemistry and Chemical Analysis
- Novel Materials and Synthesis
- Polymers for Africa
- Carotenoids
- Biocalorimetry 30 April – 4 May 2006, Rio de Janeiro, RJ, Brazil
- Macro and Supramolecular Architectures and Materials 28 May – 1 June 2006, Tokyo, Japan
- Advanced Polymeric Materials 11 June – 15 June 2006, Bratislava, Slovakia
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- Radical Polymerization 3 – 8 September 2006, Il Ciocco, Italy
- Inorganic Materials 23 – 26 September 2006, Ljubljana, Slovenia
- Conference Call
- Mark Your Calendar
