Analogue-Based Drug Discovery
Analogue-Based Drug Discovery
J. Fischer and R.C. Ganellin (editors)
Wiley-VCH, 2006 [ISBN 3-527-31257-9]
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Statistically, every second drug is an analogue, and their market value amounts to two-thirds of all drugs. Analogues are the most successful way of inventing a new drug and they provide the required improvements in drug therapy.
This is the first authoritative overview of past and current strategies for successful drug development by molecular modification of known leads. The book is a unique resource, which spans the important drug classes in most major therapeutic fields.
Analogue-based drug discovery is discussed among others, for beta blockers, ACE inhibitors, steroids, opiates, stigmines, proton pump inhibitors, platinum anti-cancer compounds, and anti-infective quinolones. Case studies, by the respective inventors of selected commercially successful drug analogues provide prime advice for new drug development projects based on analogue modification. The book includes a table of the most successful drug analogues as based on the IMS ranking and compares them in terms of chemical structure, mode of action, launch year, and patent priority.
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- From the Editor
- Contents
- Reflections at the End of a Presidency
- A Wrap-Up of the General Assembly
- Division Roundups
- Thanks to its Enduring Corrosion Resistance, an Indian Historical Artifact’s Appearance Belies its Age
- Where is there Wisdom to be Found in Ancient Materials Chemistry?
- IUPAC–Samsung Education Prize for 2005
- IUPAC-Richter Prize in Medicinal Chemistry
- Standard Atomic Weights Revised
- New CAs Join IUPAC
- IUPAC Poster Prizes Awarded in Denmark
- Fullerene Nomenclature–An Addendum to IUPAC History
- Emerging Issues in Developing Countries
- JCAMP-DX for Electron Magnetic Resonance
- XML-Based IUPAC Standard for Experimental, Predicted, and Critically Evaluated Thermodynamic Property Data Storage and Capture (ThermoML)
- Critical Evaluation of Stability Constants of Metal Complexes of Complexones for Biomedical and Environmental Applications (IUPAC Technical Report)
- Round Robin Test on the Molecular Characterization of Epoxy Resins by Liquid Chromatography
- Organic Synthesis–PAC Special Topic Issue
- Nomenclature of Inorganic Chemistry – IUPAC Recommendations 2005
- Analogue-Based Drug Discovery
- Measurement of the Thermodynamic Properties of Multiple Phases
- Polymer Chemistry, Reactions and Processes
- The Periodic Table: Into the 21st Century
- Nanotechnology: Science and Application
- Heterocyclic Conference
- Electrical and Related Properties of Organic Solids and Polymers
- Physical Chemistry: Education and Challenges
- Neurotoxic Metals: Lead, Manganese, and Mercury– From Research to Prevention
- Polymers and Organic Chemistry
- Biodiversity and Natural Products
- Green Chemistry
- Aromatic Compounds
- Organometallic Chemistry
- Biotechnology: Milestones towards Sustainability of Human Society
- Mark Your Calendar
- Index for 2005
Articles in the same Issue
- Masthead
- From the Editor
- Contents
- Reflections at the End of a Presidency
- A Wrap-Up of the General Assembly
- Division Roundups
- Thanks to its Enduring Corrosion Resistance, an Indian Historical Artifact’s Appearance Belies its Age
- Where is there Wisdom to be Found in Ancient Materials Chemistry?
- IUPAC–Samsung Education Prize for 2005
- IUPAC-Richter Prize in Medicinal Chemistry
- Standard Atomic Weights Revised
- New CAs Join IUPAC
- IUPAC Poster Prizes Awarded in Denmark
- Fullerene Nomenclature–An Addendum to IUPAC History
- Emerging Issues in Developing Countries
- JCAMP-DX for Electron Magnetic Resonance
- XML-Based IUPAC Standard for Experimental, Predicted, and Critically Evaluated Thermodynamic Property Data Storage and Capture (ThermoML)
- Critical Evaluation of Stability Constants of Metal Complexes of Complexones for Biomedical and Environmental Applications (IUPAC Technical Report)
- Round Robin Test on the Molecular Characterization of Epoxy Resins by Liquid Chromatography
- Organic Synthesis–PAC Special Topic Issue
- Nomenclature of Inorganic Chemistry – IUPAC Recommendations 2005
- Analogue-Based Drug Discovery
- Measurement of the Thermodynamic Properties of Multiple Phases
- Polymer Chemistry, Reactions and Processes
- The Periodic Table: Into the 21st Century
- Nanotechnology: Science and Application
- Heterocyclic Conference
- Electrical and Related Properties of Organic Solids and Polymers
- Physical Chemistry: Education and Challenges
- Neurotoxic Metals: Lead, Manganese, and Mercury– From Research to Prevention
- Polymers and Organic Chemistry
- Biodiversity and Natural Products
- Green Chemistry
- Aromatic Compounds
- Organometallic Chemistry
- Biotechnology: Milestones towards Sustainability of Human Society
- Mark Your Calendar
- Index for 2005
