Critical Evaluation of Stability Constants of Metal Complexes of Complexones for Biomedical and Environmental Applications (IUPAC Technical Report)
Critical Evaluation of Stability Constants of Metal Complexes of Complexones for Biomedical and Environmental Applications (IUPAC Technical Report)
Giorgio Anderegg, Françoise Arnaud-Neu, Rita Delgado, Judith Felcman, and Konstantin Popov
Pure and Applied Chemistry
Vol. 77, No. 8, pp. 1445-1495 (2005)
This study involves evaluation of all reported proton and metal ion binding constants for the remaining commonly used complexones, and the identification of recommended values for use in chemical speciation calculations. Within these objectives, a priority was given to compounds of strong medical and environmental importance and to those (IDA and MIDA) that represent complex-forming fragments and decomposition products of higher denticity complexones.
Within a broad variety of applications, complexones have in common the regulation of metal concentrations in widely differing systems. Complexones are used in detergents, textile and paper processing, photographic developing solutions, scale solubilization in processing tanks, electroplating, and as components of agricultural micro-fertilizers. Annual industrial output of EDTA and other complexones in the thousands of tons.
This paper presents critical evaluations of available experimental data, published between 1945–2000, on stability constants of proton (hydron) and metal complexes for seven complexones of particular biomedical and environmental interest: iminodiacetic acid [2,2’-azanediyldiacetic acid, IDA], (methylimino)diacetic acid [2,2’-(methylazanediyl)diacetic acid, MIDA]; 2,2’,2’’,2’’’-{[(carboxymethyl)azanediyl]bis[(ethane-1,2-diyl)nitrilo]}tetraacetic acid (DTPA), 3,6,9,12-tetrakis(carboxymethyl)-3,6,9,12-tetraazatetradecanedioic acid (TTHA); 2,2’,2’’-(1,4,7-triazonane-1,4,7-triyl)triacetic acid (NOTA); 2,2’,2’’,2’’’-(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetic acid (DOTA); 2,2’,2’’,2’’’-(1,4,8,11-tetraazacyclotetradecane-1,4,8,11-tetrayl)tetraacetic acid. Some typical errors in stability constant measurements for particular complexones are summarized. Higher quality data are selected and presented as “Recommended” or “Provisional.”
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Articles in the same Issue
- Masthead
- From the Editor
- Contents
- Reflections at the End of a Presidency
- A Wrap-Up of the General Assembly
- Division Roundups
- Thanks to its Enduring Corrosion Resistance, an Indian Historical Artifact’s Appearance Belies its Age
- Where is there Wisdom to be Found in Ancient Materials Chemistry?
- IUPAC–Samsung Education Prize for 2005
- IUPAC-Richter Prize in Medicinal Chemistry
- Standard Atomic Weights Revised
- New CAs Join IUPAC
- IUPAC Poster Prizes Awarded in Denmark
- Fullerene Nomenclature–An Addendum to IUPAC History
- Emerging Issues in Developing Countries
- JCAMP-DX for Electron Magnetic Resonance
- XML-Based IUPAC Standard for Experimental, Predicted, and Critically Evaluated Thermodynamic Property Data Storage and Capture (ThermoML)
- Critical Evaluation of Stability Constants of Metal Complexes of Complexones for Biomedical and Environmental Applications (IUPAC Technical Report)
- Round Robin Test on the Molecular Characterization of Epoxy Resins by Liquid Chromatography
- Organic Synthesis–PAC Special Topic Issue
- Nomenclature of Inorganic Chemistry – IUPAC Recommendations 2005
- Analogue-Based Drug Discovery
- Measurement of the Thermodynamic Properties of Multiple Phases
- Polymer Chemistry, Reactions and Processes
- The Periodic Table: Into the 21st Century
- Nanotechnology: Science and Application
- Heterocyclic Conference
- Electrical and Related Properties of Organic Solids and Polymers
- Physical Chemistry: Education and Challenges
- Neurotoxic Metals: Lead, Manganese, and Mercury– From Research to Prevention
- Polymers and Organic Chemistry
- Biodiversity and Natural Products
- Green Chemistry
- Aromatic Compounds
- Organometallic Chemistry
- Biotechnology: Milestones towards Sustainability of Human Society
- Mark Your Calendar
- Index for 2005
