Synthesis of ether-linked [60]fullerene glycoconjugates by nucleophilic cyclopropanation
-
Zsolt Fejes
and
Pál Herczegh
Abstract
Ethyl acetoacetate-sugar derivatives were prepared by standard alkylation of primary or secondary hydroxyls of diacetonide-protected sugars with ethyl 4-chloroacetoacetate. The obtained d-fructose, d-galactose, d-glucose and d-allose derivatives were conjugated to C60 using the Bingel reaction to afford hydrolytically stable, ether-linked fullerene-carbohydrates. Conjugation of an ester-protected mannose derivative to the C60 scaffold was carried out by the combination of the acetoacetate chemistry with the azide-alkyne click reaction.
References
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Articles in the same Issue
- Laser microsampling and multivariate methods in provenance studies of obsidian artefacts
- Ultra-trace arsenic and mercury speciation and determination in blood samples by ionic liquid-based dispersive liquid–liquid microextraction combined with flow injection-hydride generation/cold vapor atomic absorption spectroscopy
- Determination of formaldehyde by flow injection analysis with spectrophotometric detection exploiting brilliant green–sulphite reaction
- Passive sampling application to control air quality in interior of new vehicles
- Low-temperature enzymatic hydrolysis resolution in mini-emulsion media
- Performance and characterisation of CeO2–TiO2–WO3 catalysts for selective catalytic reduction of NO with NH3
- Catalytic wet peroxide oxidation of m-cresol over Fe/γ-Al2O3 and Fe–Ce/γ-Al2O3
- Morphology, structure, and photoactivity of two types of graphene oxide–TiO2 composites
- A novel efficient magnetic core–zeolitic shell nanocatalyst system: preparation, characterization and activity
- Characterisation and coagulation performance of polysilicate–ferric–zinc
- Antioxidant activity of rosemary extracts in solution and embedded in polymeric systems
- Comparison of selected aroma compounds in cultivars of sea buckthorn (Hippophae rhamnoides L.)
- Thio-click approach to the synthesis of stable glycomimetics
- Synthesis of ether-linked [60]fullerene glycoconjugates by nucleophilic cyclopropanation
