Contribution of SuPAR for patients in a situation of uncertainty downstream of emergencies
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Marina Brailova
und
Farès Moustafa
Abstract
Objectives
Evolution is difficult to predict for some patients at emergency department (ED). The soluble urokinase plasminogen activator receptor (suPAR) is a non-specific prognostic inflammatory blood biomarker with a high negative predictive value for pejorative outcomes. The aim of this study was to investigate the relationship between low levels of suPAR at ED admission and patient discharge following hospitalization in a short stay unit.
Methods
We carried out a single-center prospective observational study in the acute-care hospital ward of a university hospital center, including patients over 18 years old with an intermediate triage score.
Results
Overall, 202 acute medical patients were included, exhibiting a mean suPAR level of 7.43 ± 3.36 μg/L. Of these patients, 25 (12.4 %) displayed a suPAR dosage below 4 μg/L and 177 (87.6 %) a dosage ≥4 μg/L. At 24 h, 55 patients (27.2 %) were discharged, 139 (68.8 %) were hospitalized, and five (2.5 %) were either admitted to intensive care or died. In contrast to group with a high suPAR rate, those with suPAR <4 μg/L benefited from secure ED discharge (OR=5.68; CI 95 %=2.6–12.4). For predicting hospital discharge, patients with a suPAR value <4 μg/L had an AUC-ROC of 0.75. (95% CI 0.67–0.83).
Conclusions
Our study revealed that in patients with a high triage scale level and requiring a monitoring period, SuPAR levels under 4 μg/L could have enabled five times more patients to return home compared with those exhibiting a level ≥4 μg/L at emergency visit.
Funding source: Virogates
Award Identifier / Grant number: Generous gift of the reagents
Acknowledgments
We thank Virogates® laboratory for providing the analysis material for suPAR.
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Research ethics: The Ethics Committee of Sud-Méditerranée (number 221 C41) approved the study protocol on December 08, 2021. The study was conducted in accordance with the Declaration of Helsinki (rev. 2013).
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Informed consent: Patients were informed of their right to express their disagreement regarding the use of their clinical information for research purposes.
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Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Use of Large Language Models, AI and Machine Learning Tools: None declared.
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Conflict of interest: The authors state no conflict of interest.
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Research funding: Virogates® laboratory give funding for materials of suPAR laboratory analysis. Virogates® had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
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Data availability: All the data are available on request at the corresponding author.
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Clinical trial registration: NCT01390623.
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Supplementary Material
This article contains supplementary material (https://doi.org/10.1515/cclm-2025-1101).
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