Home Medicine Influence of patients’ clinical features at intensive care unit admission on performance of cell cycle arrest biomarkers in predicting acute kidney injury
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Influence of patients’ clinical features at intensive care unit admission on performance of cell cycle arrest biomarkers in predicting acute kidney injury

  • Bo Yang EMAIL logo , Yun Xie , Francesco Garzotto , Ghada Ankawi , Alberto Passannante , Alessandra Brendolan , Raffaele Bonato , Mariarosa Carta , Davide Giavarina , Enrico Vidal , Dario Gregori ORCID logo and Claudio Ronco ORCID logo
Published/Copyright: September 28, 2020
Clinical Chemistry and Laboratory Medicine (CCLM)
From the journal Clinical Chemistry and Laboratory Medicine (CCLM) Volume 59 Issue 2

Abstract

Objectives

Identification of acute kidney injury (AKI) can be challenging in patients with a variety of clinical features at intensive care unit (ICU) admission, and the capacity of biomarkers in this subpopulation has been poorly studied. In our study we examined the influence that patients’ clinical features at ICU admission have over the predicting ability of the combination of urinary tissue inhibitor of metalloproteinase-2 (TIMP2) and insulin-like growth factor binding protein 7 (IGFBP7).

Methods

Urinary [TIMP2]•[IGFBP7] were measured for all patients upon admission to ICU. We calculated the receiver operating characteristics (ROC) curves for AKI prediction in the overall cohort and for subgroups of patients according to etiology of ICU admission, which included: sepsis, trauma, neurological conditions, cardiovascular diseases, respiratory diseases, and non-classifiable causes.

Results

In the overall cohort of 719 patients, 239 (33.2%) developed AKI in the first seven days. [TIMP2]•[IGFBP7] at ICU admission were significantly higher in AKI patients than in non-AKI patients. This is true not only for the overall cohort but also in the other subgroups. The area under the ROC curve (AUC) for [TIMP2]•[IGFBP7] in predicting AKI in the first seven days was 0.633 (95% CI 0.588–0.678), for the overall cohort, with sensitivity and specificity of 66.1 and 51.9% respectively. When we considered patients with combined sepsis, trauma, and respiratory disease we found a higher AUC than patients without these conditions (0.711 vs. 0.575; p=0.002).

Conclusions

The accuracy of [TIMP2]•[IGFBP7] in predicting the risk of AKI in the first seven days after ICU admission has significant variability when the reason for ICU admission is considered.

Keywords: acute kidney injury; biomarkers; insulin-like growth factor binding protein 7 (IGFBP7); tissue inhibitor of metalloproteinase-2 (TIMP2)
Corresponding author: Bo Yang, Department of Nephrology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, PR China; and International Renal Research Institute of Vicenza, San Bortolo Hospital, Viale Rodolfi 37, 36100Vicenza, Italy, E-mail:

Acknowledgments

The authors are grateful to Gregorio Aramid Romero González, Alejandra Molano Trivino, Ana De Castro, and all the fellows of the International Renal Research Institute of Vicenza who helped in the study.

  1. Research funding: None declared.

  2. Author contributions: CR, BY, YX, FG and RB contributed to study design. BY, YX, GA and AP contributed to data collection. AB and FF contributed to patient enrollment. DG and MC contributed to laboratory work. FG, EV and GD contributed to statistical analysis. BY, GA, AP and CR contributed to manuscript writing and editing. All authors read and approved the final manuscript. All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: CR is a consultant for Astute Medical, Ortho, and Biomerieux. All the other authors declared no competing interests.

  4. Informed consent: Informed consent was obtained from all individuals included in this study.

  5. Ethical approval: The study was approved by the Institutional Ethics Committee of San Bortolo Hospital, Vicenza, Italy (Comitato Etico provinciale aULSS 8 Vicenza) (Exp. number: 03/17). The clinical investigation was conducted according to the principles expressed in the Declaration of Helsinki.

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Received: 2020-05-07
Accepted: 2020-09-11
Published Online: 2020-09-28
Published in Print: 2021-02-23

© 2020 Walter de Gruyter GmbH, Berlin/Boston

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  2. Editorial
  3. Assuring the quality of examinations using faecal immunochemical tests for haemoglobin (FIT)
  4. Review
  5. Capillary electrophoresis based on nucleic acid analysis for diagnosing inherited diseases
  6. Mini Reviews
  7. Negative hair test result after long-term drug use. About a case involving morphine and literature review
  8. Prorenin and active renin levels in paediatrics: a bioanalytical review
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  15. General Clinical Chemistry and Laboratory Medicine
  16. An evaluation of ten external quality assurance scheme (EQAS) materials for the faecal immunochemical test (FIT) for haemoglobin
  17. Optimizing hepcidin measurement with a proficiency test framework and standardization improvement
  18. Development of a certified reference material for anti-β2-glycoprotein I IgG – commutability studies
  19. Influence of patients’ clinical features at intensive care unit admission on performance of cell cycle arrest biomarkers in predicting acute kidney injury
  20. Efficacy of weekly administration of cholecalciferol on parathyroid hormone in stable kidney-transplanted patients with CKD stage 1–3
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  36. Letter to the Editors
  37. Harmonization of antineutrophil cytoplasmic antibodies (ANCA) testing by reporting test result-specific likelihood ratios: position paper
  38. Independent internal quality control (IQC) for faecal immunochemical tests (FIT) for haemoglobin: use of FIT manufacturers’ IQC for other FIT systems
  39. Parallel testing of 241 clinical nasopharyngeal swabs for the detection of SARS-CoV-2 virus on the Cepheid Xpert Xpress SARS-CoV-2 and the Roche cobas SARS-CoV-2 assays
  40. Sustained SARS-CoV-2 nucleocapsid antibody levels in nonsevere COVID-19: a population-based study
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  42. Complete blood counts and cell population data from Sysmex XN analyser in the detection of SARS-CoV-2 infection
  43. Macro creatine kinase in an asymptomatic patient: a case report
  44. Implementation of pre-labelled barcode tubes and the GeT-System in a general hospital for the exact documentation of the time of venous blood sample and improvement of sample quality
  45. Determination of free light chains: assay-dependent differences in interpretation
  46. Association between SOX17, Wif-1 and RASSF1A promoter methylation status and response to chemotherapy in patients with metastatic gastric cancer
  47. Effect of two organizational interventions on the frequency of haemoglobin A1c and erythrocyte sedimentation rate testing
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https://doi.org/10.1515/cclm-2020-0670
Keywords for this article
acute kidney injury; biomarkers; insulin-like growth factor binding protein 7 (IGFBP7); tissue inhibitor of metalloproteinase-2 (TIMP2)

Articles in the same Issue

  1. Frontmatter
  2. Editorial
  3. Assuring the quality of examinations using faecal immunochemical tests for haemoglobin (FIT)
  4. Review
  5. Capillary electrophoresis based on nucleic acid analysis for diagnosing inherited diseases
  6. Mini Reviews
  7. Negative hair test result after long-term drug use. About a case involving morphine and literature review
  8. Prorenin and active renin levels in paediatrics: a bioanalytical review
  9. Opinion Paper
  10. From therapeutic drug monitoring to total drug monitoring and drug-omics
  11. Perspectives
  12. The internal quality control in the traceability era
  13. Genetics and Molecular Diagnostics
  14. External quality assessment (EQA) and alternative assessment procedures (AAPs) in molecular diagnostics: findings of an international survey
  15. General Clinical Chemistry and Laboratory Medicine
  16. An evaluation of ten external quality assurance scheme (EQAS) materials for the faecal immunochemical test (FIT) for haemoglobin
  17. Optimizing hepcidin measurement with a proficiency test framework and standardization improvement
  18. Development of a certified reference material for anti-β2-glycoprotein I IgG – commutability studies
  19. Influence of patients’ clinical features at intensive care unit admission on performance of cell cycle arrest biomarkers in predicting acute kidney injury
  20. Efficacy of weekly administration of cholecalciferol on parathyroid hormone in stable kidney-transplanted patients with CKD stage 1–3
  21. Plasma metanephrines and prospective prediction of tumor location, size and mutation type in patients with pheochromocytoma and paraganglioma
  22. Emicizumab, the factor VIII mimetic bi-specific monoclonal antibody and its measurement in plasma
  23. Reference Values and Biological Variations
  24. Age appropriate reference intervals for eight kidney function and injury markers in infants, children and adolescents
  25. Cardiovascular Diseases
  26. Comparison of acetylsalicylic acid and clopidogrel non-responsiveness assessed by light transmittance aggregometry and PFA-100® in patients undergoing neuroendovascular procedures
  27. Trimethylamine-N-oxide (TMAO) predicts short- and long-term mortality and poor neurological outcome in out-of-hospital cardiac arrest patients
  28. Non-lactate strong ion difference and cardiovascular, cancer and all-cause mortality
  29. Infectious Diseases
  30. Performance of three automated SARS-CoV-2 antibody assays and relevance of orthogonal testing algorithms
  31. Development, evaluation, and validation of machine learning models for COVID-19 detection based on routine blood tests
  32. Searching for a role of procalcitonin determination in COVID-19: a study on a selected cohort of hospitalized patients
  33. Association of kidney function with effectiveness of procalcitonin-guided antibiotic treatment: a patient-level meta-analysis from randomized controlled trials
  34. Erratum
  35. Corrigendum to: The role of hyperhomocysteinemia as well as folate, vitamin B6 and B12 deficiencies in osteoporosis – a systematic review
  36. Letter to the Editors
  37. Harmonization of antineutrophil cytoplasmic antibodies (ANCA) testing by reporting test result-specific likelihood ratios: position paper
  38. Independent internal quality control (IQC) for faecal immunochemical tests (FIT) for haemoglobin: use of FIT manufacturers’ IQC for other FIT systems
  39. Parallel testing of 241 clinical nasopharyngeal swabs for the detection of SARS-CoV-2 virus on the Cepheid Xpert Xpress SARS-CoV-2 and the Roche cobas SARS-CoV-2 assays
  40. Sustained SARS-CoV-2 nucleocapsid antibody levels in nonsevere COVID-19: a population-based study
  41. Evidence for increased circulating procoagulant phospholipids in patients with COVID-19 pneumonia and their prognostic role
  42. Complete blood counts and cell population data from Sysmex XN analyser in the detection of SARS-CoV-2 infection
  43. Macro creatine kinase in an asymptomatic patient: a case report
  44. Implementation of pre-labelled barcode tubes and the GeT-System in a general hospital for the exact documentation of the time of venous blood sample and improvement of sample quality
  45. Determination of free light chains: assay-dependent differences in interpretation
  46. Association between SOX17, Wif-1 and RASSF1A promoter methylation status and response to chemotherapy in patients with metastatic gastric cancer
  47. Effect of two organizational interventions on the frequency of haemoglobin A1c and erythrocyte sedimentation rate testing
  48. Haemoglobin A1c determination from dried blood spots prepared with HemaSpot™ blood collection devices: comparison with fresh capillary blood
  49. Stability of catecholamines in whole blood: influence of time between collection and centrifugation
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