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Effects of calcium dobesilate (CaD) interference on serum creatinine measurements: a national External Quality Assessment (EQA)-based educational survey of drug-laboratory test interactions

  • Tianjiao Zhang , Xiuzhi Guo , Li’an Hou , Haijian Zhao , Rong Ma , Liangyu Xia ORCID logo , Honglei Li , Tingting You , Ling Qiu EMAIL logo and Chuanbao Zhang EMAIL logo
Published/Copyright: July 12, 2020
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Clinical Chemistry and Laboratory Medicine (CCLM)
From the journal Clinical Chemistry and Laboratory Medicine (CCLM) Volume 59 Issue 1

Abstract

Objectives

Drug-laboratory test interactions (DLTIs) are one of the major sources of laboratory errors. Calcium dobesilate (CaD) interference on serum creatinine testing is a widespread problem that has long been ignored in China. A national EQA-based survey was launched to investigate the current status of CaD interference on creatinine routine methods used in China and enhance the education of CaD interference in clinical laboratories.

Methods

A descriptive survey was developed to characterize the status quo of Chinese laboratory professionals’ cognition to CaD interference. Four of survey samples which were spiked with/without interference additive were shipped to 175 participant laboratories. The target reference values from a reference measurement procedure were compared against the results from participating laboratories to evaluate the CaD interference on serum creatinine measurements using enzymatic method or Jaffé method.

Results

The lack of knowledge of DLTIs and the barriers to collect information from pharmacological and laboratory data systems had become the main problems on implementing DLTIs education in China. A significant negative influence of CaD on enzymatic method was observed regardless of measurement platforms. Jaffé method was generally free from interaction with CaD but showed poor precision and accuracy at low creatinine concentrations.

Conclusions

More efforts should be made to enhance the education of DLTIs in clinical laboratories in China.

Keywords: calcium dobesilate; drug-laboratory test interactions; serum creatinine
Corresponding authors: Chuanbao Zhang, National Center for Clinical Laboratories, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, No. 1, Dahua Road, Dongdan, Dongcheng District, Beijing 100730, PR China, Phone: +86 10 58115059, E-mail: ; Ling Qiu, Department of Laboratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan, Dongcheng District, Beijing 100730, PR China, Phone: +86 10 69159707, E-mail:
Tianjiao Zhang and Xiuzhi Guo contributed equally to this work.

Funding source: China Capital Health Research and Development of Special Project

Award Identifier / Grant number: 2016-2-4017

  1. Research funding: This study was financially supported by the China Capital Health Research and Development of Special Project (2016-2-4017).

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Ethical approval: Anonymized left-over sera were collected from patients receiving physical examinations or hospitalized at Peking Union Medical College Hospital (PUMCH, Beijing, China). The study was reviewed and approved by the Ethics Committee of PUMCH.

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Supplementary Material

The online version of this article offers supplementary material (https://doi.org/10.1515/cclm-2020-0424).

Received: 2020-04-02
Accepted: 2020-06-21
Published Online: 2020-07-12
Published in Print: 2021-01-26

© 2020 Walter de Gruyter GmbH, Berlin/Boston

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https://doi.org/10.1515/cclm-2020-0424
Keywords for this article
calcium dobesilate; drug-laboratory test interactions; serum creatinine

Articles in the same Issue

  1. 10.1515/cclm-2020-frontmatter1
  2. Mario Plebani turns 70
  3. Editorial
  4. Measurement uncertainty and the importance of correlation
  5. Reviews
  6. Untangling the association between prostate-specific antigen and diabetes: a systematic review and meta-analysis
  7. The emerging role of cell senescence in atherosclerosis
  8. Mini Review
  9. Minimum retesting intervals in practice: 10 years experience
  10. Opinion Paper
  11. Cardiotoxic effects and myocardial injury: the search for a more precise definition of drug cardiotoxicity
  12. EFLM Papers
  13. The CRESS checklist for reporting stability studies: on behalf of the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) Working Group for the Preanalytical Phase (WG-PRE)
  14. Thoughts and expectations of young professionals about the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)
  15. Guidelines and Recommendations
  16. Evidence on clinical relevance of cardiovascular risk evaluation in the general population using cardio-specific biomarkers
  17. Genetics and Molecular Diagnostics
  18. A systematic evaluation of stool DNA preparation protocols for colorectal cancer screening via analysis of DNA methylation biomarkers
  19. General Clinical Chemistry and Laboratory Medicine
  20. The new IVD Regulation 2017/746: a case study at a large university hospital laboratory in Belgium demonstrates the need for clarification on the degrees of freedom laboratories have to use lab-developed tests to improve patient care
  21. Evaluation of serum electrolytes measurement through the 6-year trueness verification program in China
  22. Feasibility for aggregation of commutable external quality assessment results to evaluate metrological traceability and agreement among results
  23. Sample size and rejection limits for detecting reagent lot variability: analysis of the applicability of the Clinical and Laboratory Standards Institute (CLSI) EP26-A protocol to real-world clinical chemistry data
  24. Effects of calcium dobesilate (CaD) interference on serum creatinine measurements: a national External Quality Assessment (EQA)-based educational survey of drug-laboratory test interactions
  25. Mass spectrometric sample identification with indicator compounds introduced via labeled sample tubes
  26. Automation and validation of a MALDI-TOF MS (Mass-Fix) replacement of immunofixation electrophoresis in the clinical lab
  27. A new strategy implementing mass spectrometry in the diagnosis of congenital disorders of N-glycosylation (CDG)
  28. Analytical evaluation of four faecal immunochemistry tests for haemoglobin
  29. Reference Values and Biological Variations
  30. Study of total error specifications of lymphocyte subsets enumeration using China National EQAS data and Biological Variation Data Critical Appraisal Checklist (BIVAC)-compliant publications
  31. Mass spectrometric quantification of urinary 6-sulfatoxymelatonin: age-dependent excretion and biological variation
  32. Establishment of international autoantibody reference standards for the detection of autoantibodies directed against PML bodies, GW bodies, and NuMA protein
  33. Hematology and Coagulation
  34. Appropriate thresholds for accurate screening for β-thalassemias in the newborn period: results from a French center for newborn screening
  35. Cardiovascular Diseases
  36. Analysis of B-type natriuretic peptide impurities using label-free data-independent acquisition mass spectrometry technology
  37. Diabetes
  38. Hemoglobin variants in southern China: results obtained during the measurement of glycated hemoglobin in a large population
  39. Potential of MALDI-TOF mass spectrometry to overcome the interference of hemoglobin variants on HbA1c measurement
  40. Acknowledgment
  41. Acknowledgment
  42. Letter to the Editors
  43. Measurement uncertainty estimation for derived biological quantities
  44. Non-reproducible cardiac troponin results occurring with a particular reagent lot
  45. Successfully meeting analytical expectations for the fast 0/1-h algorithm for NSTEMI by internal control procedures for cardiac troponin T
  46. Performance of perpendicular drop versus tangent skimming gating of M-protein in proficiency testing challenges
  47. Analytical evaluation of Reebio procalcitonin latex-enhanced immunoturbidimetric assay on the HITACHI Labospect 008AS
  48. Assessment of intraindividual agreement in prolactin results after post-polyethylene glycol precipitation test for the estimation of macroprolactin. Should the precipitation procedure be repeated in the same patient?
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