CCLM Award for the Most Cited Paper Recently Published
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Mario Plebani
The CCLM Award for the Most Cited Paper Recently Published was initiated in 2008, and since 2014 the prize has been awarded at the EFLM-UEMS Conferences. Clinical Chemistry and Laboratory Medicine (CCLM) is the official journal of the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM). The award honors the most cited original article published in the last 2years and rewards the authors of articles that generate high interest among the journal’s readership.
This year’s award winning manuscript is the Routine use of the Ion Torrent AmpliSeq™ Cancer Hotspot Panel for identification of clinically actionable somatic mutations (Clin Chem Lab Med 2014;52:707–14), by Gregory J. Tsongalis, Jason D. Peterson, Francine B. de Abreu, Christopher D. Tunkey, Torrey L. Gallagher, Linda D. Strausbaugh, Wendy A. Wells and Christopher I. Amos. This was one of the first published papers to highlight analytical validation processes for next generation sequencing (NGS) of a cancer hotspot panel. As somatic mutation analysis in human cancer was becoming critical in the selection of appropriate therapies for patient management, the Dartmouth group implemented NGS for a 50 gene cancer hotspot panel and established a validation protocol to assess performance characteristics of these highly complex assays. They showed that by monitoring traditional performance metrics, NGS assays could be routinely used in a clinical laboratory setting.
This year’s award was presented during the Opening Ceremony of the 4th EFLM-UEMS Congress 2016 “Laboratory Medicine at the Clinical Interface” in Warsaw (September 21–24, 2016). Dr. Tsongalis and his colleagues will get a 1-year free online subscription to CCLM, and Dr. Tsongalis – as the first author – receives an award certificate and a monetary prize.
Mario Plebani
Editor-in-Chief
Clinical Chemistry and Laboratory Medicine
Gregory J. Tsongalis
Professor of Pathology
©2016 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Editorials
- CCLM Award for the Most Cited Paper Recently Published
- Laboratory economics. Risk or opportunity?
- Reviews
- Molecular diagnosis and precision medicine in allergy management
- The insulin autoimmune syndrome (IAS) as a cause of hypoglycaemia: an update on the pathophysiology, biochemical investigations and diagnosis
- Opinion Paper
- Role of microsatellite instability, immunohistochemistry and mismatch repair germline aberrations in immunosuppressed transplant patients: a phenocopy dilemma in Muir-Torre syndrome
- Genetics and Molecular Diagnostics
- Time and tumor type (primary or metastatic) do not influence the detection of BRAF/NRAS mutations in formalin fixed paraffin embedded samples from melanomas
- False low holotranscobalamin levels in a patient with a novel TCN2 mutation
- General Clinical Chemistry and Laboratory Medicine
- Quality performance of laboratory testing in pharmacies: a collaborative evaluation
- Cost evaluation of clinical laboratory in Taiwan’s National Health System by using activity-based costing
- Impact of sample processing on the measurement of circulating microparticles: storage and centrifugation parameters
- HbA1c: EQA in Germany, Belgium and the Netherlands using fresh whole blood samples with target values assigned with the IFCC reference system
- Iohexol clearance in unstable critically ill patients: a tool to assess glomerular filtration rate
- Characteristics of Chinese patients with antiphospholipid syndrome and the ability of lupus anticoagulant assays to identify them
- Reference Values and Biological Variations
- Distribution of soluble suppression of tumorigenicity 2 (sST2), N-terminal pro-brain natriuretic peptide (NT-proBNP), high sensitive troponin I and high-sensitive troponin T in umbilical cord blood
- Hematology and Coagulation
- Evaluation of Mindray BC-6800 body fluid mode for automated cerebrospinal fluid cell counting
- Cancer Diagnostics
- Increased sialylation and reduced fucosylation of exfoliated cervical cells are potential markers of carcinogenesis in the cervix
- Cardiovascular Diseases
- High incidence of macrotroponin I with a high-sensitivity troponin I assay
- Infectious Diseases
- Prospective evaluation of biomarkers for prediction of quality of life in community-acquired pneumonia
- Letter to the Editor
- The use of extra-analytical phase quality indicators by clinical laboratories: the results of an international survey
- Quality of reporting of diagnostic test accuracy studies in medical laboratory journals
- Impact of under-filled blood collection tubes containing K2EDTA and K3EDTA as anticoagulants on automated complete blood count (CBC) testing
- Stability of plasma albumin depends on measurement method
- Evaluation of screening method for Bence Jones protein analysis
- Reference intervals for the Kryptor second-generation chromogranin A assay
- Evaluation of an automated urinary iodine measurement using AU5800 analyzer with AutoLab Iodine reagent
- Evaluation of the accuracy of complete blood count for insufficient blood samples
- The use of a “gray zone” considering measurement uncertainty in pharmacological tests. The serum growth hormone stimulation test as an example
- Keeping Ebola out of the lab: a practical solution on how to analyze Ebola associated blood anomalies
- Standardized fixation process is crucial to permit molecular analyses in formalin-fixed and paraffin-embedded melanoma samples
- Congress Abstracts
- 48th National Congress of the Italian Society of Clinical Biochemistry and Clinical Molecular Biology (SIBioC – Laboratory Medicine)
- 8th Santorini Conference Systems Medicine and Personalised Health and Therapy
- Congress of Laboratory Medicine and Clinical Chemistry
Articles in the same Issue
- Frontmatter
- Editorials
- CCLM Award for the Most Cited Paper Recently Published
- Laboratory economics. Risk or opportunity?
- Reviews
- Molecular diagnosis and precision medicine in allergy management
- The insulin autoimmune syndrome (IAS) as a cause of hypoglycaemia: an update on the pathophysiology, biochemical investigations and diagnosis
- Opinion Paper
- Role of microsatellite instability, immunohistochemistry and mismatch repair germline aberrations in immunosuppressed transplant patients: a phenocopy dilemma in Muir-Torre syndrome
- Genetics and Molecular Diagnostics
- Time and tumor type (primary or metastatic) do not influence the detection of BRAF/NRAS mutations in formalin fixed paraffin embedded samples from melanomas
- False low holotranscobalamin levels in a patient with a novel TCN2 mutation
- General Clinical Chemistry and Laboratory Medicine
- Quality performance of laboratory testing in pharmacies: a collaborative evaluation
- Cost evaluation of clinical laboratory in Taiwan’s National Health System by using activity-based costing
- Impact of sample processing on the measurement of circulating microparticles: storage and centrifugation parameters
- HbA1c: EQA in Germany, Belgium and the Netherlands using fresh whole blood samples with target values assigned with the IFCC reference system
- Iohexol clearance in unstable critically ill patients: a tool to assess glomerular filtration rate
- Characteristics of Chinese patients with antiphospholipid syndrome and the ability of lupus anticoagulant assays to identify them
- Reference Values and Biological Variations
- Distribution of soluble suppression of tumorigenicity 2 (sST2), N-terminal pro-brain natriuretic peptide (NT-proBNP), high sensitive troponin I and high-sensitive troponin T in umbilical cord blood
- Hematology and Coagulation
- Evaluation of Mindray BC-6800 body fluid mode for automated cerebrospinal fluid cell counting
- Cancer Diagnostics
- Increased sialylation and reduced fucosylation of exfoliated cervical cells are potential markers of carcinogenesis in the cervix
- Cardiovascular Diseases
- High incidence of macrotroponin I with a high-sensitivity troponin I assay
- Infectious Diseases
- Prospective evaluation of biomarkers for prediction of quality of life in community-acquired pneumonia
- Letter to the Editor
- The use of extra-analytical phase quality indicators by clinical laboratories: the results of an international survey
- Quality of reporting of diagnostic test accuracy studies in medical laboratory journals
- Impact of under-filled blood collection tubes containing K2EDTA and K3EDTA as anticoagulants on automated complete blood count (CBC) testing
- Stability of plasma albumin depends on measurement method
- Evaluation of screening method for Bence Jones protein analysis
- Reference intervals for the Kryptor second-generation chromogranin A assay
- Evaluation of an automated urinary iodine measurement using AU5800 analyzer with AutoLab Iodine reagent
- Evaluation of the accuracy of complete blood count for insufficient blood samples
- The use of a “gray zone” considering measurement uncertainty in pharmacological tests. The serum growth hormone stimulation test as an example
- Keeping Ebola out of the lab: a practical solution on how to analyze Ebola associated blood anomalies
- Standardized fixation process is crucial to permit molecular analyses in formalin-fixed and paraffin-embedded melanoma samples
- Congress Abstracts
- 48th National Congress of the Italian Society of Clinical Biochemistry and Clinical Molecular Biology (SIBioC – Laboratory Medicine)
- 8th Santorini Conference Systems Medicine and Personalised Health and Therapy
- Congress of Laboratory Medicine and Clinical Chemistry
