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Interconversion of stone composition profiles from two recurrent stone episodes in stone formers

  • Guohua Zeng EMAIL logo , Zhijian Zhao , Wenqi Wu , Lili Ou , Yeping Liang and Jian Yuan
Published/Copyright: March 14, 2014
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Clinical Chemistry and Laboratory Medicine (CCLM)
From the journal Clinical Chemistry and Laboratory Medicine (CCLM) Volume 52 Issue 7

Abstract

Background: The aim of the study was to investigate the interconversion of the stone chemical composition of two recurrent stone episodes in stone formers.

Methods: The data of 1098 stones analyses from 549 patients with a history of two renal stone episodes were selected and reviewed. The stone composition between the two recurrent episodes of stones was compared.

Results: The percent occurrences of stones caused by infection, known as infection stones, in new episodes of stones significantly increased by 7% and uric acid stones increased by 3.8% while the calcium oxalate stones decreased by 13.1% (each p<0.05). The mean recurrent interval of new episodes of stones was 34.2 months. Infection stones had a significant shorter interval time compared to calcium oxalate stones (p<0.001). On a patient-by-patient investigation, 32.9% of patients underwent conversions of stone compositions, with 31.9% and 34.1% in men and female, respectively (p=0.590). The mutual conversion of infection stones to calcium oxalate stones was most common. The 61.1% of patients with uric acid recurrent stones were composed of calcium oxalate in the previous episode of stones, and 5% and 51.7% of patients with infection stones developed stones of uric acid or calcium oxalate in the new episode, respectively.

Conclusions: Alterations of stone components during follow-up were found in as high as 32.9% of patients with no gender difference. The impetus of these shifts is not readily apparent. Accurate and repeated stone analyses throughout the course of recurrent stone disease are highly warranted, which may be useful to prevent recurrence of composition-specific stones.

Keywords: interconversion; kidney stones; recurrence; stone composition
Corresponding author: Guohua Zeng, Department of Urology, Minimally Invasive Surgery Center, The First Affiliated Hospital of Guangzhou Medical University, and Guangdong Key Laboratory of Urology, 1# Kangda Road, Haizhu District, Guangzhou 510230, P.R. China, E-mail:
aGuohua Zeng and Zhijian Zhao have contributed equally to this work.

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Received: 2013-10-15
Accepted: 2014-2-17
Published Online: 2014-3-14
Published in Print: 2014-7-1

©2014 by Walter de Gruyter Berlin/Boston

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https://doi.org/10.1515/cclm-2013-0886
Keywords for this article
interconversion; kidney stones; recurrence; stone composition

Articles in the same Issue

  1. Frontmatter
  2. Editorial
  3. Diagnosis of diabetes mellitus: reiterated responsibilities for the clinical laboratory
  4. Review
  5. The association between plasminogen activator inhibitor type 1 (PAI-1) levels, PAI-1 4G/5G polymorphism, and myocardial infarction: a Mendelian randomization meta-analysis
  6. Opinion Papers
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  9. General Clinical Chemistry and Laboratory Medicine
  10. A statistical basis for harmonization of thyroid stimulating hormone immunoassays using a robust factor analysis model
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  12. Combined light chain immunofixation to detect monoclonal gammopathy: a comparison to standard electrophoresis in serum and urine
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  14. Peripheral blood lymphocytes from patients with bipolar disorder demonstrate apoptosis and differential regulation of advanced glycation end products and S100B
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