Startseite S100B blood level measurement to exclude cerebral lesions after minor head injury: the multicenter STIC-S100 French study
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S100B blood level measurement to exclude cerebral lesions after minor head injury: the multicenter STIC-S100 French study

  • Said Laribi , Jamal Kansao , Didier Borderie , Corinne Collet , Patrick Deschamps , Redha Ababsa , Léonard Mouniam , Laurence Got , Alain Leon , Henri Thoannes , Aline Santin , Jean-Claude Kouyoumdjian , Claire Dahyot-Fizelier , Catherine Millet , Jean-Louis Golmard , Jean-Louis Beaudeux EMAIL logo und on behalf of the Stic-S100 Study Groupa
Veröffentlicht/Copyright: 13. November 2013
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Clinical Chemistry and Laboratory Medicine
Aus der Zeitschrift Clinical Chemistry and Laboratory Medicine Band 52 Heft 4

Abstract

Background: S100B protein measurement in blood is proposed to exclude the presence of computed tomography (CT) lesions after minor head injury (MHI). We aimed to validate S100B as an accurate and valuable screening tool for MHI diagnosis in a large multicenter study, as well as: 1) to evaluate whether a second S100B blood level determination 3 h after the first one would be informative; 2) to compare the bioclinical performances of the two commercially available automated methods of measurement of S100B for the screening of patients.

Methods: Four thousand and thirty MHI subjects were enrolled in a prospective observational multicenter study; results for serum S100B measurement determined within 3 h after the clinical event (H0) then at H3 were compared to that of cranial CT scans performed with 6 h following the presentation to emergency department. Both the Diasorin and the Roche Diagnostics assays were systematically performed.

Results: Cerebral lesions on CT scan were identified with sensitivity and negative-predictive value (NPV) of 96.3% and 99.4% (Diasorin, 1 dissonant case), and of 100% and 100% (Roche Diagnostics, no dissonant case). Sensitivity and NPV at H3 appeared lower than those at H0, due to the rapid decrease in S100B levels.

Conclusions: Serum S100B level on admission of patients with MHI is an accurate and useful screening tool to exclude intracranial lesions. Performing a second late S100B level determination is not informative. The two automated immunoassays appear usable in a similar manner, although the two methods are not interchangeable.

Keywords: biomarker; cranial computed tomography; liquid-phase immunoassay; minor head injury; S100B protein
Corresponding author: Jean-Louis Beaudeux, Clinical Chemistry Department, APHP, 149, rue de Sèvres, 75015 Paris, France, Phone: +33 1 44495111, E-mail:
aThe Study Group also included: N. Ouled, O. Walha-Chakroun, C. Welsch, C. Durand, P. Plaisance (Emergency Department, Lariboisière Hospital, Paris), M.-P. Coulhon (Clinical Biology Department, Pontoise Hospital).

Acknowledgments

This study was supported and funded by the STIC program of The French Ministry of Public Health, Paris, France, in favor of DRCD (Département de la Recherche Clinique et du Dévelopement) APHP-Ile-de France, France.

Conflict of interest statement

Authors’ conflict of interest disclosure: The authors stated that there are no conflicts of interest regarding the publication of this article. Research funding played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

Research funding: None declared.

Employment or leadership: None declared.

Honorarium: J.-L. Beaudeux punctually receives fees for consulting from Roche Diagnostics.

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Received: 2013-8-4
Accepted: 2013-10-7
Published Online: 2013-11-13
Published in Print: 2014-04-01

©2014 by Walter de Gruyter Berlin/Boston

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https://doi.org/10.1515/cclm-2013-0621
Schlagwörter für diesen Artikel
biomarker; cranial computed tomography; liquid-phase immunoassay; minor head injury; S100B protein

Artikel in diesem Heft

  1. Masthead
  2. Masthead
  3. Editorials
  4. Inflammatory bowel diseases: where we are and where we should go
  5. Thrombophilia testing. Useful or hype?
  6. Reviews
  7. Inflammatory bowel diseases: from pathogenesis to laboratory testing
  8. Crohn’s disease specific pancreatic antibodies: clinical and pathophysiological challenges
  9. Point/Counterpoint
  10. The utility of thrombophilia testing
  11. The futility of thrombophilia testing
  12. Genetics and Molecular Diagnostics
  13. Identification of an 18 bp deletion in the TWIST1 gene by CO-amplification at lower denaturation temperature-PCR (COLD-PCR) for non-invasive prenatal diagnosis of craniosynostosis: first case report
  14. General Clinical Chemistry and Laboratory Medicine
  15. Agreement of seven 25-hydroxy vitamin D3 immunoassays and three high performance liquid chromatography methods with liquid chromatography tandem mass spectrometry
  16. First trimester pregnancy-associated plasma protein A and human chorionic gonadotropin-beta in early and late pre-eclampsia
  17. S100B blood level measurement to exclude cerebral lesions after minor head injury: the multicenter STIC-S100 French study
  18. NGAL, L-FABP, and KIM-1 in comparison to established markers of renal dysfunction
  19. Value-added reporting of antinuclear antibody testing by automated indirect immunofluorescence analysis
  20. Cardiovascular Diseases
  21. A fit-for-purpose approach to analytical sensitivity applied to a cardiac troponin assay: time to escape the ‘highly-sensitive’ trap
  22. Diabetes
  23. A simple and precise method for direct measurement of fractional esterification rate of high density lipoprotein cholesterol by high performance liquid chromatography
  24. Infectious Diseases
  25. Detection of unamplified HCV RNA in serum using a novel two metallic nanoparticle platform
  26. Increased plasma arginase activity in human sepsis: association with increased circulating neutrophils
  27. Corrigendum
  28. The relationship between estimated average glucose and fasting plasma glucose
  29. Letter to the Editors
  30. The obsessive-compulsory clinical pathologist
  31. Prism effect of specimen receiving – generation of fundamentals for the smooth progress of analytical processing
  32. Preanalytical errors: the professionals’ perspective
  33. Corrected reports in laboratory medicine in a Chinese university hospital for 3 years
  34. Comparison of an enzymatic assay with liquid chromatography-pulsed amperometric detection for the determination of lactulose and mannitol in urine of healthy subjects and patients with active celiac disease
  35. Effect of freezing-thawing process on neuron specific enolase concentration in severe traumatic brain injury sera samples
  36. Undetected creatinine levels
  37. The effect of centrifugation on three urine protein assays: benzethonium chloride, benzalkonium chloride and pyrogallol red
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