Antibacterial compound from the endophytic fungus Phomopsis longicolla isolated from the tropical red seaweed Bostrychia radicans
-
Cíntia Erbert
,
Adriana A. Lopes
Abstract
Endophytic fungi isolated from the red seaweed Bostrychia radicans were studied to identify their molecularly diverse and biologically active natural chemical products. According to 28S ribosomal DNA-based identification, the strain named C81 was 98% identical to Phomopsis longicolla. This strain was cultivated in solid rice medium and produced three major metabolites identified as 18-deoxycytochalasin H (1), mycophenolic acid (2), and dicerandrol C (3). The chemical structures of these compounds were elucidated by 1D and 2D nuclear magnetic resonance as well as by mass spectrometry. Dicerandrol C had significant antimicrobial activity against Staphylococcus aureus (ATCC 6538) and Staphylococcus saprophyticus (ATCC 15305), with minimum inhibitory concentrations of 1 and 2 μg ml-1(1.33 and 2.66 μm), respectively. These results show the presence of promising metabolites and indicate that these natural products should be considered in the development of new antibiotics.
©2012 by Walter de Gruyter Berlin Boston
Articles in the same Issue
- Masthead
- Masthead
- Research Articles
- Polysiphonia sensu lato (Ceramiales, Florideophyceae) species of Caribbean Panama including Polysiphonia lobophoralis sp. nov. and Polysiphonia nuda sp. nov.
- Molecular support for the establishment of the new genus Laurenciella within the Laurencia complex (Ceramiales, Rhodophyta)
- Neosiphonia peruviensis sp. nov. (Rhodomelaceae, Rhodophyta) from the Pacific coast of South America
- Colpomenia durvillei (Scytosiphonaceae, Phaeophyceae): its distribution and relationships with other elongate species of the genus
- Phymatolithon lamii (Hapalidiaceae, Corallinales, Rhodophyta): a first report for the Mediterranean Sea
- Floristic macroalgal diversity in selected submarine caves located within two marine protected areas off Lampedusa Island and Sicily (Italy)
- Species composition, zonation, and biomass of marine benthic macroalgae in Kongsfjorden, Svalbard
- Diversity, occurrence, and habitats of the diatom genus Bacteriastrum (Bacillariophyta) in the northern Adriatic Sea, with the description of B. jadranum sp. nov.
- Characterization of the protein phosphatase 2c gene from Porphyra yezoensis and functional analysis under dessicating conditionsa
- Antibacterial compound from the endophytic fungus Phomopsis longicolla isolated from the tropical red seaweed Bostrychia radicans
- Short Communication
- First record of fertile gametophytes of Polysiphonia perforans (Ceramiales, Rhodophyta)
Articles in the same Issue
- Masthead
- Masthead
- Research Articles
- Polysiphonia sensu lato (Ceramiales, Florideophyceae) species of Caribbean Panama including Polysiphonia lobophoralis sp. nov. and Polysiphonia nuda sp. nov.
- Molecular support for the establishment of the new genus Laurenciella within the Laurencia complex (Ceramiales, Rhodophyta)
- Neosiphonia peruviensis sp. nov. (Rhodomelaceae, Rhodophyta) from the Pacific coast of South America
- Colpomenia durvillei (Scytosiphonaceae, Phaeophyceae): its distribution and relationships with other elongate species of the genus
- Phymatolithon lamii (Hapalidiaceae, Corallinales, Rhodophyta): a first report for the Mediterranean Sea
- Floristic macroalgal diversity in selected submarine caves located within two marine protected areas off Lampedusa Island and Sicily (Italy)
- Species composition, zonation, and biomass of marine benthic macroalgae in Kongsfjorden, Svalbard
- Diversity, occurrence, and habitats of the diatom genus Bacteriastrum (Bacillariophyta) in the northern Adriatic Sea, with the description of B. jadranum sp. nov.
- Characterization of the protein phosphatase 2c gene from Porphyra yezoensis and functional analysis under dessicating conditionsa
- Antibacterial compound from the endophytic fungus Phomopsis longicolla isolated from the tropical red seaweed Bostrychia radicans
- Short Communication
- First record of fertile gametophytes of Polysiphonia perforans (Ceramiales, Rhodophyta)
