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Vein segmentation and visualization of upper and lower extremities using convolution neural network

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Veröffentlicht/Copyright: 24. April 2024

Abstract

Objectives

The study focused on developing a reliable real-time venous localization, identification, and visualization framework based upon deep learning (DL) self-parametrized Convolution Neural Network (CNN) algorithm for segmentation of the venous map for both lower and upper limb dataset acquired under unconstrained conditions using near-infrared (NIR) imaging setup, specifically to assist vascular surgeons during venipuncture, vascular surgeries, or Chronic Venous Disease (CVD) treatments.

Methods

A portable image acquisition setup has been designed to collect venous data (upper and lower extremities) from 72 subjects. A manually annotated image dataset was used to train and compare the performance of existing well-known CNN-based architectures such as ResNet and VGGNet with self-parameterized U-Net, improving automated vein segmentation and visualization.

Results

Experimental results indicated that self-parameterized U-Net performs better at segmenting the unconstrained dataset in comparison with conventional CNN feature-based learning models, with a Dice score of 0.58 and displaying 96.7 % accuracy for real-time vein visualization, making it appropriate to locate veins in real-time under unconstrained conditions.

Conclusions

Self-parameterized U-Net for vein segmentation and visualization has the potential to reduce risks associated with traditional venipuncture or CVD treatments by outperforming conventional CNN architectures, providing vascular assistance, and improving patient care and treatment outcomes.


Corresponding author: Amit Laddi, PhD, ME, B.Tech (Hons.), Senior Principal Scientist, Biomedical Applications Group, CSIR-Central Scientific Instruments Organisation (CSIO), Chandigarh 160030, India; and Asst. Professor, Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201 002, Uttar Pradesh, India, E-mail:

Acknowledgments

Authors are thankful to CSIR India for project grants HCP-026 (Task 3.1) and OLP-0271. Authors acknowledge CSIR-Central Scientific Instruments Organisation (CSIO), Chandigarh, India, and Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India, for the infrastructure facilities and support in carrying out this research work.

  1. Research ethics: This study was performed in line with the approvals of the Institutional Ethics Committee (IEC), CSIR-CSIO, India (Ref: IEC/CSIO/2021/09, Dated 25th June 2021).

  2. Informed consent: Informed consent was obtained from all individuals included in this study.

  3. Author contributions: The authors have accepted responsibility for the entire content of this manuscript and approved its submission. The contribution of each author are summerised as: Shivalika Goyal: Study design, analysis and interpretation of results, manuscript writing/compilation; Himani: Patient data collection, data design, and results; Ajay Savlania: Medical inputs in designing protocol and study validation, manuscript review; Amit Laddi: Study conception, critical review and manuscript editing.

  4. Competing interests: The authors state no conflict of interest.

  5. Research funding: The study and experimental work has been funded by Council of Scientific and Industrial Research (CSIR) under Medical Instruments and Devices Mission (HCP-26-3.1).

  6. Data availability: The raw data can be obtained on request from the corresponding author.

References

1. Eberhardt, RT, Raffetto, JD. Chronic venous insufficiency. Circulation 2005;111:2398–409. https://doi.org/10.1161/01.cir.0000164199.72440.08.Suche in Google Scholar PubMed

2. Bergan, JJ, Schmid-Schönbein, GW, Coleridge Smith, PD, Nicolaides, AN, Boisseau, MR, Eklof, B. Chronic venous disease from the departments of surgery; 2006. Available from: www.nejm.org.10.1056/NEJMra055289Suche in Google Scholar PubMed

3. Beebe-Dimmer, JL, Pfeifer, JR, Engle, JS, Schottenfeld, D. The epidemiology of chronic venous insufficiency and varicose veins. Ann Epidemiol 2005;15:175–84. https://doi.org/10.1016/j.annepidem.2004.05.015.Suche in Google Scholar PubMed

4. Alexandrou, E, Ray-Barruel, G, Carr, PJ, Frost, S, Inwood, S, Higgins, N, et al.. International prevalence of the use of peripheral intravenous catheters. J Hosp Med 2015;10:530–3. https://doi.org/10.1002/jhm.2389.Suche in Google Scholar PubMed

5. Pan, CT, Francisco, MD, Yen, CK, Wang, SY, Shiue, YL. Vein pattern locating technology for cannulation: a review of the low-cost vein finder prototypes utilizing near infrared (NIR) light to improve peripheral subcutaneous vein selection for phlebotomy. Sensors 2019;19:3573. https://doi.org/10.3390/s19163573.Suche in Google Scholar PubMed PubMed Central

6. Miyake, RK, Zeman, HD, Duarte, FH, Kikuchi, R, Ramacciotti, E, Lovhoiden, G, et al.. Vein imaging: a new method of near infrared imaging, where a processed image is projected onto the skin for the enhancement of vein treatment. Dermatol Surg 2006;32:1031–8. https://doi.org/10.1111/j.1524-4725.2006.32226.x.Suche in Google Scholar PubMed

7. Juric, S, Zalik, B. An innovative approach to near-infrared spectroscopy using a standard mobile device and its clinical application in the real-time visualization of peripheral veins. BMC Med Inf Decis Making 2014;14:100. https://doi.org/10.1186/s12911-014-0100-z.Suche in Google Scholar PubMed PubMed Central

8. Francisco, MD, Chen, WF, Pan, CT, Lin, MC, Wen, ZH, Liao, CF, et al.. Competitive real-time near infrared (NIR) vein finder imaging device to improve peripheral subcutaneous vein selection in venipuncture for clinical laboratory testing. Micromachines 2021;12:373. https://doi.org/10.3390/mi12040373.Suche in Google Scholar PubMed PubMed Central

9. Kanzawa, Y, Kimura, Y, Naito, T. Human skin detection by visible and near-infrared imaging. Nara, JAPAN: IAPR Conference on Machine Vision Applications, MVA2011, MVA Organization; 2011:503–7 pp.Suche in Google Scholar

10. Wang, L, Leedham, G, Cho, SY. Infrared imaging of hand vein patterns for biometric purposes. IET Comput Vis 2007;1:113–22. https://doi.org/10.1049/iet-cvi:20070009.10.1049/iet-cvi:20070009Suche in Google Scholar

11. Hashimoto, Junichi. Finger vein authentication technology and its future. In: IEEE Symposium on VLSI circuits, 2006. Digest of Technical Papers, Honolulu, HI, USA; 2006: 5–8 pp.Suche in Google Scholar

12. Girshick, R, Donahue, J, Darrell, T, Malik, J. Rich feature hierarchies for accurate object detection and semantic segmentation. In: 2014 IEEE Conference on Computer Vision and Pattern Recognition, Columbus, OH, USA. IEEE, New York City; 2014: 580–87 pp.10.1109/CVPR.2014.81Suche in Google Scholar

13. Garcia-Garcia, A, Orts-Escolano, S, Oprea, S, Villena-Martinez, V, Martinez-Gonzalez, P, Garcia-Rodriguez, J. A survey on deep learning techniques for image and video semantic segmentation. Appl Soft Comput J 2018;70:41–65.10.1016/j.asoc.2018.05.018Suche in Google Scholar

14. Jin, Q, Chen, Q, Meng, Z, Wang, B, Su, R. Construction of retinal vessel segmentation models based on convolutional neural network. Neural Process Lett 2020;52:1005–22. https://doi.org/10.1007/s11063-019-10011-1.Suche in Google Scholar

15. Li, X, Jiang, Y, Li, M, Yin, S. Lightweight attention convolutional neural network for retinal vessel image segmentation. IEEE Trans Ind Inf 2021;17:1958–67. https://doi.org/10.1109/tii.2020.2993842.Suche in Google Scholar

16. Jiang, Y, Zhang, H, Tan, N, Chen, L. Automatic retinal blood vessel segmentation based on fully convolutional neural networks. Symmetry 2019;11:1112. https://doi.org/10.3390/sym11091112.Suche in Google Scholar

17. Lefkovits, S, Lefkovits, L, Szilágyi, L. CNN approaches for dorsal hand vein based identification. Comp Sci Res Notes 2019;51–60. https://doi.org/10.24132/csrn.2019.2902.2.7.Suche in Google Scholar

18. Leli, Vito, M., Aleksandr Rubashevskii, Aleksandr Sarachakov, Oleg Rogov, and Dmitry, V. Dylov. Near-infrared-to-visible vein imaging via convolutional neural networks and reinforcement learning. In: 2020 16th International Conference on Control, Automation, Robotics and Vision (ICARCV), Shenzhen, China. IEEE, New York City; 2020: 434–41 pp.10.1109/ICARCV50220.2020.9305503Suche in Google Scholar

19. Cuper, NJ, Klaessens, JHG, Jaspers, JEN, de Roode, R, Noordmans, HJ, de Graaff, JC, et al.. The use of near-infrared light for safe and effective visualization of subsurface blood vessels to facilitate blood withdrawal in children. Med Eng Phys 2013;35:433–40. https://doi.org/10.1016/j.medengphy.2012.06.007.Suche in Google Scholar PubMed

20. Henderson, TA, Morries, L. Near-infrared photonic energy penetration: can infrared phototherapy effectively reach the human brain? Neuropsychiatr Dis Treat 2015;11:2191–208. https://doi.org/10.2147/ndt.s78182.Suche in Google Scholar

21. Ai, D, Yang, J, Fan, J, Zhao, Y, Song, X, Shen, J, et al.. Augmented reality based real-time subcutaneous vein imaging system. Biomed Opt Express 2016;7:2565. https://doi.org/10.1364/boe.7.002565.Suche in Google Scholar

22. Sonka, M, Hlavac, V, Boyle, R. Image pre-processing. In: Image processing, analysis and machine vision. Boston, MA: Springer US; 1993:56–111 pp.10.1007/978-1-4899-3216-7_4Suche in Google Scholar

23. Cheng, HD, Shi, XJ. A simple and effective histogram equalization approach to image enhancement. Digit Signal Process 2004;14:158–70. https://doi.org/10.1016/j.dsp.2003.07.002.Suche in Google Scholar

24. Reza, AM. Realization of the contrast limited adaptive histogram equalization (CLAHE) for real-time image enhancement. J VLSI Signal Process 2004;38:35–44.10.1023/B:VLSI.0000028532.53893.82Suche in Google Scholar

25. Shorten, C, Khoshgoftaar, TM. A survey on image data augmentation for deep learning. J Big Data 2019;6:60. https://doi.org/10.1186/s40537-019-0197-0.Suche in Google Scholar

26. Zhang, R, Du, L, Xiao, Q, Liu, J. Comparison of backbones for semantic segmentation network. J Phys Conf Ser 2020;1544:012196. https://doi.org/10.1088/1742-6596/1544/1/012196.Suche in Google Scholar

27. Walsh, I, Fishman, D, Garcia-Gasulla, D, Titma, T, Pollastri, G, Capriotti, E, et al.. Author correction: DOME: recommendations for supervised machine learning validation in biology. Nat Methods 2021;18:1409–10. https://doi.org/10.1038/s41592-021-01304-2.Suche in Google Scholar PubMed

28. Simonyan, K, Zisserman, A. Very deep convolutional networks for large-scale image recognition. In: 3rd International Conference on Learning Representations (ICLR 2015). Computational and Biological Learning Society; 2015:1–14 pp.Suche in Google Scholar

29. Koonce, B. VGG network. In: Convolutional neural networks with swift for Tensorflow. Berkeley, CA: Apress; 2021:35–50 pp.10.1007/978-1-4842-6168-2_4Suche in Google Scholar

30. He, K, Zhang, X, Ren, S, Sun, J. Deep residual learning for image recognition. In: Proceedings of the IEEE conference on computer vision and pattern recognition, Las Vegas, NV, USA. New York City: IEEE; 2016:770–8 pp.10.1109/CVPR.2016.90Suche in Google Scholar

31. Alom, MZ, Yakopcic, C, Hasan, M, Taha, TM, Asari, VK. Recurrent residual U-Net for medical image segmentation. J Med Imaging 2019;6:1. https://doi.org/10.1117/1.jmi.6.1.014006.Suche in Google Scholar PubMed PubMed Central

32. Ronneberger, O, Fischer, P, Brox, T. U-net: convolutional networks for biomedical image segmentation. In: Medical image computing and computer-assisted intervention–MICCAI 2015: 18th international conference, Munich, Germany. Heidelberg: Springer International Publishing; 2015:234–41 pp.10.1007/978-3-319-24574-4_28Suche in Google Scholar

33. Xiao, Xiao, Shen Lian, Luo, Zhiming, Shaozi, Li. Weighted res-unet for high-quality retina vessel segmentation. In: 9th international conference on information technology in medicine and education (ITME). Hangzhou, China: IEEE; 2018:327–31 pp.10.1109/ITME.2018.00080Suche in Google Scholar

34. Rahman, MA, Wang, Y. Optimizing intersection-over-union in deep neural networks for image segmentation; 2016. 234–44 pp.10.1007/978-3-319-50835-1_22Suche in Google Scholar

35. Eelbode, T, Bertels, J, Berman, M, Vandermeulen, D, Maes, F, Bisschops, R, et al.. Optimization for medical image segmentation: theory and practice when evaluating with dice score or Jaccard index. IEEE Trans Med Imag 2020;39:3679–90. https://doi.org/10.1109/tmi.2020.3002417.Suche in Google Scholar

Received: 2023-07-19
Accepted: 2024-04-03
Published Online: 2024-04-24
Published in Print: 2024-10-28

© 2024 Walter de Gruyter GmbH, Berlin/Boston

Heruntergeladen am 13.4.2026 von https://www.degruyterbrill.com/document/doi/10.1515/bmt-2023-0331/html
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