A mock heart engineered with helical aramid fibers for in vitro cardiovascular device testing
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So-Hyun Jansen-Park
, Po-Lin Hsu
Abstract
Mock heart circulation loops (MHCLs) serve as in-vitro platforms to investigate the physiological interaction between circulatory systems and cardiovascular devices. A mock heart (MH) engineered with silicone walls and helical aramid fibers, to mimic the complex contraction of a natural heart, has been developed to advance the MHCL previously developed in our group. A mock aorta with an anatomical shape enables the evaluation of a cannulation method for ventricular assist devices (VADs) and investigation of the usage of clinical measurement systems like pressure-volume catheters. Ventricle and aorta molds were produced based on MRI data and cast with silicone. Aramid fibers were layered in the silicone ventricle to reproduce ventricle torsion. A rotating hollow shaft was connected to the apex enabling the rotation of the MH and the connection of a VAD. Silicone wall thickness, aramid fiber angle and fiber pitch were varied to generate different MH models. All MH models were placed in a tank filled with variable amounts of water and air simulating the compliance. In this work, physiological ventricular torsion angles (15°–26°) and physiological pressure-volume loops were achieved. This MHCL can serve as a comprehensive testing platform for cardiovascular devices, such as artificial heart valves and cannulation of VADs.
References
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©2017 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Editorial
- Smart life support reloaded: design and control of complex therapeutic devices
- Special Issue Articles
- Benefits of object-oriented models and ModeliChart: modern tools and methods for the interdisciplinary research on smart biomedical technology
- Parametrization of an in-silico circulatory simulation by clinical datasets – towards prediction of ventricular function following assist device implantation
- Design of a right ventricular mock circulation loop as a test bench for right ventricular assist devices
- A mock heart engineered with helical aramid fibers for in vitro cardiovascular device testing
- Comparison of novel physiological load-adaptive control strategies for ventricular assist devices
- High-frequency operation of a pulsatile VAD – a simulation study
- Convolutive blind source separation of surface EMG measurements of the respiratory muscles
- Determining the appropriate model complexity for patient-specific advice on mechanical ventilation
- Physiological closed-loop control of mechanical ventilation and extracorporeal membrane oxygenation
- Decentralized safety concept for closed-loop controlled intensive care
- Model-based glycaemic control: methodology and initial results from neonatal intensive care
Articles in the same Issue
- Frontmatter
- Editorial
- Smart life support reloaded: design and control of complex therapeutic devices
- Special Issue Articles
- Benefits of object-oriented models and ModeliChart: modern tools and methods for the interdisciplinary research on smart biomedical technology
- Parametrization of an in-silico circulatory simulation by clinical datasets – towards prediction of ventricular function following assist device implantation
- Design of a right ventricular mock circulation loop as a test bench for right ventricular assist devices
- A mock heart engineered with helical aramid fibers for in vitro cardiovascular device testing
- Comparison of novel physiological load-adaptive control strategies for ventricular assist devices
- High-frequency operation of a pulsatile VAD – a simulation study
- Convolutive blind source separation of surface EMG measurements of the respiratory muscles
- Determining the appropriate model complexity for patient-specific advice on mechanical ventilation
- Physiological closed-loop control of mechanical ventilation and extracorporeal membrane oxygenation
- Decentralized safety concept for closed-loop controlled intensive care
- Model-based glycaemic control: methodology and initial results from neonatal intensive care