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In vitro comparison of two changeover methods for vasoactive drug infusion pumps: quick-change versus automated relay

  • Stéphanie Genay , Bertrand Décaudin EMAIL logo , Sébastien Lédé , Frédéric Feutry , Christine Barthélémy , Gilles Lebuffe and Pascal Odou
Published/Copyright: August 1, 2015
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Biomedical Engineering / Biomedizinische Technik
From the journal Biomedical Engineering / Biomedizinische Technik Volume 60 Issue 4

Abstract

This study aimed to compare in vitro two syringe changeover techniques to determine which was better at minimising variations in norepinephrine (NE) delivery: the manual quick-change or automated technique. NE concentration was measured continuously using a UV spectrophotometer, and infusion flow rate was monitored by an infusion pump tester. Syringe changeovers were made with either of the two techniques studied. Relays induced disturbances in drug delivery. The temporary increase in NE mass flow rate was significantly higher with manual relays than with automated ones. The automated relay offered a better control of the amounts of NE administered than the quick-change technique.

Keywords: administration and dosage; infusion pumps; infusions; instrumentation; intravenous; syringes; vasoconstrictor agents
Corresponding author: Bertrand Décaudin, Laboratoire de Biopharmacie, Pharmacie Galénique, Hospitalière, 3, rue du Professeur Laguesse, BP 83, 59006 Lille Cedex, France, Phone: +33 (0)320964029, Fax: +33 (0)320959009, E-mail: ; and University of Lille Nord de France, F-59000 Lille, France; EA GRITA, F-59000 Lille, France; and Pharmacy, CHULille, F-59000 Lille, France

References

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Received: 2014-10-27
Accepted: 2015-7-10
Published Online: 2015-8-1
Published in Print: 2015-8-1

©2015 by De Gruyter

Articles in the same Issue

  1. Frontmatter
  2. Editorial
  3. Low liquid flows – an important aspect in medical technology
  4. Special issue articles
  5. Metrology for drug delivery
  6. Flow variability and its physical causes in infusion technology: a systematic review of in vitro measurement and modeling studies
  7. Primary standards for measuring flow rates from 100 nl/min to 1 ml/min – gravimetric principle
  8. Primary standard for liquid flow rates between 30 and 1500 nl/min based on volume expansion
  9. An experimental setup for traceable measurement and calibration of liquid flow rates down to 5 nl/min
  10. Assessment of drug delivery devices
  11. An adjustable flow restrictor for implantable infusion pumps based on porous ceramics
  12. How physical infusion system parameters cause clinically relevant dose deviations after setpoint changes
  13. In vitro comparison of two changeover methods for vasoactive drug infusion pumps: quick-change versus automated relay
  14. How to use current practice, risk analysis and standards to define hospital-wide policies on the safe use of infusion technology
https://doi.org/10.1515/bmt-2014-0140
Keywords for this article
administration and dosage; infusion pumps; infusions; instrumentation; intravenous; syringes; vasoconstrictor agents

Articles in the same Issue

  1. Frontmatter
  2. Editorial
  3. Low liquid flows – an important aspect in medical technology
  4. Special issue articles
  5. Metrology for drug delivery
  6. Flow variability and its physical causes in infusion technology: a systematic review of in vitro measurement and modeling studies
  7. Primary standards for measuring flow rates from 100 nl/min to 1 ml/min – gravimetric principle
  8. Primary standard for liquid flow rates between 30 and 1500 nl/min based on volume expansion
  9. An experimental setup for traceable measurement and calibration of liquid flow rates down to 5 nl/min
  10. Assessment of drug delivery devices
  11. An adjustable flow restrictor for implantable infusion pumps based on porous ceramics
  12. How physical infusion system parameters cause clinically relevant dose deviations after setpoint changes
  13. In vitro comparison of two changeover methods for vasoactive drug infusion pumps: quick-change versus automated relay
  14. How to use current practice, risk analysis and standards to define hospital-wide policies on the safe use of infusion technology
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