Treatment of arrhythmias by external charged particle beams: a Langendorff feasibility study
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Matthias Prall
, H. Immo Lehmann
Abstract
Hadron therapy has already proven to be successful in cancer therapy, and might be a noninvasive alternative for the ablation of cardiac arrhythmias in humans. We present a pilot experiment investigating acute effects of a 12C irradiation on the AV nodes of porcine hearts in a Langendorff setup. This setup was adapted to the requirements of charged particle therapy. Treatment plans were computed on calibrated CTs of the hearts. Irradiation was applied in units of 5 and 10 Gy over a period of about 3 h until a total dose of up to 160 Gy was reached. Repeated application of the same irradiation field helped to mitigate motion artifacts in the resulting dose distribution. After irradiation, PET scans were performed to verify accurate dose application. Acute AV blocks were identified. No other acute effects were observed. Hearts were kept in sinus rhythm for up to 6 h in the Langendorff setup. We demonstrated that 12C ions can be used to select a small target in the heart and, thereby, influence the electrical conduction system. Second, our pilot study seems to suggest that no adverse effects have to be expected immediately during heavy ion irradiation in performing subsequent experiments with doses of 30–60 Gy and intact pigs.
Correction Note
Corrections added after online publication February 19, 2015: Regrettably reference [17] was placed incorrectly in the first online version.
Acknowledgments
We thank the German Research Foundation (DFG) for funding this work as part of the Clinical Research Group (KFO) 214/2 and the Helmholtz Association for funding of this work through Helmholtz-Portfolio Topic “Technology and Medicine”.
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©2015 by De Gruyter
Artikel in diesem Heft
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Artikel in diesem Heft
- Frontmatter
- Review
- Resonant marker design and fabrication techniques for device visualization during interventional magnetic resonance imaging
- Research Articles
- Preparation of spherical calcium phosphate granulates suitable for the biofunctionalization of active brazed titanium alloy coatings
- Measurement of the axial and circumferential mechanical properties of rat skin tissue at different anatomical locations
- The Intra-Cochlear Impedance-Matrix (IIM) test for the Nucleus® cochlear implant
- Magnetoencephalographic accuracy profiles for the detection of auditory pathway sources
- Treatment of arrhythmias by external charged particle beams: a Langendorff feasibility study
- Effect of angular stability and other locking parameters on the mechanical performance of intramedullary nails
- Prophylactic bioactive screw fixation as an alternative augmentation for femoroplasty
- Volume of confidence ellipsoid: a technique for quantifying trunk sway during stance