Startseite Medizin Bioartificial fabrication of regenerating blood vessel substitutes: requirements and current strategies
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Bioartificial fabrication of regenerating blood vessel substitutes: requirements and current strategies

  • Mathias Wilhelmi , Stefan Jockenhoevel und Petra Mela EMAIL logo
Veröffentlicht/Copyright: 1. März 2014

Abstract

This work reviews the tremendous development in the field of vascular graft tissue engineering driven by a clear and increasing clinical need for functional vascular replacements able to grow and remodel. The different strategies to tissue engineer blood vessels are presented, from the classical approach of a living implant generated in vitro by conditioning a cell-seeded scaffold to remarkable paradigm shifts either i) toward a completely biology-driven strategy (scaffold-free approaches) or ii) the opposite tendency of cell-free scaffolds aiming at eliciting the host reaction for in situ tissue engineering. In the scaffold-based approaches emphasis is given to the material choice.


Corresponding author: Petra Mela, Department of Tissue Engineering and Textile Implants, Applied Medical Engineering, Helmholtz Institute, RWTH Aachen University, Pauwelsstr. 20, 52072 Aachen, Germany, Phone: +49 241 80 89886, Fax: +49 241 80 23402, E-mail: ;

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Received: 2013-10-18
Accepted: 2014-2-3
Published Online: 2014-3-1
Published in Print: 2014-6-1

©2014 by Walter de Gruyter Berlin/Boston

Heruntergeladen am 6.2.2026 von https://www.degruyterbrill.com/document/doi/10.1515/bmt-2013-0112/pdf
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