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Laser microstructured biodegradable scaffolds

  • Anastasia Koroleva , Olga Kufelt , Sabrina Schlie-Wolter , Ulf Hinze and Boris Chichkov EMAIL logo
Published/Copyright: May 28, 2013

Abstract

The two-photon polymerization technique (2PP) uses non-linear absorption of femtosecond laser pulses to selectively polymerize photosensitive materials. 2PP has the ability to fabricate structures with a resolution from tens of micrometers down to hundreds of nanometers. Three-dimensional microstructuring by the 2PP technique provides many interesting possibilities for biomedical applications. This microstructuring technique is suitable with many biocompatible polymeric materials, such as polyethylene glycol, polylactic acid, polycaprolactone, gelatin, zirconium-based hybrids, and others. The process of fabrication does not require clean room conditions and does not use hazard chemicals or high temperatures. The most beneficial property of 2PP is that it is capable of producing especially complex three-dimensional (3-D) structures, including devices with overhangs, without using any supportive structure. The flexibility in controlling geometries and feature sizes and the possibility to fabricate structures without the addition of new material layers makes this technique particularly appealing for fabrication of 3-D scaffolds for tissue engineering.


Corresponding author: Boris Chichkov, Laser Zentrum Hannover, Nanotechnology, Hollerithallee 8, Hannover 30419, Germany, E-mail:

This work was supported by the DFG excellence cluster Rebirth, “From Regenerative Biology to Reconstructive Therapy.” The authors thank A. Deiwick (LZH) for performing the stem cell studies.

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Received: 2012-12-12
Accepted: 2013-4-29
Published Online: 2013-05-28
Published in Print: 2013-10-01

©2013 by Walter de Gruyter Berlin Boston

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