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Comparison of commercial iron oxide-based MRI contrast agents with synthesized high-performance MPI tracers

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Published/Copyright: June 20, 2013
Biomedizinische Technik/Biomedical Engineering
From the journal Biomedizinische Technik/Biomedical Engineering Volume 58 Issue 6

Abstract

Magnetic particle imaging (MPI) recently emerged as a new tomographic imaging method directly visualizing the amount and location of superparamagnetic iron oxide particles (SPIOs) with high spatial resolution. To fully exploit the imaging performance of MPI, specific requirements are demanded on the SPIOs. Most important, a sufficiently high number of detectable harmonics of the receive signal spectrum is required. In this study, an assessment of commercial iron oxide-based MRI contrast agents is carried out, and the result is compared with that of a new self-synthesized high-performance MPI tracer. The decay of the harmonics is measured with a magnetic particle spectrometer (MPS). For the self-synthesized carboxymethyldextran-coated SPIO, it can be demonstrated that despite a small iron core diameter, the particle performance is as good as in Resovist, the best-performing commercial SPIO today. However, the self-synthesized particles show the lowest iron concentration compared with Resovist, Sinerem, and Endorem. As the iron dose will be an important issue in human MPI, the synthesis technique and the separation chain for self-synthesis will be pursued for further improvements. In evaluations carried out with MPS, it can be shown in this work that the quality of the self-synthesized nanoparticles outperforms the three commercial tracer materials when the decay of harmonics is normalized by the iron concentration. The results of this work emphasize the importance of producing highly uniform and monodisperse superparamagnetic particles contributing to lower application of tracer concentration, better sensitivity, or a higher spatial resolution.

Keywords: iron oxide; magnetic particle imaging; magnetic particle spectroscopy; nanoparticles; SPIO
Corresponding author: Kerstin Lüdtke-Buzug, Institute of Medical Engineering, University of Lübeck, Ratzeburger Allee 160, Lübeck 23562, Germany, E-mail:

This work was financially supported by the Innovation Foundation (ISH) of the state of Schleswig-Holstein, Germany (grant ID 2007-60). It is also part of the University Research Program “Imaging of Disease Processes”, University of Lübeck.

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Received: 2012-12-4
Accepted: 2013-5-28
Published Online: 2013-06-20
Published in Print: 2013-12-01

©2013 by Walter de Gruyter Berlin Boston

Articles in the same Issue

  1. Masthead
  2. Masthead
  3. Editorial
  4. Magnetic Particle Imaging – from particle science to imaging technology
  6. Tailoring the magnetic and pharmacokinetic properties of iron oxide magnetic particle imaging tracers
  7. Synthetic routes to magnetic nanoparticles for MPI
  8. Red blood cells as carriers in magnetic particle imaging
  9. Comparison of commercial iron oxide-based MRI contrast agents with synthesized high-performance MPI tracers
  10. Characterization of magnetic nanoparticle systems with respect to their magnetic particle imaging performance
  11. Magnetic spectroscopy of nanoparticle Brownian motion measurement of microenvironment matrix rigidity
  12. Perspectives on clinical magnetic particle imaging
  13. Magnetic particle imaging scanner with 10-kHz drive-field frequency
  14. Twenty-fold acceleration of 3D projection reconstruction MPI
  15. Improved field free line magnetic particle imaging using saddle coils
  16. On the formulation of the image reconstruction problem in magnetic particle imaging
  17. Numerically efficient estimation of relaxation effects in magnetic particle imaging
  18. Simulation of the magnetization dynamics of diluted ferrofluids in medical applications
  19. Safety considerations for magnetic fields of 10 mT to 100 mT amplitude in the frequency range of 10 kHz to 100 kHz for magnetic particle imaging
https://doi.org/10.1515/bmt-2012-0059
Keywords for this article
iron oxide; magnetic particle imaging; magnetic particle spectroscopy; nanoparticles; SPIO

Articles in the same Issue

  1. Masthead
  2. Masthead
  3. Editorial
  4. Magnetic Particle Imaging – from particle science to imaging technology
  6. Tailoring the magnetic and pharmacokinetic properties of iron oxide magnetic particle imaging tracers
  7. Synthetic routes to magnetic nanoparticles for MPI
  8. Red blood cells as carriers in magnetic particle imaging
  9. Comparison of commercial iron oxide-based MRI contrast agents with synthesized high-performance MPI tracers
  10. Characterization of magnetic nanoparticle systems with respect to their magnetic particle imaging performance
  11. Magnetic spectroscopy of nanoparticle Brownian motion measurement of microenvironment matrix rigidity
  12. Perspectives on clinical magnetic particle imaging
  13. Magnetic particle imaging scanner with 10-kHz drive-field frequency
  14. Twenty-fold acceleration of 3D projection reconstruction MPI
  15. Improved field free line magnetic particle imaging using saddle coils
  16. On the formulation of the image reconstruction problem in magnetic particle imaging
  17. Numerically efficient estimation of relaxation effects in magnetic particle imaging
  18. Simulation of the magnetization dynamics of diluted ferrofluids in medical applications
  19. Safety considerations for magnetic fields of 10 mT to 100 mT amplitude in the frequency range of 10 kHz to 100 kHz for magnetic particle imaging
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