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Characterization of magnetic nanoparticle systems with respect to their magnetic particle imaging performance

  • Frank Ludwig EMAIL logo , Dietmar Eberbeck , Norbert Löwa , Uwe Steinhoff , Thilo Wawrzik , Meinhard Schilling and Lutz Trahms
Published/Copyright: June 8, 2013

Abstract

The optimization of magnetic nanoparticles (MNPs) as markers for magnetic particle imaging (MPI) requires an understanding of the relationship between the harmonics spectrum and the structural and magnetic properties of the MNPs. Although magnetic particle spectroscopy (MPS) – carried out at the same excitation frequency as the given MPI system – represents a straightforward technique to study MNPs for their suitability for MPI, a complete understanding of the mechanisms and differences between different tracer materials requires additional measurements of the static and dynamic magnetic behavior covering additional field and time ranges. Furthermore, theoretical models are needed, which correctly account for the static and dynamic magnetic properties of the markers. In this paper, we give an overview of currently used theoretical models for the explanation of amplitude and phase of the harmonics spectra as well as of the various static and dynamic magnetic techniques, which are applied for the comprehensive characterization of MNPs for MPI. We demonstrate on two multicore MNP model systems, Resovist® and FeraSpin™ Series, how a detailed picture of the MPI performance can be obtained by combining various static and dynamic magnetic measurements.


Corresponding author: Dr. Frank Ludwig, Institut für Elektrische Messtechnik und Grundlagen der Elektrotechnik, TU Braunschweig, Hans-Sommer-Str. 66, 38106 Braunschweig, Germany, Phone: +49 531 3913863, E-mail:

The research was supported by the German Ministry for Education and Research (Grant No. FKZ 13N11092).

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Received: 2013-1-31
Accepted: 2013-5-13
Published Online: 2013-06-08
Published in Print: 2013-12-01

©2013 by Walter de Gruyter Berlin Boston

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