A processing scheme for time-variant phase analysis in EEG burst activity of premature and full-term newborns in quiet sleep: a methodological study
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Matthias Wacker
Abstract
A processing scheme for the investigation of neonatal electroencephalographic burst oscillations that is composed of time-variant methods for linear and nonlinear phase analysis is introduced. Starting from a time-frequency analysis of oscillations’ amplitudes, time-variant approaches for quantification of phase locking, n:m phase synchronization, and quadratic phase coupling are applied. Tracé discontinue patterns from premature newborns and tracé alternant patterns from full-term newborns were investigated using bipolar EEG recordings. Maturation-related differences between the burst generation mechanisms can be shown, which are reflected in group-specific patterns of augmentation, timing, and grouping of time-varying phase characteristics of the EEG burst oscillations. We demonstrate for both groups (premature and full-term newborns) that phase-locked low-frequency oscillations are pronounced in the frequency range of 0.5–1.5 Hz. Phase-locked oscillations also occur in a frequency range of >3 Hz. The amplitude of a phase-locked 2-Hz oscillation is higher in full-term than in premature newborns. After onset, n:m synchronization and an increase in bicoherence occur earlier in the premature group (between 0.5–1.5 Hz and 3.0–6.0 Hz). It can be suggested that during the maturation process, the driving force of thalamic structures decreases and that cortical activity plays an increasingly important role in the process of burst generation.
We thank Dr. A.M. d’Allest for support in neurological and clinical assessment of premature neonates and Dr. L. Curzi-Dascalova for the support in sleep state classification in premature neonates. M. Eiselt worked from January to October 1991 at the Hôpital A. Béclère, Clamart – Paris, Laboratory of Physiology (director, Dr. L. Curzi-Dascalova), on the basis of a research fellowship from the French government. During this period, the premature infants had been investigated in the Neonatal Service, Hôpital A. Béclère, Clamart-Paris. This study was supported by the Deutsche Forschungsgemeinschaft DFG Wi 1166/10-2.
Appendix
Recording conditions of premature and full-term neonates
The data of the premature neonates were recorded with a 16-channel polygraph (Reega 2000, Alvar). The four longitudinal montages, Fp1-T3, Fp2-T4, C3-O1, and C4-O2, were recorded and stored together with other parameters (for details, see Eiselt et al. [11]) by use of a PHILIPS 7-track tape recorder. Signals were digitized with 281 Hz by a MASSCOMP signal analyzer (Massachusetts computer corporation, Boston, MA, USA), which transformed analogic tapes to digital streamer tapes (10-bit real amplitude resolution in our data). The digitized signals were taken over by a Sun4 computer.
The polysomnographic data of full-term neonates were recorded at the Jena University Hospital (Department of Obstetrics and Gynecology) by M. Eiselt in 1987. The EEG was recorded by an eight-channel device (Bioscript BST-1, Messgerätewerk Zwönitz) and stored on a TESLA 14-track FM-tape recorder (EAM 500). The stored unipolar EEG recordings were digitized by a 12-bit analog-digital converter DT 21-EZ (Data Translation) by using 128-Hz sampling frequency (own data acquisition program). The real amplitude resolution of our data is 10 bits. The four longitudinal montages were computed from the unipolar EEG signals.
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Artikel in diesem Heft
- Masthead
- Masthead
- Editorial
- Technically assisted rehabilitation
- Research Articles
- How to gain evidence in neurorehabilitation: a personal view
- Stair ascent with an innovative microprocessor-controlled exoprosthetic knee joint
- Assistive acting movement therapy devices with pneumatic rotary-type soft actuators
- Development of a neurotechnological system for relieving phantom limb pain using transverse intrafascicular electrodes (TIME)
- Antimicrobial surface coatings for a permanent percutaneous passage in the concept of osseointegrated extremity prosthesis
- Correlation of pull-out strength of cement-augmented pedicle screws with CT-volumetric measurement of cement
- SVSVGMKPSPRP: a broad range adhesion peptide
- A processing scheme for time-variant phase analysis in EEG burst activity of premature and full-term newborns in quiet sleep: a methodological study
