Paraoxonase 1 activity and polymorphisms in multiple sclerosis patients
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Monika Ď Ďurfinová
,
Radka Bartová
Abstract
The pathophysiology of multiple sclerosis (MS) includes also the vascular abnormalities. Recent reports on changes in venous cerebrospinal outflow and the investigation of immunomodulatory properties of several vascular mediators on the molecular level have added new information to hypotheses on vascular pathology as determining factor in the pathophysiology of MS. We assessed changes in serum paraoxonase 1 (PON1) activities in MS patients and polymorphism of PON1 as a risk factor for MS. The main role of serum PON1 is hydrolysis of lipid peroxides and protection of lowdensity lipoprotein particles from oxidation. These events could play a role in lowering the risk of atherogenesis and vascular complications development in MS. There are controversial results about association of two main polymorphisms in paraoxonase coding region (PON1 55L/M, PON1 192Q/R) and risk of MS in different populations. Our results support studies that PON1 polymorphisms are probably not a risk factor of MS development.
References
Allen N.B., Lichtman J.H., Cohen H.W., Fang J., Brass L.M. & Alderman M.H. 2008. Vascular disease among hospitalized multiple sclerosis patients. Neuroepidemiology 30: 234-238.10.1159/000128103Suche in Google Scholar
Aviram M., Rosenblat M., Billecke S., Erogul J., Sorenson R. & Bisgaier C.L. 1999. Human serum paraoxonase (PON1) is inactivated by oxidized low density lipoprotein and preserved by antioxidants. Free Radical Biol. Med. 26: 892-904.10.1016/S0891-5849(98)00272-XSuche in Google Scholar
Bassett C.N. & Montine T.J. 2003. Lipoproteins and lipid peroxidation in Alzheimer’s disease. J. Nutr. Health Aging 7: 24-29.Suche in Google Scholar
Diekstra F.P., Beleza-Meireles A., Leigh N.P., Shaw C.E. & Al- Chalabi A. 2009. Interaction between PON1 and population density in amyotrophic lateral sclerosis. Neuroreport 20: 186-190.10.1097/WNR.0b013e32831af220Suche in Google Scholar
Draganov D.I. & La Du B.N. 2004. Pharmacogenetics of paraoxonases: a brief review. Naunyn Schmiedebergs Arch. Pharmacol. 369: 78-88.10.1007/s00210-003-0833-1Suche in Google Scholar
Duric G., Svetel M., Nikolaevic S.I., Dragadevic N., Gavrilovic J. & Kostic V.S. 2007. Polymorphism in the genes of cytochrome oxidase P450 2D6 (CYP2D6), paraoxonase 1 (PON1) and apolipoprotein E (APOE) as risk factors for Parkinson’s disease. Vojnosanitetski Pregled 64: 25-30.Suche in Google Scholar
Ferretti G., Bacchetti T., Principi F., Di Ludovico F., Viti B., Angeleri V.A., Danni M. & Provinciali L. 2005. Increased levels of lipid hydroperoxides in plasma of patients with multiple sclerosis: a relationship with paraoxonase activity. Mult. Scler. 11: 677-682.10.1191/1352458505ms1240oaSuche in Google Scholar
Hadjigeorgiou G.M., Malizos K., Dardiotis E., Aggelakis K., Dardioti M., Zibis A., Dimitroulias A., Scarmeas N., Tsezou A. & Karantanas A. 2007. Paraoxonase 1 gene polymorphisms in patients with osteonecrosis of the femoral head with and without cerebral white matter lesions. J. Orthop. Res. 25: 1087-1093.10.1002/jor.20393Suche in Google Scholar
Humbert R., Adler D.A., Disteche C.M., Hassett C., Omiecinski C.J. & Furlong C.E. 1993. The molecular-basis of the human serum paraoxonase activity polymorphism. Nat. Genet. 3: 73-76.10.1038/ng0193-73Suche in Google Scholar
Christiansen C.F., Christiansen S., Farkas D.K., Miret M., Sorensen H.T. & Pedersen L. 2010. Risk of arterial cardiovascular diseases in patients with multiple sclerosis: a population-based cohort study. Neuroepidemiology 35: 267-274.10.1159/000320245Suche in Google Scholar
Imai Y., Morita H., Kurihara H., Sugiyama T., Kato N., Ebihara A., Hamada C., Kurihara Y., Shindo T., Oh-Hashi Y. & Yazaki Y. 2000. Evidence for association between paraoxonase gene polymorphism and atherosclerotic diseases. Atherosclerosis 149: 435-442.10.1016/S0021-9150(99)00340-8Suche in Google Scholar
Inglese M., Park S.J., Johnson G., Babb J.S., Miles L., Jaggi H., Herbert J. & Grossman R.I. 2007. Deep gray matter perfusion in multiple sclerosis: dynamic susceptibility contrast perfusion magnetic resonance imaging at 3 T. Arch. Neurol. 64: 196-202.10.1001/archneur.64.2.196Suche in Google Scholar PubMed
Jamroz-Wisniewska A., Beltowski J., Stelmasiak Z. & Bartosik- Psujek H. 2009. Paraoxonase 1 activity in different types of multiple sclerosis. Mult. Scler. 15: 399-402.10.1177/1352458508098371Suche in Google Scholar
Law M., Saindane A.M., Ge Y., Babb J.S., Johnson G., Mannon L.J., Herbert J. & Grossman R.I. 2004. Microvascular abnormality in relapsing-remitting multiple sclerosis: perfusion MR imaging findings in normal-appearing white matter. Radiology 231: 645-652.10.1148/radiol.2313030996Suche in Google Scholar
Levine S.M. 1992. The role of reactive oxygen species in the pathogenesis of multiple sclerosis. Med. Hypotheses 39: 271-274.10.1016/0306-9877(92)90121-RSuche in Google Scholar
Martinez C., García-Martin E., Benito-León J., Calleja P., Díaz- Sanchez M., Pisa D., Alonso-Navarro H., Ayuso-Peralta L., Torrecilla D., Agúndez J.A.G. & Jiménez-Jiménez F.J. 2010. Paraoxonase 1 polymorphisms are not related with the risk for multiple sclerosis. Neuromol. Med. 12: 217-223.10.1007/s12017-009-8095-9Suche in Google Scholar PubMed
Moghtaderi A., Hashemi M., Sharafaddinzadeh N., Dabiri S., Moazeni-Roodi A., Ramroodi N. & Zolfaghari M. 2011. Lack of association between paraoxonase 1 Q192R polymorphism and multiple sclerosis in relapse phase: a case-control study. Clin. Biochem. 44: 795-798.10.1016/j.clinbiochem.2011.04.010Suche in Google Scholar PubMed
Polman C.H., Reingold S.C., Banwell B., Clanet M., Cohen J.A., Filippi M., Fujihara K., Havrdova E., Hutchinson M., Kappos L., Lublin F.D., Montalban X., O’Connor P., Sandberg- Wollheim M., Thompson A.J., Waubant E., Weinshenker B. & Wolinsky J.S. 2011. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann. Neurol. 69: 292-302.10.1002/ana.22366Suche in Google Scholar PubMed PubMed Central
Shin B.S., Oh S.Y., Kim Y.S. & Kim K.W. 2008. The paraoxonase gene polymorphism in stroke patients and lipid profile. Acta Neurol. Scand. 117: 237-243.10.1111/j.1600-0404.2007.00929.xSuche in Google Scholar PubMed
Sidoti A., Antognelli C., Rinaldi C., D’Angelo R., Dattola V., Girlanda P., Talesa V. & Amato A. 2007. Glyoxalase I A111E, paraoxonase 1 Q192R and L55M polymorphisms: susceptibility factors of multiple sclerosis? Mult. Scler. 13: 446-453.Suche in Google Scholar
Sýkora P., Repiská V. & Halčák L. 2010. Establishment of paraoxonase and arylesterase activity of paraoxonase 1 (PON1) in dependence on 55(L/M) and 192(Q/R) DNA polymorphism in adult people with Down syndrome. Journal of Special Education and Rehabilitation 11: 103-113.Suche in Google Scholar
Zamboni P., Galeotti R., Menegatti E., Malagoni A.M., Tacconi G., Dall’Ara S., Bartolomei I. & Salvi F. 2009. Chronic cerebrospinal venous insufficiency in patients with multiple sclerosis. J. Neurol. Neurosurg. Psychiatry 80: 392-399. 10.1136/jnnp.2008.157164Suche in Google Scholar PubMed PubMed Central
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Artikel in diesem Heft
- Escherichia coli expression of NDV fusion protein gene and determination of its antigenic epitopes
- Screening for fibrinolytic filamentous fungi and enzymatic properties of the most potent producer, Aspergillus brasiliensis AUMC 9735
- Biochemical, anatomical and molecular level changes in cucumber (Cucumis sativus) seedlings exposed to copper oxide nanoparticles
- Expression of bacterial glutamine synthetase gene in Arabidopsis thaliana increases the plant biomass and level of nitrogen utilization
- Comparison between natural and impacted Alpine lakes six years after hydropower exploitation has ceased
- Formation of radial symmetric needle-like rosette leaves in Arabidopsis
- Contribution to the knowledge of lohmanniid oribatid mites (Acari: Oribatida: Lohmanniidae) of Cuba
- Aquatic insects of a lowland rainforest in Papua New Guinea: assemblage structure in relation to habitat type
- Short-horned grasshopper subfamilies feed at different rates on big bluestem and switchgrass cultivars
- Nests of the harvest mouse (Micromys minutus) as habitat for invertebrates
- Comparison of the anatomical arrangement of the branches arising from the descending aorta in rabbit (Oryctolagus cuniculus f. domestica) and European hare (Lepus europaeus)
- Molecular dynamics simulation and docking studies on novel mutants (T11V, T12P and D364S) of the nucleotide-binding domain of human heat shock 70 kDa protein
- Paraoxonase 1 activity and polymorphisms in multiple sclerosis patients
