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Antibacterial activity of radical scavengers against class Ib ribonucleotide reductase from Bacillus anthracis
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Eduard Torrents
Published/Copyright:
February 26, 2010
Abstract
Bacillus anthracis is a severe mammalian pathogen. The deoxyribonucleotides necessary for DNA replication and repair are provided via the ribonucleotide reductase (RNR) enzyme. RNR is also important for spore germination and cell proliferation upon infection. We show that the expression of B. anthracis class Ib RNR responds to the environment that the pathogen encounters upon infection. We also show that several anti-proliferative agents (radical scavengers) specifically inhibit the B. anthracis RNR. Owing to the importance of RNR in the pathogenic infection process, our results highlight a promising potential to inhibit the growth of B. anthracis early during infection.
Received: 2010-10-21
Accepted: 2010-11-22
Published Online: 2010-02-26
Published in Print: 2010-02-26
©2010 by Walter de Gruyter Berlin New York
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- β-Catenin as a multilayer modulator of zonal cytochrome P450 expression in mouse liver
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- PROTEIN STRUCTURE AND FUNCTION
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- Peptides from the Mycobacterium tuberculosis Rv1980c protein involved in human cell infection: insights into new synthetic subunit vaccine candidates
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