Genetic background of urinary incontinence – state-of-the-art and perspectives
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Klaudia Stangel-Wjcikiewicz
und
Monika Piwowar
Abstract
The paper presents an overview of the current studies attempting to determine the genetic background of urinary incontinence (UI) problems. The overview referred to the adaptations of biomedical literature from Medline, life science journals, and online books were searched from the earliest date possible to March 2015. Genetic variability studies (mostly with the use of single nucleotide polymorphism) in the context of UI are discussed. The authors indicate the variability of polymorphic forms of proteins, whose modified function may be related to the observed phenotypic symptoms: UI. The paper includes a discussion of the varied level of gene expression and the issue of defective process of the development of the urinary system in the context of UI disorders. The literature does not present any general, unequivocal description of the relationship between the genetic background and phenotype as UI. It is suggested that the methods of integration of data from various techniques (e.g. high throughputs) in reference to social, demographic, and other data may be the way of the approach used for the effective description of the relationship between genetic background and observed UI.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
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©2015 by De Gruyter
Artikel in diesem Heft
- Frontmatter
- Reviews
- Genetic background of urinary incontinence – state-of-the-art and perspectives
- Modeling of metabolic diseases – a review of selected methods
- Research Articles
- Evaluation of Emotiv EEG neuroheadset
- Experimental research and modeling of selected layers of the trachea based on EBUS
- Application of S-transform to signal analysis
- The application of spherical standards for the evaluation of the accuracy of mapping shape in computed tomography
- Branched iterated function system (IFS) models with positioners for biological visualizations
- Rough assessment of GPU capabilities for parallel PCC-based biclustering method applied to microarray data sets
- Research on dynamics of the knee joint for different types of loads
- Modeling of lumbar spine equipped with fixator
Artikel in diesem Heft
- Frontmatter
- Reviews
- Genetic background of urinary incontinence – state-of-the-art and perspectives
- Modeling of metabolic diseases – a review of selected methods
- Research Articles
- Evaluation of Emotiv EEG neuroheadset
- Experimental research and modeling of selected layers of the trachea based on EBUS
- Application of S-transform to signal analysis
- The application of spherical standards for the evaluation of the accuracy of mapping shape in computed tomography
- Branched iterated function system (IFS) models with positioners for biological visualizations
- Rough assessment of GPU capabilities for parallel PCC-based biclustering method applied to microarray data sets
- Research on dynamics of the knee joint for different types of loads
- Modeling of lumbar spine equipped with fixator
