Abstract
Schistosomiasis is a debilitating parasitic disease, affects large number of host species. Currently affects 250-300 million people in tropic areas. Schistosoma pathogenic impact is hepatic periportal fibrosis; the parasite-induced inflammatory cellular activation promotes oxidative stress, resulting in lipid peroxidation (LPO), with subsequent increase in inflammatory mediators as malondialdehyde (MDA). This study was set up to reveal possible contribution of lipid peroxidation byproducts MDA in hepatic pathophysiology. Results displayed that MDA don’t tend to change in relation with either age, nor hepatic transaminases AST & ALT, while exhibited a significant increase in MDA levels in human schistosomiasis versus control group P<0.0001 (Mn. ± St.dev. 7.77 ± 3.59, 1.21 ± 0.28 nmol/ml) respectively. Moreover; MDA plasma levels in Schistosoma infected group correlated significantly with two hepatic fibrosis parameters; (a) ultrasonography graded periportal fibrosis P< 0.0001. Levels of MDA in hepatic fibrosis grades 0, I, II, III in Schistosoma infected group were (Mn. ± St.dev. 2.8 ± 0.64, 4.3 ± 1.2, 9.3 ± 1.6 and 10.8 ± 1.3 nmol/ml) respectively, (b) serum Hyaluronic acid (HA) P<0.0001 (spearman r = 0.77) as a reliable hepatic fibrosis marker. This implies a considerable role of LPO byproducts in schistosomiasis pathogenicity, and proposing malondialdehyde as a biomarker for schistosomiasis morbidity.
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W. Stefański Institute of Parasitology, PAS
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- A survey for potentially zoonotic gastrointestinal parasites of dogs and pigs in Cambodia
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- Coexistence of Borrelia burgdorferi s.l. genospecies within Ixodes ricinus ticks from central and eastern Poland
- Molecular characterization of cystic echinococcosis: First record of G7 in Egypt and G1 in Yemen
- Prevalence of Borrelia burgdorferi sensu lato in Ixodes ricinus ticks collected from southern Poland
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- Alveolar echinococcosis: how knowledgeable are primary care physicians and pharmacists in the Franche-Comté region of France?
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- Auto-infection by Echinostoma spp. cercariae in Helisoma anceps
- Risk factors of occurrence of Toxoplasma gondii among horses in the state of Alagoas, Brazil
- Cardiopulmonary helminths in foxes from the Pyrenees
- Risk of soil-transmitted helminth infections on agritourism farms in central and eastern Poland
- Evaluating the Babesia bovis infection of cattle in China with enzyme-linked immunosorbent assay (ELISA)
- Production and preliminary evaluation of Trypanosoma evansi HSP70 for antibody detection in Equids
- Malondialdehyde; Lipid peroxidation plasma biomarker correlated with hepatic fibrosis in human Schistosoma mansoni infection
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- First molecular identification of Ascocotyle (Phagicola) longa in its first intermediate host the mud snail Heleobia australis
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