iOCT with surgical microscopes: a new imaging during microsurgery
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Eva Maria Lankenau
Eva Maria Lankenau studied Physics at the University of Hamburg. In her Diploma Thesis, she analyzed the change of the temperature jump in protein mono-crystals under synchrotron and laser radiation experimentally. At the Medical Laser Center Luebeck, in cooperation with the University of Luebeck, she received her PhD for research and development in the field of optical coherence tomography (OCT). In her thesis, she analyzed and described the dispersion effects and applications in medical diagnosis with OCT. In 2009, she started her own project at the Institute of Biomedical Optics (BMO) at the University of Luebeck sponsored by the Federal Ministry BMWi (‘Exist-Forschungstransfer’), which enabled the formation of the company OptoMedical Technologies GmbH (OpMedT). Since 2010, she has been the Chief Executive Officer of the company that brings imaging and diagnostic methods such as optical coherence tomography to the new medical disciplines.
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Marc Krug
Marc Krug studied Physics at the University of Kassel. In his Diploma, he set up a velocity map imaging (VMI) spectrometer for investigations on the interaction of the ultrashort polarizationshaped femtosecond laser pulses with the alkali metal atoms. At the University of Kassel, he received his PhD for the measurements of the three-dimensional photoelectron angular distributions employing a novel tomographic reconstruction technique. In 2009, he joined the group of Dr. Eva Lankenau for preparing the foundation of the OptoMedical Technologies GmbH (OpMedT). Today, he is the Chief Operating Officer and Head of the R&D of OpMedT (Lübeck, Germany).
Stefan Oelckers studied Physics in Hamburg. In his Diploma, he was working on the medical applications of synchrotron radiation. His PhD and postdoc in Berlin were about photodynamic therapy, where he built up several spectroscopic setups and achieved the first optical detection of the ultra-weak singlet oxygen emission from the inside of the native biological membranes. At Moeller-Wedel, he does regular development and works on the new techniques for the surgical microscopes. He started the company’s cooperation with the BMO on OCT. After the completion of the government-funded BMO Project, Dr. Lankenau and he were very involved with the continuation of their visions that resulted in the foundation of the OptoMedical Technologies GmbH.
Norbert Schrage received his medical PhD in 1990 for the investigations of the severest acid burns of the corneas with scanning electron microscopy and X-ray structure analysis. In 1996, he received the board certification in Ophthalmology. With his habilitation in the field of chemical elements inside the cornea, he received his venia legendi in 1997. He is the chairman of the ACTO e.V. After he was Deputy Director of the Department of Ophthalmology in Aachen, he is now the Head of the Department of Ophthalmology in Cologne Merheim since 2004.
Tino Just studied Medicine at the University of Rostock in Germany. He received his MD from the University of Rostock in 1999. He finished his habilitation in 2006 and received the permission for lecturing (facultas docendi) in 2007. In 2003, he received the board certification in Otorhinolaryngology. Dr. Just is a fully trained surgeon in the field of otorhinolaryngology with specialties in ear surgery (cochlear implant, implantable hearing aids), plastic surgery, and laryngeal surgery. Today, he is the Senior Consultant and Deputy Director of the Department of Otorhinolaryngology in Rostock.
Gereon Hüttmann received, in 1988, the Master of Science degree in Physics and, in 1992, his PhD in Physical Chemistry from the University of Göttingen. From 1992 to 2005, he is a research member of the Medical Laser Center in Lübeck, Germany, working in the fields of photodynamic therapy and fluorescence detection of tumors. Since 2005, he is the research group leader at the Institute of Biomedical Optics (BMO), University of Lübeck. Together with Eva Lankenau, he started the base research and development of iOCT at the BMO. His main research interests are now in photothermal and photochemical microeffects, optical coherence tomography, and multiphoton microscopy.
Abstract
The optical coherence tomography (OCT) is a non-invasive imaging technique, which recently has found important clinical micrometer applications. It allows noncontact and non-invasive cross-section imaging of the tissues with a depth resolution of about 10 µm. Similar to high-frequency ultrasound, the OCT shows real-time cross-sectional images of the tissue structures and tissue layers in a depth of a few millimeters. The OCT has evolved to an indispensable tool in ophthalmic diagnosis. An emerging application is the intraoperative use of OCT (iOCT). We developed the first commercially available device for the OCT, a universal OCT-Camera, which can be attached to the camera port of the different surgical microscopes. The OCT-Camera is completely integrated into the surgical procedure by enabling the OCT imaging before, during, and after microsurgery without interruption. The individual steps and the outcome of the surgical procedures, such as transplantation of the thin membranes or micro implants, are visualized in real time. The easy handling and first clinical applications of the iOCT were successfully demonstrated.
About the authors
Eva Maria Lankenau studied Physics at the University of Hamburg. In her Diploma Thesis, she analyzed the change of the temperature jump in protein mono-crystals under synchrotron and laser radiation experimentally. At the Medical Laser Center Luebeck, in cooperation with the University of Luebeck, she received her PhD for research and development in the field of optical coherence tomography (OCT). In her thesis, she analyzed and described the dispersion effects and applications in medical diagnosis with OCT. In 2009, she started her own project at the Institute of Biomedical Optics (BMO) at the University of Luebeck sponsored by the Federal Ministry BMWi (‘Exist-Forschungstransfer’), which enabled the formation of the company OptoMedical Technologies GmbH (OpMedT). Since 2010, she has been the Chief Executive Officer of the company that brings imaging and diagnostic methods such as optical coherence tomography to the new medical disciplines.
Marc Krug studied Physics at the University of Kassel. In his Diploma, he set up a velocity map imaging (VMI) spectrometer for investigations on the interaction of the ultrashort polarizationshaped femtosecond laser pulses with the alkali metal atoms. At the University of Kassel, he received his PhD for the measurements of the three-dimensional photoelectron angular distributions employing a novel tomographic reconstruction technique. In 2009, he joined the group of Dr. Eva Lankenau for preparing the foundation of the OptoMedical Technologies GmbH (OpMedT). Today, he is the Chief Operating Officer and Head of the R&D of OpMedT (Lübeck, Germany).
Stefan Oelckers studied Physics in Hamburg. In his Diploma, he was working on the medical applications of synchrotron radiation. His PhD and postdoc in Berlin were about photodynamic therapy, where he built up several spectroscopic setups and achieved the first optical detection of the ultra-weak singlet oxygen emission from the inside of the native biological membranes. At Moeller-Wedel, he does regular development and works on the new techniques for the surgical microscopes. He started the company’s cooperation with the BMO on OCT. After the completion of the government-funded BMO Project, Dr. Lankenau and he were very involved with the continuation of their visions that resulted in the foundation of the OptoMedical Technologies GmbH.
Norbert Schrage received his medical PhD in 1990 for the investigations of the severest acid burns of the corneas with scanning electron microscopy and X-ray structure analysis. In 1996, he received the board certification in Ophthalmology. With his habilitation in the field of chemical elements inside the cornea, he received his venia legendi in 1997. He is the chairman of the ACTO e.V. After he was Deputy Director of the Department of Ophthalmology in Aachen, he is now the Head of the Department of Ophthalmology in Cologne Merheim since 2004.
Tino Just studied Medicine at the University of Rostock in Germany. He received his MD from the University of Rostock in 1999. He finished his habilitation in 2006 and received the permission for lecturing (facultas docendi) in 2007. In 2003, he received the board certification in Otorhinolaryngology. Dr. Just is a fully trained surgeon in the field of otorhinolaryngology with specialties in ear surgery (cochlear implant, implantable hearing aids), plastic surgery, and laryngeal surgery. Today, he is the Senior Consultant and Deputy Director of the Department of Otorhinolaryngology in Rostock.
Gereon Hüttmann received, in 1988, the Master of Science degree in Physics and, in 1992, his PhD in Physical Chemistry from the University of Göttingen. From 1992 to 2005, he is a research member of the Medical Laser Center in Lübeck, Germany, working in the fields of photodynamic therapy and fluorescence detection of tumors. Since 2005, he is the research group leader at the Institute of Biomedical Optics (BMO), University of Lübeck. Together with Eva Lankenau, he started the base research and development of iOCT at the BMO. His main research interests are now in photothermal and photochemical microeffects, optical coherence tomography, and multiphoton microscopy.
The base technology of the OCT-Camera was developed at the Institute of Biomedical Optics (BMO) at the University of Luebeck in cooperation with Moeller-Wedel GmbH. The OptoMedical Technologies GmbH was formed in 2010 as a spin-off company of the BMO. Supported of the Federal Government (BMWi), Exist Forschungstransfer, Hochschule-Wirtschaft-Transfer, is gratefully acknowledged.
References
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©2013 by THOSS Media & De Gruyter Berlin Boston
Artikel in diesem Heft
- Masthead
- Masthead
- Community
- News from the European Optical Society
- Conference Notes
- Conference Calendar
- SMETHODS: Free courses on optical design
- Topical Issue: Microscopy Technologies
- Editorial
- New microscopes push the limits of far field microscopy
- Review Article
- Super-resolution microscopy heads towards 3D dynamics
- Research Articles
- iOCT with surgical microscopes: a new imaging during microsurgery
- High-resolution InGaAs sensor pushing biomedical infrared optical coherence tomography
- Tutorial
- Physical optics methods for laser and nonlinear optics simulations
- Research Articles
- Manufacturing of a precision 3D microlens array on a steep curved substrate by injection molding process
- Aspherical plastic lens injection molding warpage and opto-mechanical analysis
Artikel in diesem Heft
- Masthead
- Masthead
- Community
- News from the European Optical Society
- Conference Notes
- Conference Calendar
- SMETHODS: Free courses on optical design
- Topical Issue: Microscopy Technologies
- Editorial
- New microscopes push the limits of far field microscopy
- Review Article
- Super-resolution microscopy heads towards 3D dynamics
- Research Articles
- iOCT with surgical microscopes: a new imaging during microsurgery
- High-resolution InGaAs sensor pushing biomedical infrared optical coherence tomography
- Tutorial
- Physical optics methods for laser and nonlinear optics simulations
- Research Articles
- Manufacturing of a precision 3D microlens array on a steep curved substrate by injection molding process
- Aspherical plastic lens injection molding warpage and opto-mechanical analysis
