High cytomegalovirus IgG avidity is a reliable indicator of past infection in patients with positive IgM detected during the first trimester of pregnancy
-
Bibi Kanengisser-Pines
Abstract
Objective: To evaluate the accuracy of high cytomegalovirus (CMV) specific IgG avidity in excluding recent infection in patients with anti-CMV IgM antibodies detected during the first trimester, using amniotic fluid obtained by standard amniocentesis.
Methods: Records of all patients with a positive anti-CMV IgM with IgG avidity >65% detected during pregnancy were reviewed. Amniocentesis for CMV assessment was offered to all patients. The presence of the virus in amniotic fluid was determined by polymerase chain reaction (PCR) and shell vial testing.
Results: Seventy-nine patients with a positive CMV IgM-high IgG avidity combination were identified. The serological tests were performed during the first trimester in 65 (82.3%) patients, of which 28 consented and underwent amniocentesis. All amniotic fluid samples were negative for CMV-PCR and CMV shell vial testing.
Conclusions: IgG avidity above 65% is a good indicator of past infection, and thus excludes CMV in the amniotic fluid. In such circumstances, invasive prenatal diagnosis may eventually not be required. This optimistic conclusion, however, needs to be confirmed by large scale studies.
©2009 by Walter de Gruyter Berlin New York
Articles in the same Issue
- Recommendations and guidelines for perinatal practice
- Perinatal echocardiography: protocols for evaluating the fetal and neonatal heart
- Review article
- Progestational agents for the prevention of preterm birth
- Original articles – Obstetrics
- High cytomegalovirus IgG avidity is a reliable indicator of past infection in patients with positive IgM detected during the first trimester of pregnancy
- Erythrocyte changes in preeclampsia: relationship between maternal and cord blood erythrocyte damage
- Amniotic fluid adhesion molecules during parturition at term
- Serum levels of adenosine deaminase and pregnancy-related hormones in hyperemesis gravidarum
- Association between von Willebrand factor gene polymorphism and preeclampsia
- The effect of the 2004 Italian legislation on perinatal outcomes following assisted reproduction technology
- Original article – Fetus
- Growth deficit in term small-for-gestational fetuses with normal umbilical artery Doppler is associated with adverse outcome
- Evidence to support that spontaneous preterm labor is adaptive in nature: neonatal RDS is more common in “indicated” than in “spontaneous” preterm birth
- Changes in β1 integrin in renal tubular epithelial cells after intrauterine asphyxia of rabbit pups
- Correlation between the presence of liver herniation and perinatal outcome in prenatally diagnosed fetal omphalocele
- Original articles – Newborn
- Intrauterine infection with Ureaplasma species is associated with adverse neuromotor outcome at 1 and 2 years adjusted age in preterm infants
- A role of end-tidal CO2 monitoring for assessment of tracheal intubations in very low birth weight infants during neonatal resuscitation at birth
- Short communication
- Selective feticide in dichorionic pregnancies with intracardiac blood aspiration: report of nine cases
- National screening program vs. standardized neurodevelopmental follow-up
- Roster of Perinatal Societies
- Roster of Perinatal Societies
- Congress Calendar
- Congress Calendar
- Erratum
- Long-term epidural block treatment in patients with early threatening preterm delivery and vaginal fetal engagement
Articles in the same Issue
- Recommendations and guidelines for perinatal practice
- Perinatal echocardiography: protocols for evaluating the fetal and neonatal heart
- Review article
- Progestational agents for the prevention of preterm birth
- Original articles – Obstetrics
- High cytomegalovirus IgG avidity is a reliable indicator of past infection in patients with positive IgM detected during the first trimester of pregnancy
- Erythrocyte changes in preeclampsia: relationship between maternal and cord blood erythrocyte damage
- Amniotic fluid adhesion molecules during parturition at term
- Serum levels of adenosine deaminase and pregnancy-related hormones in hyperemesis gravidarum
- Association between von Willebrand factor gene polymorphism and preeclampsia
- The effect of the 2004 Italian legislation on perinatal outcomes following assisted reproduction technology
- Original article – Fetus
- Growth deficit in term small-for-gestational fetuses with normal umbilical artery Doppler is associated with adverse outcome
- Evidence to support that spontaneous preterm labor is adaptive in nature: neonatal RDS is more common in “indicated” than in “spontaneous” preterm birth
- Changes in β1 integrin in renal tubular epithelial cells after intrauterine asphyxia of rabbit pups
- Correlation between the presence of liver herniation and perinatal outcome in prenatally diagnosed fetal omphalocele
- Original articles – Newborn
- Intrauterine infection with Ureaplasma species is associated with adverse neuromotor outcome at 1 and 2 years adjusted age in preterm infants
- A role of end-tidal CO2 monitoring for assessment of tracheal intubations in very low birth weight infants during neonatal resuscitation at birth
- Short communication
- Selective feticide in dichorionic pregnancies with intracardiac blood aspiration: report of nine cases
- National screening program vs. standardized neurodevelopmental follow-up
- Roster of Perinatal Societies
- Roster of Perinatal Societies
- Congress Calendar
- Congress Calendar
- Erratum
- Long-term epidural block treatment in patients with early threatening preterm delivery and vaginal fetal engagement
