Bronchopulmonary dysplasia and early prophylactic inhaled nitric oxide in preterm infants: current concepts and future research strategies in animal models
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Esther Rieger-Fackeldey
Abstract
We reviewed the literature on the use of inhaled nitric oxide and the influence of supplemental oxygen on bronchopulmonary dysplasia (BPD), and the role of endogenous nitric oxide-synthase, vascular endothelial growth factor, the interplay of nitric oxide and superoxide, protein nitration and the nuclear factor kappa B-pathway. BPD is a major cause of neonatal mortality and morbidity leading to arrested lung development in newborns. Several studies indicate that inhaled nitric oxide (iNO) improves pulmonary angiogenesis, lung alveolarization, distal lung growth and pulmonary function in preterm infants. Given the inconclusive results of clinical studies, however, it is unclear which subpopulations of infants might benefit. Moreover, data on iNO are conflicting whether exogenous nitric oxide is protective or damaging in the presence of hyperoxia. The toxicology of iNO is poorly understood and its potential interaction with oxygen has to be considered given that infants treated with iNO are also supplemented with oxygen. The underlying mechanisms of the effects of iNO in the newborn lung need further analysis. New data clarifying the role of endogenous nitric oxide-synthases, vascular endothelial growth factor (VEGF), the interplay of nitric oxide and superoxide, and protein nitration with concurrent iNO-therapy might answer some of these questions.
©2008 by Walter de Gruyter Berlin New York
Artikel in diesem Heft
- Original articles – Obstetrics
- Premature labor: a state of platelet activation?
- Soluble receptor for advanced glycation end products (sRAGE) and endogenous secretory RAGE (esRAGE) in amniotic fluid: modulation by infection and inflammation
- Detection of feto-maternal infection/inflammation by the soluble receptor for advanced glycation end products (sRAGE): results of a pilot study
- Weight gain in pregnancy according to maternal height and weight
- A randomized trial of tight vs. less tight control of mild essential and gestational hypertension in pregnancy
- Pregnancy outcome of women who developed proteinuria in the absence of hypertension after mid-gestation
- Anxiety symptoms during late pregnancy and early parenthood following assisted reproductive technology
- Original article – Fetus
- Human fetal heart rate variability-characteristics of autonomic regulation in the third trimester of gestation
- Original articles – Newborn
- Bronchopulmonary dysplasia and early prophylactic inhaled nitric oxide in preterm infants: current concepts and future research strategies in animal models
- Side effects of angiotensin converting enzyme inhibitor (captopril) in newborns and young infants
- Letters to the editor
- Mirror syndrome due to coxackie B virus associated to maternal peripartum cardiomyopathy
- Non-cardiogenic lung edema in a woman treated with atosiban for preterm labor
- Commentary: A case of non-cardiogenic lung edema in a woman treated with atosiban for preterm labor
- Congress Calendar
- 10.1515/JPM.2008.095
- Erratum
- Total body water in small- and appropriate - for gestational age newborns
- Announcement
- Calling European Pediatric Research Networks
- WAPM-Newsletter
- WAPM-Newsletter No 1/2008
Artikel in diesem Heft
- Original articles – Obstetrics
- Premature labor: a state of platelet activation?
- Soluble receptor for advanced glycation end products (sRAGE) and endogenous secretory RAGE (esRAGE) in amniotic fluid: modulation by infection and inflammation
- Detection of feto-maternal infection/inflammation by the soluble receptor for advanced glycation end products (sRAGE): results of a pilot study
- Weight gain in pregnancy according to maternal height and weight
- A randomized trial of tight vs. less tight control of mild essential and gestational hypertension in pregnancy
- Pregnancy outcome of women who developed proteinuria in the absence of hypertension after mid-gestation
- Anxiety symptoms during late pregnancy and early parenthood following assisted reproductive technology
- Original article – Fetus
- Human fetal heart rate variability-characteristics of autonomic regulation in the third trimester of gestation
- Original articles – Newborn
- Bronchopulmonary dysplasia and early prophylactic inhaled nitric oxide in preterm infants: current concepts and future research strategies in animal models
- Side effects of angiotensin converting enzyme inhibitor (captopril) in newborns and young infants
- Letters to the editor
- Mirror syndrome due to coxackie B virus associated to maternal peripartum cardiomyopathy
- Non-cardiogenic lung edema in a woman treated with atosiban for preterm labor
- Commentary: A case of non-cardiogenic lung edema in a woman treated with atosiban for preterm labor
- Congress Calendar
- 10.1515/JPM.2008.095
- Erratum
- Total body water in small- and appropriate - for gestational age newborns
- Announcement
- Calling European Pediatric Research Networks
- WAPM-Newsletter
- WAPM-Newsletter No 1/2008
