Post-delivery oxidative stress in women with preeclampsia or IUGR
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Patricia Kressig
Abstract
Aim: To compare oxidative stress in patients with preeclampsia (PE) or intrauterine growth restriction (IUGR) vs. normal pregnancy (controls) during 48 h after delivery.
Study design: Women with singleton pregnancies were recruited immediately after delivery (gestational age >26.0 weeks). Women with PE or IUGR were matched with healthy controls by age, BMI, gestational age and delivery mode. Venous blood samples and urine samples were tested for oxidative stress products 24 h and 48 h after delivery.
Results: Plasma malondialdehyde (MDA) concentration 24 h after delivery was significantly higher in subjects with PE or IUGR (3.41±1.14 μmol/L, n=20) than in controls (2.91±0.82 μmol/L, n=38) (P=0.04). Urine iPF2α-VI declined from 24 to 48 h after delivery significantly in controls (P=0.006) and not in subjects with PE or IUGR (P=0.71).
Conclusion: Of the markers tested only MDA is indicating higher oxidative stress in women with PE/IUGR than in normal pregnancy and only at 24 h after delivery. No consistent pattern of change in the oxidative stress markers exists between 24–48 h after delivery.
©2008 by Walter de Gruyter Berlin New York
Articles in the same Issue
- Editorial
- Does globalization and change demand a different kind of perinatal research?
- Recommendations and guidelines for perinatal practice
- Intrauterine restriction (IUGR)
- Review article
- The role of antioxidant vitamins in hypertensive disorders of pregnancy
- Original articles – Obstetrics
- The fetus, not the mother, elicits maternal immunologic rejection: lessons from discordant dizygotic twin placentas
- Do risk factors for elective cesarean section differ from those of cesarean section during labor in low risk pregnancies?
- Obstetric antecedents for preterm delivery
- Post-delivery oxidative stress in women with preeclampsia or IUGR
- Evidence supporting proteolytic cleavage of insulin-like growth factor binding protein-1 (IGFBP-1) protein in amniotic fluid
- Original articles – Fetus
- Value of a single early third trimester fetal biometry for the prediction of birth weight deviations in a low risk population
- Comparison of six sonographic signs in the prenatal diagnosis of spina bifida
- Original articles – Newborn
- Relationships between umbilical cord arterial blood pH levels at delivery and Bayley Psychomotor Development Index scores in early childhood
- Head circumference and long-term outcome in small-for-gestational age infants
- Hypocalcemia is common in the first 48 h of life in ELBW infants
- Total body water in small- and appropriate- for gestational age newborns
- Below median birth weight in appropriate-for-gestational-age preterm infants as a risk factor for bronchopulmonary dysplasia
- Letter to the editor
- Congenital lupus erythematosus affecting both twins
- Obituary Gösta Rooth
- The death of Prof. Gösta Rooth
- Erratum
- Hematological profile of Korean very low birth weight infants
- Congress Calander
- Congress Calendar
- Announcement
- Announcement
Articles in the same Issue
- Editorial
- Does globalization and change demand a different kind of perinatal research?
- Recommendations and guidelines for perinatal practice
- Intrauterine restriction (IUGR)
- Review article
- The role of antioxidant vitamins in hypertensive disorders of pregnancy
- Original articles – Obstetrics
- The fetus, not the mother, elicits maternal immunologic rejection: lessons from discordant dizygotic twin placentas
- Do risk factors for elective cesarean section differ from those of cesarean section during labor in low risk pregnancies?
- Obstetric antecedents for preterm delivery
- Post-delivery oxidative stress in women with preeclampsia or IUGR
- Evidence supporting proteolytic cleavage of insulin-like growth factor binding protein-1 (IGFBP-1) protein in amniotic fluid
- Original articles – Fetus
- Value of a single early third trimester fetal biometry for the prediction of birth weight deviations in a low risk population
- Comparison of six sonographic signs in the prenatal diagnosis of spina bifida
- Original articles – Newborn
- Relationships between umbilical cord arterial blood pH levels at delivery and Bayley Psychomotor Development Index scores in early childhood
- Head circumference and long-term outcome in small-for-gestational age infants
- Hypocalcemia is common in the first 48 h of life in ELBW infants
- Total body water in small- and appropriate- for gestational age newborns
- Below median birth weight in appropriate-for-gestational-age preterm infants as a risk factor for bronchopulmonary dysplasia
- Letter to the editor
- Congenital lupus erythematosus affecting both twins
- Obituary Gösta Rooth
- The death of Prof. Gösta Rooth
- Erratum
- Hematological profile of Korean very low birth weight infants
- Congress Calander
- Congress Calendar
- Announcement
- Announcement
