Mortality and morbidity of neonates born at <26 weeks of gestation (1998–2003). A population-based study
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Eva Landmann
Abstract
Objective: To describe mortality and morbidity of neonates born at <26 weeks' gestation in a contemporary population-based cohort.
Methods: We analyzed data of neonates born at <26 weeks between 1998 and 2003 in the Federal State of Hesse, Germany. Survival was calculated at 28 days and at discharge from hospital.
Results: Out of a total of 800 births, 572 infants were liveborn. Among those admitted for neonatal intensive care, 62.3% survived until day 28. Among the neonates followed until death or discharge, 59.6% were discharged home. Logistic regression analyses showed the following variables to be associated with an increased risk of death: Twins (Odds Ratio (OR) 3.7; 95% Confidence Interval (CI) 1.34–10.26), multiple birth ≥3 (OR 8.14; CI 1.23–53.86), intraventricular hemorrhage (IVH) ≥grade III (OR 4.79; CI 1.89–12.14), clinical risk index for babies score >15 (OR 2.9; CI 1.09–7.76), and a gestational age ≤23 weeks (OR 5.34; CI 1.24–22.98). Among infants discharged home, bronchopulmonary dysplasia was diagnosed in 52.2%, IVH ≥grade III and/or periventricular leukomalacia in 15%, and severe retinopathy of prematurity in 29.8%.
Conclusions: This study provides outcome data derived from a contemporary population-based cohort. Mortality and complication rates remain high.
©2008 by Walter de Gruyter Berlin New York
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- Prenatal long-chain polyunsaturated fatty acid status: the importance of a balanced intake of docosahexaenoic acid and arachidonic acid
- Population-based standardization (PBS) of institutional cesarean delivery rates
- Impact of high maternal hemoglobin at first antenatal visit on pregnancy outcomes: a cohort study
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- The association between maternal characteristics and different types and levels of discordance in triplet pregnancies
- Obstetric gel shortens second stage of labor and prevents perineal trauma in nulliparous women: a randomized controlled trial on labor facilitation
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- 17-Hydroxyprogesterone in premature infants as a marker of intrauterine stress
- Prenatal hypoxia preconditioning improves hypoxic ventilatory response and reduces mortality in neonatal rats
- Mortality and morbidity of neonates born at <26 weeks of gestation (1998–2003). A population-based study
- Conception without the development of a human being
- Intraplacental choriocarcinoma with fetomaternal hemorrhage: a case study and literature review
- Computerized FHR traces in post-term pregnancies
- Uterine activity monitoring during labor
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