Genes and the preeclampsia syndrome
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Sabine Mütze
Abstract
Preeclampsia is specific to pregnancy and is still a leading cause of maternal and perinatal mortality and morbidity, affecting about 3% of women, but the underlying pathogenetic mechanisms still remain unclear. Immune maladaptation, placental ischemia and increased oxidative stress represent the main components discussed to be of etiologic importance, and they all may have genetic implications. Since the familial nature of preeclampsia is known for many years, extensive research on the genetic contribution to the pathogenesis of this severe pregnancy disorder has been performed. In this review, we will overview the linkage and candidate gene studies carried out so far as well as summarize important historical notes on the genetic hypotheses generated in preeclampsia research. Moreover, the influence of maternal and fetal genes and their interaction as well as the role of genomic imprinting in preeclampsia will be discussed.
©2008 by Walter de Gruyter Berlin New York
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- Roster of Perinatal Societies
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Articles in the same Issue
- The roles of long-chain polyunsaturated fatty acids in pregnancy, lactation and infancy: review of current knowledge and consensus recommendations
- Treatment and prevention of malaria in pregnancy and newborn
- Uterine activity: implications for the condition of the fetus
- Genes and the preeclampsia syndrome
- Correlation between ultrasound and autopsy findings after 2nd trimester terminations of pregnancy
- Illegal drug use, smoking and alcohol consumption in a low-risk Irish primigravid population
- New scoring system for fetal neurobehavior assessed by three- and four-dimensional sonography
- Fetal extremity kinetics quantified with Doppler ultrasonography
- Quantification of impulse experienced by neonates during inter- and intra-hospital transport measured by biophysical accelerometery
- Roster of Perinatal Societies
- Congress Calendar
