Association between peak serum bilirubin and severity of respiratory distress syndrome in infants of less than 30 weeks' gestation
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Carlo Dani
Abstract
Introduction: Bilirubin can enter the alveolar space where it could inactivate surfactant and act as an anti-oxidant agent.
Objective: To assess the hypothesis that total serum bilirubin level (TSB) may affect the severity of respiratory distress syndrome (RDS) and the need of respiratory supports in preterm infants.
Study design: We performed a retrospective study of 184 preterm infants with RDS, whose peak TSB had a median value of 194.8 μmol/L (=11.3 mg/dL). This value was used to stratify patients into two groups: neonates who developed low and high TSB (≤ or >194.8μmol/L, respectively). For each patient the highest values of inspired oxygen fraction (FiO2), arterial to alveolar oxygen tension ratio (a/APO2), oxygenation index (O.I.), ventilatory index (V.I.), and the need and duration of respiratory supports were recorded.
Results: Seventy-five infants were included in the low TSB group and 74 were included in the high TSB group. The RDS severity and the need of respiratory supports were similar in both the groups. The first day of life TSB and peak TSB did not correlate with the highest values of FiO2 and a/APO2, and the duration of mechanical ventilation.
Conclusions: We did not find any correlation between TSB level and RDS severity. We speculate that this result is because the potential inhibiting effect of bilirubin on surfactant function is neutralized by the exogenous surfactant treatment, while its antioxidant effects do not provide appreciable benefits in the lung tissue.
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©2007 by Walter de Gruyter Berlin New York
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Artikel in diesem Heft
- To all readers, authors and subscribers
- The relationship between periodontal disease, bacterial vaginosis, and preterm birth
- Does raising the glucose challenge test threshold impact birthweight in Asian gravidas?
- Puerperal complications following elective cesarean sections for twin pregnancies
- Fortified mineral water improves folate status and decreases plasma homocysteine concentration in pregnant women
- Milk iron content in breast-feeding mothers after administration of intravenous iron sucrose complex
- Uteroplacental circulation, preeclampsia, and maternal abdominal aortic stiffness in normal and compromised pregnancies
- Induction of labor with oral misoprostol for premature rupture of membranes at term in women with unfavorable cervix: a randomized, double-blind, placebo-controlled trial
- Reference intervals for the cross sectional area of the umbilical cord during gestation
- The combined effect of betamethasone and ritodrine on the middle cerebral artery in low risk third trimester pregnancies
- Association between peak serum bilirubin and severity of respiratory distress syndrome in infants of less than 30 weeks' gestation
- Ranitidine and late-onset sepsis in the neonatal intensive care unit
- Outcome of infants born at 21–28 weeks' gestation in an inner-city hospital over an eight-year period
- Detection rate of Helicobacter pylori stool antigen in newborn infants and small children
- The potential role of high or low birthweight as risk factor for adult schizophrenia
- Multiple vascular accidents: Pentalogy of Cantrell in one twin with left sided colonic atresia in the second twin
- Solitary hepatic lymphangioma in an infant
- Spontaneous twin pregnancy in a 56-year-old primipara
- Fetal behavior analyzed by ultrasonic actocardiogram in cases with central nervous system lesions
- Congress Calendar
