The association between maternal cervicovaginal proinflammatory cytokines concentrations during pregnancy and subsequent early-onset neonatal infection
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Jarosław Kalinka
Abstract
Objective: The aim of this study was to investigate the relationship between the concentration of selected proinflammatory cytokines (IL-1α, IL-1β, IL-6 and IL-8) in cervicovaginal fluid, as measured in midgestation, and the risk of early-onset neonatal infection (EONI).
Method: Cervicovaginal fluids were obtained from a cohort of 114 pregnant women at 22 to 34 weeks' gestation. The samples were analyzed for the concentrations of selected proinflammatory cytokines using standard enzyme-linked immunosorbent assay technique (ELISA). Lower genital tract microbiology was diagnosed using Gram stain method according to Spiegel's criteria and by culture.
Results: Mean gestational age at the time of sampling was 29.0 weeks. Mean time between sampling and delivery was 9.3 (SD 4.7) weeks. Bacterial vaginosis (BV) was diagnosed in 27.2% of subjects and M. hominis and U. urealyticum in 22.8% and 26.3%, respectively. Out of 114 women examined, 20 (17.5%) delivered newborns with EONI. Median cervicovaginal concentrations of IL-1α, IL-1β, IL-6 and IL-8 did not differ between women who delivered newborns with EONI as compared to women who delivered newborns without EONI. Women with pathological lower genital tract microflora and low IL-8 concentration (below 25th percentile) during pregnancy presented a significant risk of delivering newborns with EONI (OR=4.9; 95% CI, 1.1–22.8). Subjects with pathological lower genital tract microflora and a low concentration of more than one cytokine had the highest risk of delivering a newborn with EONI, OR=16.2, 95% CI, 1.1–234.0.
Conclusions: Cytokine measurement in cervicovaginal fluid in early gestation could be useful for predicting subsequent EONI only among pregnant women with lower genital tract infection. Maternal genital tract immune hyporesponsiveness as represented by low concentrations of proinflammatory cytokines may create a permissive environment for ascending infection and may lead to subsequent EONI.
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©2006 by Walter de Gruyter Berlin New York
Articles in the same Issue
- Non-selective fetal reduction is malpractice
- Guidelines for the management of spontaneous preterm labor
- Accuracy of second trimester fetal head circumference and biparietal diameter for predicting the time of spontaneous birth
- The association between maternal cervicovaginal proinflammatory cytokines concentrations during pregnancy and subsequent early-onset neonatal infection
- Leukocytosis might precede in-hospital eclampsia in preeclamptic women who do not receive magnesium sulfate
- Randomized prospective comparative study of ursodeoxycholic acid and S-adenosyl-L-methionine in the treatment of intrahepatic cholestasis of pregnancy
- Coagulation-fibrinolysis is more enhanced in twin than in singleton pregnancies
- Fetal behavior analyzed by ultrasonic actocardiogram in cases with central nervous system lesions
- Early weight gain does not decrease the incidence of low birth weight and small for gestational age triplets in mothers with normal pre-gestational body mass index
- Umbilical artery pulsatility index: reliability at different sampling sites
- Inferior vena cava diameter pulse waveforms in the human fetus: relationship with flow velocity waveform
- A trial of preventing early- and late-onset Group B streptococcal sepsis with combined intrapartum chemoprophylaxis and universal neonatal screening
- Impact of prenatal urinomas in patients with posterior urethral valves and postnatal renal function
- Congress Calendar
Articles in the same Issue
- Non-selective fetal reduction is malpractice
- Guidelines for the management of spontaneous preterm labor
- Accuracy of second trimester fetal head circumference and biparietal diameter for predicting the time of spontaneous birth
- The association between maternal cervicovaginal proinflammatory cytokines concentrations during pregnancy and subsequent early-onset neonatal infection
- Leukocytosis might precede in-hospital eclampsia in preeclamptic women who do not receive magnesium sulfate
- Randomized prospective comparative study of ursodeoxycholic acid and S-adenosyl-L-methionine in the treatment of intrahepatic cholestasis of pregnancy
- Coagulation-fibrinolysis is more enhanced in twin than in singleton pregnancies
- Fetal behavior analyzed by ultrasonic actocardiogram in cases with central nervous system lesions
- Early weight gain does not decrease the incidence of low birth weight and small for gestational age triplets in mothers with normal pre-gestational body mass index
- Umbilical artery pulsatility index: reliability at different sampling sites
- Inferior vena cava diameter pulse waveforms in the human fetus: relationship with flow velocity waveform
- A trial of preventing early- and late-onset Group B streptococcal sepsis with combined intrapartum chemoprophylaxis and universal neonatal screening
- Impact of prenatal urinomas in patients with posterior urethral valves and postnatal renal function
- Congress Calendar
