Perinatal outcomes of spontaneous twins compared with twins conceived through intracytoplasmic sperm injection
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Burcu Saygan-Karamürsel
Abstract
Objective: To compare perinatal outcomes in spontaneous twins compared with those conceived by intracytoplasmic sperm injection (ICSI).
Design: Retrospective case-control study.
Patients: Cases consisted of 274 intracytoplasmic sperm injection twins, controls were 348 naturally conceived twins delivered between 1999 and 2003 in a tertiary hospital.
Main outcome measures: Birth weight, gestational age at birth, cesarean delivery rate, perinatal mortality and morbidity, congenital anomalies, gestational diabetes and pregnancy induced hypertension.
Results: Preterm deliveries (76.6% vs. 64.1% <37 weeks and 19.7% vs. 13.2% <32 weeks) and low birth weight (73% vs. 60.3% <2500 g and 19.7% vs. 12.6% <1500 g) were significantly higher in the ICSI group compared with controls. Gestational diabetes mellitus (8% vs. 2.9%) and cesarean deliveries (95.2% vs. 77.6%) were more common in cases compared with the control group. There was a significantly higher rate of perinatal morbidity (16.4% vs. 7.8%) and mortality (8% vs. 2.6%) in ICSI twins. The incidence of congenital malformations diagnosed at birth was higher in cases (4.4%) compared with controls (0.9%) but the difference was not significant when adjusted for maternal age.
Conclusion: Perinatal outcomes of twins after ICSI treatment are less optimal than naturally conceived twins.
References
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Articles in the same Issue
- Intrapartum fetal monitoring today
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- Induction of labor with oral misoprostol in nulliparous mothers of twins
- Is the nausea and vomiting of early pregnancy really feto-protective?
- Tele-virtual sonography
- The effect of betamethasone administration on uterine motility in pregnancy. A prospective study using four-channel tocography
- Perinatal outcomes of spontaneous twins compared with twins conceived through intracytoplasmic sperm injection
- Doppler sonography of the uterine and the cubital arteries in normal pregnancies, preeclampsia and intrauterine growth restriction: evidence for a systemic vessel involvement
- The efficacy of first-trimester PAPP-A and free βhCG levels for predicting adverse pregnancy outcome
- Sonographic monitoring of systemic and local methotrexate (MTX) therapy in patients with intact interstitial pregnancies
- The Northwestern twin chorionicity study: testing the ‘placental crowding’ hypothesis
- Combined first trimester screening for trisomy 21: lack of agreement between risk calculation methods
- Neonatal septicemia in high risk babies in South-Eastern Nigeria
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- Antenatal diagnosis of velocardiofacial syndrome by 3D ultrasonography
- Congress Calendar
Articles in the same Issue
- Intrapartum fetal monitoring today
- Placental Doppler velocimetry in gestational diabetes mellitus
- Induction of labor with oral misoprostol in nulliparous mothers of twins
- Is the nausea and vomiting of early pregnancy really feto-protective?
- Tele-virtual sonography
- The effect of betamethasone administration on uterine motility in pregnancy. A prospective study using four-channel tocography
- Perinatal outcomes of spontaneous twins compared with twins conceived through intracytoplasmic sperm injection
- Doppler sonography of the uterine and the cubital arteries in normal pregnancies, preeclampsia and intrauterine growth restriction: evidence for a systemic vessel involvement
- The efficacy of first-trimester PAPP-A and free βhCG levels for predicting adverse pregnancy outcome
- Sonographic monitoring of systemic and local methotrexate (MTX) therapy in patients with intact interstitial pregnancies
- The Northwestern twin chorionicity study: testing the ‘placental crowding’ hypothesis
- Combined first trimester screening for trisomy 21: lack of agreement between risk calculation methods
- Neonatal septicemia in high risk babies in South-Eastern Nigeria
- Maternal antenatal administration of vitamin K1 results in increasing the activities of vitamin K-dependent coagulation factors in umbilical blood and in decreasing the incidence rate of periventricular-intraventricular hemorrhage in premature infants
- Antenatal diagnosis of velocardiofacial syndrome by 3D ultrasonography
- Congress Calendar