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Perinatal outcomes of spontaneous twins compared with twins conceived through intracytoplasmic sperm injection

  • Burcu Saygan-Karamürsel , Özlem Tekşam , Tarık Aksu , Murat Yurdakök and Lütfü Önderoğlu
Published/Copyright: March 7, 2006
Journal of Perinatal Medicine
From the journal Volume 34 Issue 2

Abstract

Objective: To compare perinatal outcomes in spontaneous twins compared with those conceived by intracytoplasmic sperm injection (ICSI).

Design: Retrospective case-control study.

Patients: Cases consisted of 274 intracytoplasmic sperm injection twins, controls were 348 naturally conceived twins delivered between 1999 and 2003 in a tertiary hospital.

Main outcome measures: Birth weight, gestational age at birth, cesarean delivery rate, perinatal mortality and morbidity, congenital anomalies, gestational diabetes and pregnancy induced hypertension.

Results: Preterm deliveries (76.6% vs. 64.1% <37 weeks and 19.7% vs. 13.2% <32 weeks) and low birth weight (73% vs. 60.3% <2500 g and 19.7% vs. 12.6% <1500 g) were significantly higher in the ICSI group compared with controls. Gestational diabetes mellitus (8% vs. 2.9%) and cesarean deliveries (95.2% vs. 77.6%) were more common in cases compared with the control group. There was a significantly higher rate of perinatal morbidity (16.4% vs. 7.8%) and mortality (8% vs. 2.6%) in ICSI twins. The incidence of congenital malformations diagnosed at birth was higher in cases (4.4%) compared with controls (0.9%) but the difference was not significant when adjusted for maternal age.

Conclusion: Perinatal outcomes of twins after ICSI treatment are less optimal than naturally conceived twins.

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Corresponding author: Burcu Saygan-Karamürsel, Kenedi Cad, 111/23 GOP, Ankara, Turkey Tel.: +90-532-4336003

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Published Online: 2006-03-07
Published in Print: 2006-04-01

©2005 by Walter de Gruyter Berlin New York

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