The association of birthweight with maternal and cord serum and amniotic fluid growth hormone and insulin levels, and with neonatal and maternal factors in pregnant women who delivered at term
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Abstract
Aim: To investigate the influence of maternal and cord serum and amniotic fluid growth hormone (GH) and insulin and other neonatal and maternal factors on birthweight.
Methods: A total of 160 pregnant women at 38–42 weeks' gestation were studied. All infants were categorized as small for gestational age (SGA) (n = 50), large for gestational age (LGA) (n = 50) or average for gestational age (AGA) (n = 60). GH and insulin levels were measured in maternal and cord serum and amniotic fluid at birth.
Results: GH levels in maternal and cord serum and amniotic fluid showed no differences among the three weight groups (P > 0.05). The cord insulin level was significantly lower in SGA (P < 0.01). The insulin level in venous cord blood correlated with birth and placental weights and neonatal height, whereas maternal serum and amniotic fluid insulin levels, and maternal and cord serum and amniotic fluid GH levels did not show any correlation with birthweight. The cord GH level at birth was correlated with GH levels after 4 postnatal weeks in the SGA group (P < 0.01). In addition, birthweight showed a correlation with prepartum maternal weight, maternal weight gain, maternal height, neonatal length and placental weight in all three weight groups.
Conclusions: Cord GH, maternal serum and amniotic fluid GH and insulin levels did not correlate with birthweight in all three weight groups. The lack of correlation for GH levels in maternal and cord serum and amniotic fluid suggests that these compartments may be noncommunicating separate units.
References
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Articles in the same Issue
- Fetal cardiovascular response to large placental chorioangiomas
- Characteristics of mothers who delivered the heaviest, average-weight, and lightest triplet sets
- Amniotic fluid concentrations of collagenase-1 and collagenase-3 are increased in polyhydramnios
- Oxytocic activity of thrombin: modulation of thrombin-induced gravid rat myometrial contractions by 5-hydroxytryptamine receptor antagonists
- Structural-tridimensional study of yolk sac in pregnancies complicated by diabetes
- Is cervical dilatation during parturition at term associated with apoptosis?
- Amnioreduction in patients with bulging prolapsed membranes out of the cervix and vaginal orifice in cervical cerclage
- The association of birthweight with maternal and cord serum and amniotic fluid growth hormone and insulin levels, and with neonatal and maternal factors in pregnant women who delivered at term
- Ultrasonographic fetal weight estimation: accuracy of formulas and accuracy of examiners by birth weight from 500 to 5000 g
- Atypical chronic lung disease in preterm infants
- Clinical characteristics and follow up of Down syndrome infants without congenital heart disease who presented with persistent pulmonary hypertension of newborn
- Mortality and long term morbidity in esophageal atresia: the reduced impact of low birth weight and maturity on surgical outcome
- Non-hydropic intrauterine fetal death more than five months after primary parvovirus B19 infection
- HELLP syndrome, multifactorial thrombophilia and postpartum myocardial infarction
- Management of cervical pregnancy: risk factors for failed systemic methotrexate
- Autologous cord blood transfusion in an infant with a huge sacrococcygeal teratoma
- Intussusception in a preterm neonate; a very rare, major intestinal problem – systematic review of cases
- Book review