Microbial invasion of the amniotic cavity at birth is associated with adverse short-term outcome of preterm infants
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A. Berger
Abstract
Aims: To determine the frequency and clinical significance of microbial invasion of the amniotic cavity at the time of delivery in preterm infants.
Methods: Prospective cohort study during June 2001 and January 2002. Preterm infants < 33+6 weeks of gestation who had amniotic fluid and placental tissue sampled for culture during cesarean section were included.
Results: Of a total of 80 neonates, 42 had negative culture results, 22 had growth of Ureaplasma urealyticum, and 16 had growth of other pathogens. Isolation of Ureaplasma urealyticum was associated with a decreased risk of developing hyaline membrane disease after birth but a more than 20 times increased risk of developing chronic lung disease. Patients with growth of other pathogens had a significantly higher mortality than patients with negative culture results.
Conclusions: Isolation of microorganisms from the amniotic cavity at birth is associated with an adverse outcome of the preterm infant. In the light of extremely small numbers of positive blood cultures in preterm infants after birth, we consider it reasonable to recommend routine culturing of amniotic cavity tissues/fluid obtained during cesarean section in order to increase the identification rate of pathogens potentially involved in the pathogenesis of perinatal infections.
Copyright © 2003 by Walter de Gruyter GmbH & Co. KG
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- Congress Calendar
Articles in the same Issue
- Mode of conception, placental morphology and perinatal outcome of twin gestations
- The effects of birth weight discordance and prematurity on twin neonatal outcome
- Esophageal atresia and tracheoesophageal fistula: the impact of prenatal suspicion on neonatal outcome in a tertiary care center
- Microbial invasion of the amniotic cavity at birth is associated with adverse short-term outcome of preterm infants
- Is treatment with vaginal pessaries an option in patients with a sonographically detected short cervix?
- The effects of intramuscular administration of corticosteroids on the induction of parturition
- Perinatal significance of diagnosing glucose intolerance during pregnancy with portable glucose meter
- Biovar diversity of Ureaplasma urealyticum in amniotic fluid: distribution, intrauterine inflammatory response and pregnancy outcomes
- Comparative study on the expression of cytokine – receptor genes in normal and preeclamptic human placentas using DNA microarrays
- Chorioangioma – new insights into a well-known problem I. Results of a clinical and morphological study of 136 cases
- Chorioangiomas – new insights into a well-known problem II. An immuno-histochemical investigation of 136 cases
- Impaired CD14-dependent and independent response of polymorphonuclear leukocytes in preterm infants
- The left portal vein is the watershed of the fetal venous system
- Congress Calendar
