Labor induction and meconium: in vitro effects of oxytocin, dinoprostone and misoprostol on rat ileum relative to myometrium
-
B. B. Matonhodze
Abstract
Background. Oxytocin and various prostaglandin preparations are commonly used for pharmacological induction of labor at term. Some prostaglandin preparations appear to be associated with more fetal meconium passage and maternal gastrointestinal side effects than is oxytocin. These adverse effects may be caused by stimulation of bowel smooth muscle in the mother and in the fetus.
Aim. To determine whether the in vitro ileal contractile activities of dinoprostone, misoprostol and oxytocin are in keeping with the variation in rates of meconium staining observed during labor induction with these substances.
Methods. The contractile activity of the drugs was tested on isolated rat uterus and ileum mounted in Tyrode's solution.
Results. Uterine contractions were stimulated by all three drugs, whereas ileal contractions were only stimulated by dinoprostone and misoprostol. Oxytocin had no contractile activity on the ileum. Dinoprostone and misoprostol stimulated significantly (p < 0.05) larger uterine contractions than ileal contractions.
Conclusion. These results provide a pharmacological basis for the increased rate of maternal gastrointestinal complaints and meconium passage with labor induction using dinoprostone and misoprostol compared to oxytocin. Based on the above findings, we postulate that the difference in the rates of meconium passage following misoprostol and dinoprostone administration is caused by pharmacokinetic rather than pharmacodynamic differences between the two drugs.
Copyright © 2002 by Walter de Gruyter GmbH & Co. KG
Articles in the same Issue
- Editorial
- The odds of delivering one, two or three extremely low birth weight (<1000 g) triplet infants: a study of 3288 sets
- Evaluation of a device for objective determination of cervical consistency: A pilot study of devices validity on uterine specimens obtained by total abdominal hysterectomy for benign uterine disease
- Clinical risk factors for deep venous thrombosis in pregnancy and the puerperium
- Waterbirth: water temperature and bathing time mother knows best!
- Anal sphincter injury during vaginal delivery – an argument for cesarean section on request?
- Doppler sonography of uterine arteries at 20–23 weeks: risk assessment of adverse pregnancy outcome by quantification of impedance and notch
- Cadmium concentration in maternal and cord blood and infant birth weight: a study on healthy non-smoking women
- The effects of oral carbohydrate administration on fetal acid base balance
- Labor induction and meconium: in vitro effects of oxytocin, dinoprostone and misoprostol on rat ileum relative to myometrium
- Catch-up growth in fetal malnourished term infants
- Role of surfactant inhibitors in amniotic fluid in respiratory distress syndrome
- Congenital tuberculosis proven by percutaneous liver biopsy: report of a case
- A case of peripartum cardiomyopathy with a transient increase of plasma interleukin-6 concentration occurred following mirror syndrome
- Bilateral cystic adenomatoid lung malformation type III – a rare differential diagnosis of pulmonary hypertension in neonates
- An unexpected case of primary pulmonary hypertension of the neonate (PPHN). Potential role of topical administration of enoxolone
- Urethral catheterization in neonates – how far is too far?
- Congress Calendar
Articles in the same Issue
- Editorial
- The odds of delivering one, two or three extremely low birth weight (<1000 g) triplet infants: a study of 3288 sets
- Evaluation of a device for objective determination of cervical consistency: A pilot study of devices validity on uterine specimens obtained by total abdominal hysterectomy for benign uterine disease
- Clinical risk factors for deep venous thrombosis in pregnancy and the puerperium
- Waterbirth: water temperature and bathing time mother knows best!
- Anal sphincter injury during vaginal delivery – an argument for cesarean section on request?
- Doppler sonography of uterine arteries at 20–23 weeks: risk assessment of adverse pregnancy outcome by quantification of impedance and notch
- Cadmium concentration in maternal and cord blood and infant birth weight: a study on healthy non-smoking women
- The effects of oral carbohydrate administration on fetal acid base balance
- Labor induction and meconium: in vitro effects of oxytocin, dinoprostone and misoprostol on rat ileum relative to myometrium
- Catch-up growth in fetal malnourished term infants
- Role of surfactant inhibitors in amniotic fluid in respiratory distress syndrome
- Congenital tuberculosis proven by percutaneous liver biopsy: report of a case
- A case of peripartum cardiomyopathy with a transient increase of plasma interleukin-6 concentration occurred following mirror syndrome
- Bilateral cystic adenomatoid lung malformation type III – a rare differential diagnosis of pulmonary hypertension in neonates
- An unexpected case of primary pulmonary hypertension of the neonate (PPHN). Potential role of topical administration of enoxolone
- Urethral catheterization in neonates – how far is too far?
- Congress Calendar
