Amniotic fluid matrix metalloproteinase-8 and the development of cerebral palsy
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J. B. Moon
Abstract
Aims: To examine if increased concentrations of matrix metalloproteinase-8 (MMP-8) in amniotic fluid are associated with the development of cerebral palsy at the age of three years.
Methods: The relationship between amniotic fluid concentrations of MMP-8 and the development of cerebral palsy was examined in 116 preterm singleton newborns (gestational age at birth < 35 weeks) born to mothers who underwent amniocentesis and were followed for at least 3 years. Amniotic fluid was cultured for aerobic and anaerobic bacteria and mycoplasmas. MMP-8 concentrations were measured by specific immunoassays. Cerebral palsy was diagnosed by neuro developmental assessment at the age of three years.
Results: Median amniotic fluid concentration of MMP-8 was significantly higher in mothers whose newborns developed cerebral palsy than in mothers whose newborns did not develop cerebral palsy (median 153.9 [range < 0.3–1535.9] ng/ml vs median 6.4 [range < 0.3–3836.8] ng/ml; p < 0.01). Neonates who developed cerebral palsy were delivered at earlier gestational age than those without cerebral palsy. After adjustment for the gestational age at birth and the results of amniotic fluid culture, elevated concentrations of amniotic fluid MMP-8 significantly increased the odds of development of cerebral palsy (odds ratio, 6.0; 95% confidence interval, 1.1–33.0; p < 0.05).
Conclusion: Increased concentrations of amniotic fluid MMP-8 are associated with the subsequent development of cerebral palsy at the age of 3 years.
Copyright © 2002 by Walter de Gruyter GmbH & Co. KG
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Articles in the same Issue
- Taurine and taurine-deficiency in the perinatal period
- The effect of betamethasone administration to pregnant women on maternal serum indicators of infection
- Chorioamnionitis: Elevated interleukin-6 and interleukin-8 concentrations in the lower uterine segment
- Tyrphostins inhibit lipopolysaccharide induced preterm labor in mice
- Amniotic fluid matrix metalloproteinase-8 and the development of cerebral palsy
- Echocardiographic screening for congenital heart disease: a randomized study
- Maternal obesity not maternal glucose values correlates best with high rates of fetal macrosomia in pregnancies complicated by gestational diabetes
- Increased endothelial thrombomodulin (TM) expression in pregnancies complicated by IUGR
- Serum amyloid A protein in the early detection of late-onset bacterial sepsis in preterm infants
- Carbon dioxide levels do not predict duration of home oxygen requirement: a retrospective study
- A congenital anterior diaphragmatic hernia with massive pericardial effusion requiring neither emergency pericardiocentesis nor operation. A case report and review of the literature
- Extravascular collection of fluid around the vertebra resulting from malpositioning of a peripherally inserted central venous catheter in extremely low birth weight infants
- Placental boost to varicella-zoster antibodies in the newborn
- Enhancing decision-making by depressed pregnant patients
- Congress Calendar
- WAPM-Newsletter No 2/2002
